Search Results - "Torpier, Gérard"

The Farnesoid X Receptor Modulates Adiposity and Peripheral Insulin Sensitivity in Mice by Cariou, Bertrand, van Harmelen, Kirsten, Duran-Sandoval, Daniel, van Dijk, Theo H., Grefhorst, Aldo, Abdelkarim, Mouaadh, Caron, Sandrine, Torpier, Gérard, Fruchart, Jean-Charles, Gonzalez, Frank J, Kuipers, Folkert, Staels, Bart

“…The farnesoid X receptor (FXR) is a bile acid (BA)-activated nuclear receptor that plays a major role in the regulation of BA and lipid metabolism. Recently,…”
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PPARγ Activation Primes Human Monocytes into Alternative M2 Macrophages with Anti-inflammatory Properties by Bouhlel, M. Amine, Derudas, Bruno, Rigamonti, Elena, Dièvart, Rébecca, Brozek, John, Haulon, Stéphan, Zawadzki, Christophe, Jude, Brigitte, Torpier, Gérard, Marx, Nikolaus, Staels, Bart, Chinetti-Gbaguidi, Giulia

“…Th1 cytokines promote monocyte differentiation into proatherogenic M1 macrophages, while Th2 cytokines lead to an “alternative” anti-inflammatory M2 macrophage…”
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Peroxisome Proliferator–Activated Receptor α Improves Pancreatic Adaptation to Insulin Resistance in Obese Mice and Reduces Lipotoxicity in Human Islets by LALLOYER, Fanny, VANDEWALLE, Brigitte, FIEVET, Catherine, STAELS, Bart, PERCEVAULT, Frédéric, TORPIER, Gérard, KERR-CONTE, Julie, OOSTERVEER, Maaike, PAUMELLE, Réjane, FRUCHART, Jean-Charles, KUIPERS, Folkert, PATTOU, Francois

“…Peroxisome Proliferator–Activated Receptor α Improves Pancreatic Adaptation to Insulin Resistance in Obese Mice and Reduces Lipotoxicity in Human Islets Fanny…”
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The RXR Agonist Bexarotene Improves Cholesterol Homeostasis and Inhibits Atherosclerosis Progression in a Mouse Model of Mixed Dyslipidemia by Lalloyer, Fanny, Fiévet, Catherine, Lestavel, Sophie, Torpier, Gérard, van der Veen, Jelske, Touche, Véronique, Bultel, Stéphanie, Yous, Saïd, Kuipers, Folkert, Paumelle, Réjane, Fruchart, Jean-Charles, Staels, Bart, Tailleux, Anne

“…OBJECTIVE—The activity of the antitumoral agent bexarotene (Targretin, Bexarotene) depends on its binding to the nuclear retinoid-X receptor (RXR) and…”
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S 26948: a new specific peroxisome proliferator activated receptor gamma modulator with potent antidiabetes and antiatherogenic effects by Carmona, Maria Carmen, Louche, Katie, Lefebvre, Bruno, Pilon, Antoine, Hennuyer, Nathalie, Audinot-Bouchez, Véronique, Fievet, Catherine, Torpier, Gérard, Formstecher, Pierre, Renard, Pierre, Lefebvre, Philippe, Dacquet, Catherine, Staels, Bart, Casteilla, Louis, Pénicaud, Luc

“…Rosiglitazone displays powerful antidiabetes benefits but is associated with increased body weight and adipogenesis. Keeping in mind the concept of selective…”
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TReP-132 Is a Novel Progesterone Receptor Coactivator Required for the Inhibition of Breast Cancer Cell Growth and Enhancement of Differentiation by Progesterone by Gizard, Florence, Robillard, Romain, Gross, Barbara, Barbier, Olivier, Révillion, Françoise, Peyrat, Jean-Philippe, Torpier, Gérard, Hum, Dean W., Staels, Bart

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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PPARα, but not PPARγ, Activators Decrease Macrophage-Laden Atherosclerotic Lesions in a Nondiabetic Mouse Model of Mixed Dyslipidemia by Hennuyer, Nathalie, Tailleux, Anne, Torpier, Gérard, Mezdour, Hafid, Fruchart, Jean-Charles, Staels, Bart, Fiévet, Catherine

