Endurance Training and Chronic Intermittent Hypobaric-Hypoxia Modulate Liver Mitochondrial Bioenergetics. Role Against Salicylate-Induced Mitochondrial Dysfunction
PURPOSE: To analyze the effects of ET and CIHH on LM bioenergetics under basal conditions and with salicylate. METHODS: Twenty-eight young-adult male rats were divided into normoxic-sedentary (NS), normoxic-exercised (NE), hypoxic-sedentary (HS) and hypoxic-exercised (HE). ET consisted of 1h/d of tr...
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| Published in: | Medicine and science in sports and exercise Vol. 44; no. 5S; p. 357 |
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| Main Authors: | , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
01-05-2012
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| Online Access: | Get full text |
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| Summary: | PURPOSE: To analyze the effects of ET and CIHH on LM bioenergetics under basal conditions and with salicylate. METHODS: Twenty-eight young-adult male rats were divided into normoxic-sedentary (NS), normoxic-exercised (NE), hypoxic-sedentary (HS) and hypoxic-exercised (HE). ET consisted of 1h/d of treadmill running and CIHH of 5wks, 5h/d simulated atmospheric pressure of 49.3kPa. RESULTS: ET and CIHH decreased basal state 3 (NS-249 vs. NE-161, HS-168, HE-170 natomsO/min/mg,p<0.05) and state 4 (NS-74 vs. NE-46, HS-33, HE-45 natomsO/min/mg,p<0.05). No alterations were observed in membrane potential endpoints evaluated under basal conditions. ET and CIHH decreased caspase 8 activity (NS-1150 vs. NE-864, HS-545, HE-537 pNa/[upsilon]g,p<0.05) whereas no effect was observed on caspase 3. The levels of SIRT3 increased with ET and CIHH (NS-100 vs. NE-150, HS-128, HE-151%,p<0.05) and Cyp D decreased with CIHH per se (NS-100 vs. HS-83%,p<0.05). No differences were observed in HSP70 and OXPHOS subunits. |
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| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 content type line 23 ObjectType-Feature-2 |
| ISSN: | 0195-9131 |