Search Results - "Torrance, James W"

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    Evolution of binding sites for zinc and calcium ions playing structural roles by Torrance, James W., MacArthur, Malcolm W., Thornton, Janet M.

    “…The geometry of metal coordination by proteins is well understood, but the evolution of metal binding sites has been less studied. Here we present a study on a…”
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    Journal Article
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    Using a Library of Structural Templates to Recognise Catalytic Sites and Explore their Evolution in Homologous Families by Torrance, James W., Bartlett, Gail J., Porter, Craig T., Thornton, Janet M.

    Published in Journal of molecular biology (01-04-2005)
    “…Catalytic site structure is normally highly conserved between distantly related enzymes. As a consequence, templates representing catalytic sites have the…”
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    MACiE (Mechanism, Annotation and Classification in Enzymes): novel tools for searching catalytic mechanisms by Holliday, Gemma L, Almonacid, Daniel E, Bartlett, Gail J, O'Boyle, Noel M, Torrance, James W, Murray-Rust, Peter, Mitchell, John B O, Thornton, Janet M

    Published in Nucleic acids research (01-01-2007)
    “…MACiE (Mechanism, Annotation and Classification in Enzymes) is a database of enzyme reaction mechanisms, and is publicly available as a web-based data…”
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    Journal Article
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    MACiE (Mechanism, Annotation and Classification in Enzymes): novel tools for searching catalytic mechanisms by Holliday, Gemma L, Almonacid, Daniel E, Bartlett, Gail J, O'Boyle, Noel M, Torrance, James W, Murray-Rust, Peter, Mitchell, John B.O, Thornton, Janet M

    Published in Nucleic acids research (01-01-2007)
    “…MACiE (Mechanism, Annotation and Classification in Enzymes) is a database of enzyme reaction mechanisms, and is publicly available as a web-based data…”
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    Journal Article
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    The Geometry of Interactions between Catalytic Residues and their Substrates by Torrance, James W., Holliday, Gemma L., Mitchell, John B.O., Thornton, Janet M.

    Published in Journal of molecular biology (15-06-2007)
    “…The process of deducing the catalytic mechanism of an enzyme from its structure is highly complex and requires extensive experimental work to validate a…”
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