Sustained-release ganciclovir therapy for treatment of cytomegalovirus retinitis. Use of an intravitreal device

Sustained-release ganciclovir therapy for treatment of cytomegalovirus retinitis. Use of an intravitreal device

A surgically implantable device for sustained intravitreal release of ganciclovir has been developed. The device delivers ganciclovir intraocularly over approximately 4 to 5 months. Eight patients with acquired immunodeficiency syndrome (AIDS) and associated cytomegalovirus (CMV) retinitis were recr...

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Bibliographic Details
Published in:Archives of ophthalmology (1960) Vol. 110; no. 2; p. 188
Main Authors: Sanborn, G E, Anand, R, Torti, R E, Nightingale, S D, Cal, S X, Yates, B, Ashton, P, Smith, T
Format: Journal Article
Language:English
Published: United States 01-02-1992
Subjects:
Acquired Immunodeficiency Syndrome - complications
Adult
Cytomegalovirus Infections - drug therapy
Delayed-Action Preparations
Drug Evaluation
Drug Implants
Eye Infections, Viral - drug therapy
Follow-Up Studies
Ganciclovir - pharmacokinetics
Ganciclovir - therapeutic use
Humans
Male
Middle Aged
Retinitis - drug therapy
Retinitis - microbiology
Treatment Outcome
Visual Acuity
Vitreous Body
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Description
Summary:A surgically implantable device for sustained intravitreal release of ganciclovir has been developed. The device delivers ganciclovir intraocularly over approximately 4 to 5 months. Eight patients with acquired immunodeficiency syndrome (AIDS) and associated cytomegalovirus (CMV) retinitis were recruited as part of a phase 1 study. Thirteen eyes with active CMV retinitis underwent surgical implantation of the ganciclovir device. All eyes showed resolution of the CMV retinitis; none showed progression. Visual acuity remained unchanged in three eyes, improved in six eyes, and decreased in four eyes. Surgical complications included mild vitreous hemorrhage, astigmatism, and suprachoroidal placement of the device. Retinal detachment occurred in three eyes as the retinitis resolved. This new intraocular drug delivery system offers many advantages compared with intravenous therapy or repeated intravitreal ganciclovir injections for the management of CMV retinitis in patients with AIDS.
ISSN:0003-9950
DOI:10.1001/archopht.1992.01080140044023