Search Results - "Torres, Jacob A."

Pharmacological Effects of Panduratin A on Renal Cyst Development in In Vitro and In Vivo Models of Polycystic Kidney Disease by Tonum, Kanlayanee, Srimai, Nipitpon, Chabang, Napason, Fongsupa, Somsak, Tuchinda, Patoomratana, Torres, Jacob A, Weimbs, Thomas, Soodvilai, Sunhapas

“…Renal cyst expansion in polycystic kidney disease (PKD) involves abnormalities in both cyst-lining-cell proliferation and fluid accumulation. Suppression of…”
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Identification of targets of IL-13 and STAT6 signaling in polycystic kidney disease by Olsan, Erin E, West, Jonathan D, Torres, Jacob A, Doerr, Nicholas, Weimbs, Thomas

“…Autosomal dominant polycystic kidney disease (ADPKD) is a life-threatening, highly prevalent monogenic disease caused by mutations in polycystin-1 (PC1) in 85%…”
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β-hydroxybutyrate recapitulates the beneficial effects of ketogenic metabolic therapy in polycystic kidney disease by Torres, Jacob A., Holznecht, Nickolas, Asplund, David A., Kroes, Bradley C., Amarlkhagva, Tselmeg, Haeffner, Matthias M., Sharpe, Elizabeth H., Koestner, Stella, Strubl, Sebastian, Schimmel, Margaret F., Kruger, Samantha, Agrawal, Shagun, Aceves, Brina A., Thangaraju, Muthusamy, Weimbs, Thomas

“…Autosomal-dominant polycystic kidney disease (ADPKD) is a common monogenic disease characterized by the formation of fluid-filled renal cysts, loss of…”
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Ketosis Ameliorates Renal Cyst Growth in Polycystic Kidney Disease by Torres, Jacob A., Kruger, Samantha L., Broderick, Caroline, Amarlkhagva, Tselmeg, Agrawal, Shagun, Dodam, John R., Mrug, Michal, Lyons, Leslie A., Weimbs, Thomas

“…Mild reduction in food intake was recently shown to slow polycystic kidney disease (PKD) progression in mouse models, but whether the effect was due to solely…”
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Trigger Warning: How Modern Diet, Lifestyle, and Environment Pull the Trigger on Autosomal Dominant Polycystic Kidney Disease Progression by Messing, Melina, Torres, Jacob A, Holznecht, Nickolas, Weimbs, Thomas

“…Understanding chronic kidney disease (CKD) through the lens of evolutionary biology highlights the mismatch between our Paleolithic-optimized genes and modern…”
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A combination of β-hydroxybutyrate and citrate ameliorates disease progression in a rat model of polycystic kidney disease by Torres, Jacob A, Holznecht, Nickolas, Asplund, David A, Amarlkhagva, Tselmeg, Kroes, Bradley C, Rebello, Juliette, Agrawal, Shagun, Weimbs, Thomas

“…Our research has shown that interventions producing a state of ketosis are highly effective in rat, mouse, and cat models of polycystic kidney disease (PKD),…”
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Crystal deposition triggers tubule dilation that accelerates cystogenesis in polycystic kidney disease by Torres, Jacob A, Rezaei, Mina, Broderick, Caroline, Lin, Louis, Wang, Xiaofang, Hoppe, Bernd, Cowley, Jr, Benjamin D, Savica, Vincenzo, Torres, Vicente E, Khan, Saeed, Holmes, Ross P, Mrug, Michal, Weimbs, Thomas

“…The rate of disease progression in autosomal-dominant (AD) polycystic kidney disease (PKD) exhibits high intra-familial variability suggesting that…”
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STAT signaling in polycystic kidney disease by Strubl, Sebastian, Torres, Jacob A., Spindt, Alison K., Pellegrini, Hannah, Liebau, Max C., Weimbs, Thomas

“…The most common form of polycystic kidney disease (PKD) in humans is caused by mutations in the PKD1 gene coding for polycystin1 (PC1). Among the many…”
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Ketogenic dietary interventions in autosomal dominant polycystic kidney disease—a retrospective case series study: first insights into feasibility, safety and effects by Strubl, Sebastian, Oehm, Simon, Torres, Jacob A, Grundmann, Franziska, Haratani, Jazmine, Decker, Morgan, Vuong, Sabrina, Kaur Bhandal, Amrit, Methot, Nils, Haynie-Cion, Rhianna, Meyer, Franziska, Siedek, Florian, Korst, Uwe, Müller, Roman-Ulrich, Weimbs, Thomas

“…Abstract Background Our laboratory published the first evidence that nutritional ketosis, induced by a ketogenic diet (KD) or time-restricted diet (TRD),…”
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Macronutrient Composition and Protein Intake of a Plant-Focused, Kidney-Safe Ketogenic Approach for Individuals With Autosomal Dominant Polycystic Kidney Disease: PUB191 by Saville, Jessianna, Paimanta, Clarissa S., Bruen, Diana, Torres, Jacob A., Weimbs, Thomas

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Time-Restricted Feeding Outperforms Periodic Fasting Head-to-Head in Slowing and Reversing Progression of Polycystic Kidney Disease in the Han:SPRD Rat Model: FR-PO295 by Torres, Jacob A., Holznecht, Nickolas J., Asplund, David A., Kroes, Bradley C., Strubl, Sebastian, Schimmel, Margaret, Weimbs, Thomas

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A Combination Therapy with Two Dietary Supplements Acting on Different Mechanisms Ameliorates Disease Progression in a Rat Model of Polycystic Kidney Disease: PO1265 by Torres, Jacob A., Asplund, David A., Kroes, Bradley C., Holznecht, Nickolas J., Amarlkhagva, Tselmeg, Rebello, Juliette R., Weimbs, Thomas

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Uric Acid Crystal Deposition Triggers Tubule Dilation in Normal Kidneys and Cystogenesis in Polycystic Kidney Disease (PKD): FR-PO242 by Strubl, Sebastian, Holznecht, Nickolas J., Torres, Jacob A., Aceves, Brina A., Schimmel, Margaret, Asplund, David A., Kroes, Bradley C., Arjune, Sita, Mueller, Roman-Ulrich, Harris, Peter C., Weimbs, Thomas

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Ren.Nu, a Dietary Program for Individuals with Autosomal-Dominant Polycystic Kidney Disease Implementing a Sustainable, Plant-Focused, Kidney-Safe, Ketogenic Approach with Avoidance of Renal Stressors by Bruen, Diana M., Kingaard, Jacob J., Munits, Meg, Paimanta, Clarissa S., Torres, Jacob A., Saville, Jessianna, Weimbs, Thomas

“…Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited cause of renal failure and has limited pharmacological treatment options…”
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