Search Results - "Torrero, Marina"

Immunologic characterization of 3 murine regimens of allergen-specific immunotherapy by Fox, Ellen Mueller, PhD, Torrero, Marina N., PhD, Evans, Holly, BS, Mitre, Edward, MD

“…Background Allergen-specific immunotherapy (ASIT) is used to treat the symptoms of immediate type I hypersensitivity. The mechanisms driving establishment of…”
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Helminth protection against autoimmune diabetes in nonobese diabetic mice is independent of a type 2 immune shift and requires TGF-β by Hübner, Marc P, Shi, Yinghui, Torrero, Marina N, Mueller, Ellen, Larson, David, Soloviova, Kateryna, Gondorf, Fabian, Hoerauf, Achim, Killoran, Kristin E, Stocker, J Thomas, Davies, Stephen J, Tarbell, Kristin V, Mitre, Edward

“…Leading hypotheses to explain helminth-mediated protection against autoimmunity postulate that type 2 or regulatory immune responses induced by helminth…”
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Induction of Type 2 Responses by Schistosome Worms during Prepatent Infection by de Oliveira Fraga, Lucia Alves, Torrero, Marina N., Tocheva, Anna S., Mitre, Edward, Davies, Stephen J.

“…During natural schistosome infection, the induction of T helper type 2 (Th2) responses has been ascribed to parasite eggs, because exposure of the host to this…”
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Chronic helminth infection does not exacerbate Mycobacterium tuberculosis infection by Hübner, Marc P, Killoran, Kristin E, Rajnik, Michael, Wilson, Samuel, Yim, Kevin C, Torrero, Marina N, Morris, Christopher P, Nikonenko, Boris, Blanco, Jorge C G, Hemming, Val G, Mitre, Edward

“…Chronic helminth infections induce a Th2 immune shift and establish an immunoregulatory milieu. As both of these responses can suppress Th1 immunity, which is…”
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Basophils amplify type 2 immune responses, but do not serve a protective role, during chronic infection of mice with the filarial nematode Litomosoides sigmodontis by Torrero, Marina N, Hübner, Marc P, Larson, David, Karasuyama, Hajime, Mitre, Edward

“…Chronic helminth infections induce a type 2 immune response characterized by eosinophilia, high levels of IgE, and increased T cell production of type 2…”
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Chronic helminth infection reduces basophil responsiveness in an IL-10-dependent manner by Larson, David, Hübner, Marc P, Torrero, Marina N, Morris, Christopher P, Brankin, Amy, Swierczewski, Brett E, Davies, Stephen J, Vonakis, Becky M, Mitre, Edward

“…Basophils play a key role in the development and effector phases of type 2 immune responses in both allergic diseases and helminth infections. This study shows…”
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Tissue specific diversification, virulence and immune response to Mycobacterium bovis BCG in a patient with an IFN-γ R1 deficiency by Korol, Cecilia B., Shallom, Shamira J., Arora, Kriti, Boshoff, Helena I., Freeman, Alexandra F., King, Alejandra, Agrawal, Sonia, Daugherty, Sean C., Jancel, Timothy, Kabat, Juraj, Ganesan, Sundar, Torrero, Marina N., Sampaio, Elizabeth P., Barry, Clifton, Holland, Steve M, Tettelin, Hervé, Rosenzweig, Sergio D, Zelazny, Adrian M.

“…We characterized Mycobacterium bovis BCG isolates found in lung and brain samples from a previously vaccinated patient with IFNγR1 deficiency. The isolates…”
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Basophils help establish protective immunity induced by irradiated larval vaccination for filariasis by Torrero, Marina N, Morris, C. Paul, Mitre, Blima K, Hübner, Marc P, Fox, Ellen M, Karasuyama, Hajime, Mitre, Edward

“…Highlights • Basophils help establish protective immunity induced by irradiated larval vaccination for filariasis. • Basophil depletion attenuates protective…”
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Anti-FcεR1 antibody injections activate basophils and mast cells and delay Type 1 diabetes onset in NOD mice by Hübner, Marc P, Larson, David, Torrero, Marina N, Mueller, Ellen, Shi, Yinghui, Killoran, Kristin E, Mitre, Edward

