Search Results - "Torres, Marcelo D. T"

Minute-scale detection of SARS-CoV-2 using a low-cost biosensor composed of pencil graphite electrodes by de Lima, Lucas F., Ferreira, André L., Torres, Marcelo D. T., de Araujog, William R., de la Fuente-Nunez, Cesar

“…COVID-19 has led to over 3.47 million deaths worldwide and continues to devastate primarily middle- and low-income countries. High-frequency testing has been…”
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Synthetic angiotensin II peptide derivatives confer protection against cerebral and severe non-cerebral malaria in murine models by Silva, Adriana F., Torres, Marcelo D. T., Silva, Leandro S., Alves, Flavio L., Miranda, Antonio, Oliveira, Vani X., de la Fuente-Nunez, Cesar, Pinheiro, Ana Acacia S.

“…Malaria can have severe long-term effects. Even after treatment with antimalarial drugs eliminates the parasite, survivors of cerebral malaria may suffer from…”
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Structure-function-guided exploration of the antimicrobial peptide polybia-CP identifies activity determinants and generates synthetic therapeutic candidates by Torres, Marcelo D. T., Pedron, Cibele N., Higashikuni, Yasutomi, Kramer, Robin M., Cardoso, Marlon H., Oshiro, Karen G. N., Franco, Octávio L., Silva Junior, Pedro I., Silva, Fernanda D., Oliveira Junior, Vani X., Lu, Timothy K., de la Fuente-Nunez, Cesar

“…Antimicrobial peptides (AMPs) constitute promising alternatives to classical antibiotics for the treatment of drug-resistant infections, which are a rapidly…”
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Natural and redesigned wasp venom peptides with selective antitumoral activity by Torres, Marcelo D T, Andrade, Gislaine P, Sato, Roseli H, Pedron, Cibele N, Manieri, Tania M, Cerchiaro, Giselle, Ribeiro, Anderson O, de la Fuente-Nunez, Cesar, Oliveira, Jr, Vani X

“…About 1 in 8 U.S. women (≈12%) will develop invasive breast cancer over the course of their lifetime. Surgery, chemotherapy, radiotherapy, and hormone…”
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Synthetic Biology and Computer-Based Frameworks for Antimicrobial Peptide Discovery by Torres, Marcelo D. T, Cao, Jicong, Franco, Octavio L, Lu, Timothy K, de la Fuente-Nunez, Cesar

“…Antibiotic resistance is one of the greatest challenges of our time. This global health problem originated from a paucity of truly effective antibiotic classes…”
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Coatable and Resistance-Proof Ionic Liquid for Pathogen Eradication by Torres, Marcelo D. T, Voskian, Sahag, Brown, Paul, Liu, Andong, Lu, Timothy K, Hatton, T. Alan, de la Fuente-Nunez, Cesar

“…Antibiotic-resistant bacteria infect close to 3 million people, and kill 35,000, each year in the United States. Ionic liquid (IL)-based antimicrobial agents…”
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In silico optimization of a guava antimicrobial peptide enables combinatorial exploration for peptide design by Porto, William F., Irazazabal, Luz, Alves, Eliane S. F., Ribeiro, Suzana M., Matos, Carolina O., Pires, Állan S., Fensterseifer, Isabel C. M., Miranda, Vivian J., Haney, Evan F., Humblot, Vincent, Torres, Marcelo D. T., Hancock, Robert E. W., Liao, Luciano M., Ladram, Ali, Lu, Timothy K., de la Fuente-Nunez, Cesar, Franco, Octavio L.

“…Plants are extensively used in traditional medicine, and several plant antimicrobial peptides have been described as potential alternatives to conventional…”
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Synthetic Antibiotic Derived from Sequences Encrypted in a Protein from Human Plasma by Cesaro, Angela, Torres, Marcelo D. T, Gaglione, Rosa, Dell’Olmo, Eliana, Di Girolamo, Rocco, Bosso, Andrea, Pizzo, Elio, Haagsman, Henk P, Veldhuizen, Edwin J. A, de la Fuente-Nunez, Cesar, Arciello, Angela

“…Encrypted peptides have been recently found in the human proteome and represent a potential class of antibiotics. Here we report three peptides derived from…”
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Molecular Dynamics for Antimicrobial Peptide Discovery by Palmer, Nicholas, Maasch, Jacqueline R M A, Torres, Marcelo D T, de la Fuente-Nunez, César

“…Although antimicrobial resistance is an increasingly significant public health concern, there have only been two new classes of antibiotics approved for human…”
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Mining for encrypted peptide antibiotics in the human proteome by Torres, Marcelo D. T., Melo, Marcelo C. R., Flowers, Laurice, Crescenzi, Orlando, Notomista, Eugenio, de la Fuente-Nunez, Cesar

“…The emergence of drug-resistant bacteria calls for the discovery of new antibiotics. Yet, for decades, traditional discovery strategies have not yielded new…”
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Biologically Active Peptides from Venoms: Applications in Antibiotic Resistance, Cancer, and Beyond by Ageitos, Lucía, Torres, Marcelo D T, de la Fuente-Nunez, Cesar

