Search Results - "Torrice, Chad D"

SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK) by Asquith, Christopher R. M, Berger, Benedict-Tilman, Wan, Jing, Bennett, James M, Capuzzi, Stephen J, Crona, Daniel J, Drewry, David H, East, Michael P, Elkins, Jonathan M, Fedorov, Oleg, Godoi, Paulo H, Hunter, Debra M, Knapp, Stefan, Müller, Susanne, Torrice, Chad D, Wells, Carrow I, Earp, H. Shelton, Willson, Timothy M, Zuercher, William J

“…We describe SGC-GAK-1 (11), a potent, selective, and cell-active inhibitor of cyclin G-associated kinase (GAK), together with a structurally related negative…”
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Optimization of the 4-anilinoquin(az)oline scaffold as epidermal growth factor receptor (EGFR) inhibitors for chordoma utilizing a toxicology profiling assay platform by Bieberich, Andrew A., Laitinen, Tuomo, Maffuid, Kaitlyn, Fatig, Raymond O., Torrice, Chad D., Morris, David C., Crona, Daniel J., Asquith, Christopher R. M.

“…The 4-anilinoquin(az)oline is a well-known kinase inhibitor scaffold incorporated in clinical inhibitors including gefitinib, erlotinib, afatinib, and…”
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Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition by Johnson, Søren M, Torrice, Chad D, Bell, Jessica F, Monahan, Kimberly B, Jiang, Qi, Wang, Yong, Ramsey, Matthew R, Jin, Jian, Wong, Kwok-Kin, Su, Lishan, Zhou, Daohong, Sharpless, Norman E

“…Total body irradiation (TBI) can induce lethal myelosuppression, due to the sensitivity of proliferating hematopoietic stem/progenitor cells (HSPCs) to…”
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Synthesis and Evaluation of Novel 1,2,6-Thiadiazinone Kinase Inhibitors as Potent Inhibitors of Solid Tumors by Kalogirou, Andreas S., East, Michael P., Laitinen, Tuomo, Torrice, Chad D., Maffuid, Kaitlyn A., Drewry, David H., Koutentis, Panayiotis A., Johnson, Gary L., Crona, Daniel J., Asquith, Christopher R. M.

“…A focused series of substituted 4H-1,2,6-thiadiazin-4-ones was designed and synthesized to probe the anti-cancer properties of this scaffold. Insights from…”
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Influence of Germline Genetics on Tacrolimus Pharmacokinetics and Pharmacodynamics in Allogeneic Hematopoietic Stem Cell Transplant Patients by Zhu, Jing, Patel, Tejendra, Miller, Jordan A, Torrice, Chad D, Aggarwal, Mehak, Sketch, Margaret R, Alexander, Maurice D, Armistead, Paul M, Coghill, James M, Grgic, Tatjana, Jamieson, Katarzyna J, Ptachcinski, Jonathan R, Riches, Marcie L, Serody, Jonathan S, Schmitz, John L, Shaw, J Ryan, Shea, Thomas C, Suzuki, Oscar, Vincent, Benjamin G, Wood, William A, Rao, Kamakshi V, Wiltshire, Tim, Weimer, Eric T, Crona, Daniel J

“…Tacrolimus exhibits high inter-patient pharmacokinetics (PK) variability, as well as a narrow therapeutic index, and therefore requires therapeutic drug…”
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Evaluation of the performance of a prior tacrolimus population pharmacokinetic kidney transplant model among adult allogeneic hematopoietic stem cell transplant patients by Zhu, Jing, Campagne, Olivia, Torrice, Chad D., Flynn, Gabrielle, Miller, Jordan A., Patel, Tejendra, Suzuki, Oscar, Ptachcinski, Jonathan R., Armistead, Paul M., Wiltshire, Tim, Mager, Donald E., Weiner, Daniel L., Crona, Daniel J.

“…Tacrolimus is a calcineurin inhibitor used to prevent acute graft versus host disease in adult patients receiving allogeneic hematopoietic stem cell…”
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Anti-tubercular activity of novel 4-anilinoquinolines and 4-anilinoquinazolines by Asquith, Christopher R.M., Fleck, Neil, Torrice, Chad D., Crona, Daniel J., Grundner, Christoph, Zuercher, William J.

