Quality control of 99Mo/99Tcm generators: results of a survey of the Radiopharmacy Working Group of the Italian Association of Nuclear Medicine (AIMN)

A multicentre survey of the quality control of 99Tcm generators has been completed: 245 generators from seven different commercial sources were tested over a period of 2 years. The results indicate that the mean pH of the eluates was 5.8 +/- 0.6; the aluminium contents were typically < 10 ppm; th...

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Bibliographic Details
Published in:	Nuclear medicine communications Vol. 20; no. 11; p. 1077
Main Authors:	Marengo, M, Aprile, C, Bagnara, C, Bolzati, C, Bonada, C, Candini, G, Casati, R, Civollani, S, Colombo, F R, Compagnone, G, Del Dottore, F, Di Guglielmo, E, Ferretti, P P, Lazzari, S, Minoia, C, Pancaldi, D, Ronchi, A, Sanità di Toppi, G, Saponaro, R, Torregiani, T, Uccelli, L, Vecchi, F, Piffanelli, A
Format:	Journal Article
Language:	English
Published:	England 01-11-1999
Subjects:	Hydrogen-Ion Concentration Indicators and Reagents Italy Molybdenum - chemistry Molybdenum - isolation & purification Quality Control Radioisotopes Radionuclide Generators - standards Radiopharmaceuticals - chemistry Radiopharmaceuticals - isolation & purification Radiopharmaceuticals - standards Spectrophotometry, Atomic Technetium - chemistry Technetium - isolation & purification Trace Elements - analysis Italy
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Summary:	A multicentre survey of the quality control of 99Tcm generators has been completed: 245 generators from seven different commercial sources were tested over a period of 2 years. The results indicate that the mean pH of the eluates was 5.8 +/- 0.6; the aluminium contents were typically < 10 ppm; the radiochemical purity was 99.8 +/- 0.4% and the median 99Mo content was 3.8 x 10(-4) percent. The elution profiles gave a volume of 1.9 ml to obtain 50% of the total eluted activity and of 4.9 ml to obtain 95%. Other radionuclide impurities and heavy metal breakthrough were evaluated by graphite furnace absorption spectrometry and inductively coupled plasma mass spectrometry. National guidelines for the standardization of radiopharmacy procedures are currently being compiled.
ISSN:	0143-3636
DOI:	10.1097/00006231-199911000-00014