Search Results - "Torrence, P F"

Intrinsic molecular activities of the interferon-induced 2-5A-dependent RNase by BEIHUA DONG, LULU XU, AIMIN ZHOU, HASSEL, B. A, LEE, X, TORRENCE, P. F, SILVERMAN, R. H

“…2-5A-dependent RNase (RNase L), a unique endoribonuclease that requires 5'-phosphorylated 2',5'-linked oligoadenylates (2-5A), functions in the molecular…”
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Targeting RNA for degradation with a (2'-5')oligoadenylate-antisense chimera by TORRENCE, P. F, MAITRA, R. K, LESIAK, K, SHAHRZAD KHAMNEI, AIMIN ZHOU, SILVERMAN, R. H

“…Antisense oligonucleotides hold considerable promise both as research tools for inhibiting gene expression and as agents for the treatment of a myriad of human…”
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Blockage of NF-κB Signaling by Selective Ablation of an mRNA Target by 2-5A Antisense Chimeras by Maran, Avudaiappan, Maitra, Ratan K., Kumar, Aseem, Dong, Beihua, Xiao, Wei, Li, Guiying, Bryan R. G. Williams, Torrence, Paul F., Silverman, Robert H.

“…Activation of 2-5A-dependent ribonuclease by 5′-phosphorylated, 2′,5′-linked oligoadenylates, known as 2-5A, is one pathway of interferon action. Unaided…”
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2-5A-DNA conjugate inhibition of respiratory syncytial virus replication: effects of oligonucleotide structure modifications and RNA target site selection by Barnard, D.L, Sidwell, R.W, Xiao, W, Player, M.R, Adah, S.A, Torrence, P.F

“…To define more fully the conditions for 2-5A-antisense inhibition of respiratory syncytial virus (RSV), relationships between 2-5A antisense oligonucleotide…”
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The 2-5A system: modulation of viral and cellular processes through acceleration of RNA degradation by Player, M R, Torrence, P F

“…The 2-5A system is an RNA degradation pathway that can be induced by the interferons (IFNs). Treatment of cells with IFN activates genes encoding several…”
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Synthesis and Properties of Second-Generation 2-5A-Antisense Chimeras with Enhanced Resistance to Exonucleases by Li, Guiying, Xiao, Wei, Torrence, Paul F

“…In order to stabilize 2-5A-antisense chimeras to exonucleases, we have synthesized chimeric oligonucleotides in which the last phosphodiester bond at the…”
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Accelerating RNA decay through intervention of RNase L: alternative synthesis of composite 2',5'-oligoadenylate-antisense by Torrence, P F, Wang, Z

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Comparative Efficacy of Antiherpes Drugs against Different Strains of Herpes Simplex Virus by De Clercq, E., Descamps, J., Verhelst, G., Walker, R. T., Jones, A. S., Torrence, P. F., Shugar, D.

“…A large variety of antiherpes compounds was compared for their inhibitory activity against laboratory strains and clinical isolates of herpes simplex virus…”
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Discrimination between ribonuclease H- and ribonuclease L-mediated RNA degradation by 2′- O-methylated 2-5A-antisense oligonucleotides by Cramer, Hagen, Player, Mark R., Torrence, Paul F.

“…2′,5′-Oligoadenylate (2-5A) antisense chimeric oligonucleotides were synthesized containing varying 2′- O-methyl-ribonucleotide substitution patterns in the…”
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Targeting RNase L to Human Immunodeficiency Virus RNA with 2-5A-Antisense by Player, Maitra, RK, Silverman, RH, Torrence, PF

“…In an attempt to develop a lead for the application of 2–5A-antisense to the targeted destruction of human immunodeficiency virus (HIV) RNA, specific target…”
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2',5'-Oligoadenylate:antisense chimeras. Synthesis and properties by Lesiak, Krystyna, Khamnei, Shahrzad, Torrence, Paul F

“…We have synthesized a novel bioconjugate which joins an antisense oligonucleotide to a unique and potent inhibitor of translation,pn5'A2'(p5'A2')mp5'A(2-5A)…”
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Phosphorothioate oligodeoxyribonucleotides inhibit ribonuclease L thereby disabling a mechanism of interferon action by Player, Mark R., Torrence, Paul F.

“…Phosphorothioate oligodeoxyribonucleotides were found to be inhibitors of the 2-5A-dependent RNase L. Inhibitory potency depended upon the chain length of the…”
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Convergent synthesis of ribonuclease L-active 2′,5′-oligoadenylate-peptide nucleic acids by Wang, Zhengfu, Chen, Ling, Bayly, Suzanne F., Torrence, Paul F.

“…2-5A was conjugated to N-(2-aminoethyl)-glycyl PNA by periodate oxidization, followed by coupling with amino-derivatized PNA and final cyanoborohydride…”
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Neighboring Group Catalysis in the Design of Nucleotide Prodrugs by Khamnei, Shahrzad, Torrence, Paul F

“…An approach is described for potential application to the delivery of polar nucleosides and nucleotides across lipophilic membranes, namely, nucleotide…”
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Nuclease-Resistant Composite 2‘,5‘-Oligoadenylate−3‘,5‘-Oligonucleotides for the Targeted Destruction of RNA:  2−5A-Iso-antisense by Xiao, Wei, Li, Guiying, Player, Mark R, Maitra, Ratan K, Waller, Cornelius F, Silverman, Robert H, Torrence, Paul F

“…A new modification of 2−5A-antisense, 2−5A-iso-antisense, has been developed based on a reversal of the direction of the polarity of the antisense domain of a…”
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2-Methyladenosine-substituted 2', 5'-oligoadenylates : Conformations, 2-5A binding and catalytic activities with human ribonuclease L by KITADE, Y, WAKANA, M, TSUBOI, T, YATOME, C, BAYLY, S. F, PLAYER, M. R, TORRENCE, P. F

“…2-Methyladenosine-substituted analogues of 2-5A, p5'A2'p5'A2'p5'(me2A), p5'(me2A)2'p5'A2'p5'A, and p5'(me2A) 2'p5'(me2A)2'pS'(me2A), were prepared via a…”
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The Endangered Species Act by Torrence, Paul F.

“…Abstract only…”
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A study of the interferon antiviral mechanism: apoptosis activation by the 2-5A system by Castelli, J C, Hassel, B A, Wood, K A, Li, X L, Amemiya, K, Dalakas, M C, Torrence, P F, Youle, R J

“…The 2-5A system contributes to the antiviral effect of interferons through the synthesis of 2-5A and its activation of the ribonuclease, RNase L. RNase L…”
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Correlation of Selective Modifications to a 2‘,5‘-Oligoadenylate−3‘,5‘-Deoxyribonucleotide Antisense Chimera with Affinity for the Target Nucleic Acid and with Ability To Activate RNase L by Xiao, Wei, Li, Guiying, Maitra, Ratan K, Maran, Avudaiappan, Silverman, Robert H, Torrence, Paul F

“…The use of an antisense oligonucleotide to address a specific targeted RNA sequence and subsequent localized activation of the 2-5A-dependent RNase (RNase L)…”
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Purine 8-bromination modulates the ribonuclease L binding and activation abilities of 2',5'-oligoadenylates. Possible influence of glycosyl torsion angle by Lesiak, K., Torrence, P.F.

“…Analogs of the 2',5'-linked adenylate trimer diphosphate (pp5'A2'p5'A2'p5'A or 2-5A) containing 8-bromoadenosine in the first, second, third, first and third,…”
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