“…We screened a series of 4-anilinoquinolines and 4-anilinoquinazolines and identified novel inhibitors of Mycobacterium tuberculosis (Mtb). The focused…”
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Pharmacokinetics and Pharmacodynamics of Apixaban in Nephrotic Syndrome: Findings From a Phase 1a Trial by Derebail, Vimal K., Zhu, Jing, Crawford, Matthew L., Garnier, Julia R., Martin, Karlyn A., Skinner, Sarah, Patel, Tejendra, Froment, Anne, Sketch, Margaret R., Szeto, Andy H., Patel, Sheel M., Torrice, Chad D., Tiefenbacher, Stefan, Adcock, Dorothy M., Grant, Russell P., Key, Nigel S., Crona, Daniel J.

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Design and evaluation of 1,2,3-dithiazoles and fused 1,2,4-dithiazines as anti-cancer agents by Maffuid, Kaitlyn A., Koyioni, Maria, Torrice, Chad D., Murphy, William A., Mewada, Heemaja K., Koutentis, Panayiotis A., Crona, Daniel J., Asquith, Christopher R.M.

“…[Display omitted] Heteroatom rich 1,2,3-dithiazoles are relatively underexplored in medicinal chemistry. We now report screening data on a series of…”
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Targeting an EGFR Water Network with 4‐Anilinoquin(az)oline Inhibitors for Chordoma by Asquith, Christopher R. M., Maffuid, Kaitlyn A., Laitinen, Tuomo, Torrice, Chad D., Tizzard, Graham J., Crona, Daniel J., Zuercher, William J.

“…Quinoline‐ and quinazoline‐based kinase inhibitors of the epidermal growth factor receptor (EGFR) have been used to target non‐small cell lung cancer (NSCLC)…”
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A New Chemotype of Chemically Tractable Nonsteroidal Estrogens Based on a Thieno[2,3‑d]pyrimidine Core by Sammeta, Vamshikrishna Reddy, Norris, John D., Artham, Sandeep, Torrice, Chad D., Byemerwa, Jovita, Joiner, Carstyn, Fanning, Sean W., McDonnell, Donald P., Willson, Timothy M.

“…Despite continued interest in the development of nonsteroidal estrogens and antiestrogens, there are only a few chemotypes of estrogen receptor ligands. Using…”
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Abstract 1743: Evaluation of the effects of combined chemical inhibition of PARP and BET proteins in preclinical models of urothelial bladder cancer by Maffuid, Kaitlyn A., Torrice, Chad D., Hardy, Brian, Murphy, William A., James, Lindsey I., Kim, William Y., Frye, Stephen V., Pearce, Kenneth J., Crona, Daniel J.

“…Abstract Purpose: Metastatic urothelial bladder cancer (mUC) is incurable, and options are limited after patients fail 1st and 2nd line treatments. Thus, there…”
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Structural Determinants of the Binding and Activation of Estrogen Receptor α by Phenolic Thienopyrimidines by Vamshikrishna Reddy Sammeta, Anderson, Brian M, Norris, John D, Torrice, Chad D, Joiner, Carstyn, Liu, Shubin, Li, Haoxi, Popov, Konstantin I, Fanning, Sean W, McDonnell, Donald P, Willson, Timothy M

“…Synthetic, structural, and computational approaches were used to solve the puzzle as to how a phenolic nonsteroidal estrogen 1 with only a single H‐bond to its…”
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Structural Determinants of the Binding and Activation of Estrogen Receptor α by Phenolic Thieno[2,3‐ d ]pyrimidines by Reddy Sammeta, Vamshikrishna, Anderson, Brian M., Norris, John D., Torrice, Chad D., Joiner, Carstyn, Liu, Shubin, Li, Haoxi, Popov, Konstantin I., Fanning, Sean W., McDonnell, Donald P., Willson, Timothy M.

“…Abstract Synthetic, structural, and computational approaches were used to solve the puzzle as to how a phenolic nonsteroidal estrogen 1 with only a single…”
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Application of a Tacrolimus Population Pharmacokinetic Model to Adult Allogeneic Hematopoietic Stem Cell Transplant Patients by Zhu, Jing, Campagne, Olivia, Torrice, Chad D, Flynn, Gabrielle, Miller, Jordan A, Patel, Tejendra, Suzuki, Oscar, Ptachcinski, Jonathan, Armistead, Paul M., Wiltshire, Tim, Mager, Donald, Weiner, Daniel L, Crona, Daniel J

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