“…Abstract Mounting evidence suggests that helminth infections protect against autoimmune diseases. As helminths cause chronic IgE-mediated activation of…”
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Type 2 immune-inducing helminth vaccination maintains protective efficacy in the setting of repeated parasite exposures by Hübner, Marc P, Torrero, Marina N, Mitre, Edward

“…Abstract Animal studies have demonstrated that helminth vaccines which induce type 2 immune responses can be protective. To date, however, such vaccines have…”
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Axenic Caenorhabditis elegans antigen protects against development of type-1 diabetes in NOD mice by Jackson-Thompson, Belinda M., Torrero, Marina, Mitre, Blima K., Long, James, Packiam, Mathanraj, Mitre, Edward

“…Studies in humans and animals have demonstrated that infection with helminths (parasitic worms) is protective against a range of hyperinflammatory diseases. A…”
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Litomosoides sigmodontis: A simple method to infect mice with L3 larvae obtained from the pleural space of recently infected jirds ( Meriones unguiculatus) by Hübner, Marc P., Torrero, Marina N., McCall, John W., Mitre, Edward

“…Litomosoides sigmodontis is a filarial nematode that is used as a mouse model for human filarial infections. The life cycle of L. sigmodontis comprises rodents…”
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Regression of High-Grade Malignancy in Mice by Bleomycin and Interleukin-12 Electrochemogenetherapy by Torrero, Marina N, Henk, William G, Li, Shulin

“…Purpose: Bleomycin electrochemotherapy has been successfully used in preclinical studies and clinical trials for treating squamous cell carcinoma (SCC) and…”
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Vaccination with intestinal tract antigens does not induce protective immunity in a permissive model of filariasis by Morris, C. Paul, Torrero, Marina N., Larson, David, Evans, Holly, Shi, Yinghui, Cox, Rachel T., Mitre, Edward

“…•L. sigmodontis intestinal antigens (GutAg)exhibit qualities of hidden antigens.•Infected mice develop allergy associated immune responses to GutAg.•Vaccinated…”
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Stat1 deficiency in the host enhances interleukin-12-mediated tumor regression by Torrero, Marina N, Xia, Xueqing, Henk, Williams, Yu, Shry, Li, Shulin

“…Signal transducer and activator of transcription 1 (Stat1) is considered a key transcription factor that inhibits tumorigenesis, and Stat1 activation in the…”
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Biological implications of Mycobacterium leprae gene expression during infection by Williams, Diana L, Torrero, Marina, Wheeler, Paul R, Truman, Richard W, Yoder, Mark, Morrison, Norman, Bishai, William R, Gillis, Thomas P

“…The genome of Mycobacterium leprae, the etiologic agent of leprosy, has been sequenced and annotated revealing a genome in apparent disarray and in stark…”
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Treatment of SCCVII tumors with systemic chemotherapy and Interleukin-12 gene therapy combination by Torrero, Marina, Li, Shulin

“…Cyclophosphamide and Interleukin-12 (IL-12) have been successfully used in clinical trials for treating malignancies. In this study, we explore the…”
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Administration of anti-FcER1 antibody injections daily for 10 consecutive days delays type 1 diabetes onset in NOD mice (119.11) by Torrero, Marina, Hübner, Marc, Shi, Yinghui, Mitre, Edward

“…Helminth infections protect against autoimmune diseases. In this study, we investigated whether mimicking the immune response induced by helminths could…”
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Intratumoral bleomycin and IL-12 electrochemogenetherapy for treating head and neck tumors in dogs by Cutrera, Jeffry, Torrero, Marina, Shiomitsu, Keijiro, Mauldin, Neal, Li, Shulin

“…Bleomycin and Interleukin 12 have been used clinically to treat tumors; however, the co-administration of Bleomycin and Interleukin 12 followed by…”
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Correction: Basophils Amplify Type 2 Immune Responses, but Do Not Serve a Protective Role, during Chronic Infection of Mice with the Filarial Nematode Litomosoides sigmodontis by Torrero, Marina N., Hübner, Marc P., Larson, David, Karasuyama, Hajime, Mitre, Edward

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