“…Peptides are potential therapeutic alternatives against global diseases, such as antimicrobial-resistant infections and cancer. Venoms are a rich source of…”
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Antimicrobial and Antibiofilm Activities of Helical Antimicrobial Peptide Sequences Incorporating Metal-Binding Motifs by Agbale, Caleb M, Sarfo, Justice K, Galyuon, Isaac K, Juliano, Samuel A, Silva, Gislaine G. O, Buccini, Danieli F, Cardoso, Marlon H, Torres, Marcelo D. T, Angeles-Boza, Alfredo M, de la Fuente-Nunez, Cesar, Franco, Octavio L

“…Antimicrobial peptides (AMPs) represent alternative strategies to combat the global health problem of antibiotic resistance. However, naturally occurring AMPs…”
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Deep-learning-enabled antibiotic discovery through molecular de-extinction by Wan, Fangping, Torres, Marcelo D. T., Peng, Jacqueline, de la Fuente-Nunez, Cesar

“…Molecular de-extinction aims at resurrecting molecules to solve antibiotic resistance and other present-day biological and biomedical problems. Here we show…”
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Antimicrobial Susceptibility Testing of Antimicrobial Peptides to Better Predict Efficacy by Mercer, Derry K, Torres, Marcelo D T, Duay, Searle S, Lovie, Emma, Simpson, Laura, von Köckritz-Blickwede, Maren, de la Fuente-Nunez, Cesar, O'Neil, Deborah A, Angeles-Boza, Alfredo M

“…During the development of antimicrobial peptides (AMP) as potential therapeutics, antimicrobial susceptibility testing (AST) stands as an essential part of the…”
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An N-capping asparagine-lysine-proline (NKP) motif contributes to a hybrid flexible/stable multifunctional peptide scaffold by Cardoso, Marlon H, Chan, Lai Y, Cndido, Elizabete S, Buccini, Danieli F, Rezende, Samilla B, Torres, Marcelo D. T, Oshiro, Karen G. N, Silva, Ítala C, Gonçalves, Sónia, Lu, Timothy K, Santos, Nuno C, de la Fuente-Nunez, Cesar, Craik, David J, Franco, Octávio L

“…Structural diversity drives multiple biological activities and mechanisms of action in linear peptides. Here we describe an unusual N-capping…”
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Computer-Aided Design of Mastoparan-like Peptides Enables the Generation of Nontoxic Variants with Extended Antibacterial Properties by Oshiro, Karen G. N, Cândido, Elizabete S, Chan, Lai Y, Torres, Marcelo D. T, Monges, Bruna E. D, Rodrigues, Silvia G, Porto, William F, Ribeiro, Suzana M, Henriques, Sónia T, Lu, Timothy K, de la Fuente-Nunez, Cesar, Craik, David J, Franco, Octávio L, Cardoso, Marlon H

“…Diverse peptides have been evaluated for their activity against pathogenic microorganisms. Here, five mastoparan variants were designed based on mastoparan-L,…”
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Next-generation precision antimicrobials: towards personalized treatment of infectious diseases by de la Fuente-Nunez, Cesar, Torres, Marcelo DT, Mojica, Francisco JM, Lu, Timothy K

“…Highlights • Precision antimicrobials represent a novel approach for treating infectious diseases. • The role of the microbiota in health and disease is…”
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Short Cationic Peptide Derived from Archaea with Dual Antibacterial Properties and Anti-Infective Potential by Cândido, Elizabete S, Cardoso, Marlon H, Chan, Lai Y, Torres, Marcelo D. T, Oshiro, Karen G. N, Porto, William F, Ribeiro, Suzana M, Haney, Evan F, Hancock, Robert E. W, Lu, Timothy K, de la Fuente-Nunez, Cesar, Craik, David J, Franco, Octávio L

“…Bacterial biofilms and associated infections represent one of the biggest challenges in the clinic, and as an alternative to counter bacterial infections,…”
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Peptide Design Principles for Antimicrobial Applications by Torres, Marcelo D.T., Sothiselvam, Shanmugapriya, Lu, Timothy K., de la Fuente-Nunez, Cesar

“…The increased incidence of bacterial resistance to available antibiotics represents a major global health problem and highlights the need for novel…”
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Antimicrobial Susceptibility Testing of Antimicrobial Peptides Requires New and Standardized Testing Structures by Meurer, Marita, O’Neil, Deborah A, Lovie, Emma, Simpson, Laura, Torres, Marcelo D. T, de la Fuente-Nunez, Cesar, Angeles-Boza, Alfredo M, Kleinsorgen, Christin, Mercer, Derry K, von Köckritz-Blickwede, Maren

“…The need for optimized as well as standardized test systems of novel antimicrobial peptides (AMPs) was discussed by experts in the field at the International…”
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