Unraveling the multifaceted nature of the nuclear function of mTOR

Positioned at the axis between the cell and its environment, mTOR directs a wide range of cellular activity in response to nutrients, growth factors, and stress. Our understanding of the role of mTOR is evolving beyond the spatial confines of the cytosol, and its role in the nucleus becoming ever mo...

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Bibliographic Details
Published in:	Biochimica et biophysica acta. Molecular cell research Vol. 1868; no. 2; p. 118907
Main Authors:	Torres, Alek S, Holz, Marina K
Format:	Journal Article
Language:	English
Published:	Netherlands 01-02-2021
Subjects:	Cell Nucleus - metabolism Humans TOR Serine-Threonine Kinases - metabolism mTOR Nucleus Signaling Nuclear receptor Rapamycin Kinase
Online Access:	Get more information
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Summary:	Positioned at the axis between the cell and its environment, mTOR directs a wide range of cellular activity in response to nutrients, growth factors, and stress. Our understanding of the role of mTOR is evolving beyond the spatial confines of the cytosol, and its role in the nucleus becoming ever more apparent. In this review, we will address various studies that explore the role of nuclear mTOR (nmTOR) in specific cellular programs and how these pathways influence one another. To understand the emerging roles of nuclear mTOR, we discuss data and propose plausible mechanisms to offer novel ideas, hypotheses, and future research directions.
ISSN:	1879-2596
DOI:	10.1016/j.bbamcr.2020.118907