“…OBJECTIVE—Peroxisome proliferator-activated receptor (PPAR) α and γ are nuclear receptors that may modulate atherogenesis, not only by correcting metabolic…”
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A New Function for the LDL Receptor: Transcytosis of LDL across the Blood-Brain Barrier by Dehouck, Bénédicte, Fenart, Laurence, Dehouck, Marie-Pierre, Pierce, Annick, Torpier, Gérard, Cecchelli, Roméo

“…Lipoprotein transport across the blood-brain barrier (BBB) is of critical importance for the delivery of essential lipids to the brain cells. The occurrence of…”
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Reduction of Atherosclerosis in Apolipoprotein E Knockout Mice by Activation of the Retinoid X Receptor by Claudel, Thierry, Leibowitz, Mark D., Fiévet, Catherine, Tailleux, Anne, Wagner, Brandee, Repa, Joyce J., Torpier, Gérard, Lobaccaro, Jean-Marc, Paterniti, James R., Mangelsdorf, David J., Heyman, Richard A., Auwerx, Johan

“…A common feature of many metabolic pathways is their control by retinoid X receptor (RXR) heterodimers. Dysregulation of such metabolic pathways can lead to…”
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Physiological pathway for low-density lipoproteins across the blood-brain barrier: transcytosis through brain capillary endothelial cells in vitro by Candela, Pietra, Gosselet, Fabien, Miller, Florence, Buee-Scherrer, Valerie, Torpier, Gérard, Cecchelli, Roméo, Fenart, Laurence

“…Although an immense knowledge has accumulated concerning regulation of cholesterol homeostasis in the body, this does not include the brain, where details are…”
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The PPARα Activator Fenofibrate Slows Down the Progression of the Left Ventricular Dysfunction in Porcine Tachycardia-Induced Cardiomyopathy by Brigadeau, François, Gelé, Patrick, Wibaux, Maud, Marquié, Christelle, Martin-Nizard, Françoise, Torpier, Gérard, Fruchart, Jean-Charles, Staels, Bart, Duriez, Patrick, Lacroix, Dominique

“…It has been reported that high intramyocardial peroxisome proliferator-activated receptor α (PPARα) stimulation or overexpression altered cardiac contractile…”
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Dyslipidemia shifts the tissue factor/tissue factor pathway inhibitor balance toward increased thrombogenicity in atherosclerotic plaques: evidence for a corrective effect of statins by Zawadzki, Christophe, Susen, Sophie, Richard, Florence, Haulon, Stéphan, Corseaux, Delphine, Jeanpierre, Emmanuelle, Vincentelli, André, Lucas, Christian, Torpier, Gérard, Martin, Annie, Van Belle, Eric, Staels, Bart, Jude, Brigitte

“…Tissue factor (TF) is a key mediator of atherosclerotic plaque thrombogenicity and may be regulated by plaque TF pathway inhibitor (TFPI). High atherogenic…”
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Protective effect of glial cells against lipopolysaccharide-mediated blood-brain barrier injury by Descamps, Laurence, Coisne, Caroline, Dehouck, Bénédicte, Cecchelli, Romeo, Torpier, Gérard

“…Numerous infections of the central nervous system are characterized by altered blood‐brain barrier (BBB) functions leading to brain damage. To study the…”
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S 26948 by Carmona, Maria Carmen, Louche, Katie, Lefebvre, Bruno, Pilon, Antoine, Hennuyer, Nathalie, Audinot-Bouchez, Véronique, Fievet, Catherine, Torpier, Gérard, Formstecher, Pierre, Renard, Pierre, Lefebvre, Philippe, Dacquet, Catherine, Staels, Bart, Casteilla, Louis, Pénicaud, Luc

“…S 26948 a New Specific Peroxisome Proliferator–Activated Receptor γ Modulator With Potent Antidiabetes and Antiatherogenic Effects Maria Carmen Carmona 1 ,…”
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Dyslipidemia shifts the tissue factor/tissue factor pathway inhibitor balance toward increased thrombogenicity in atherosclerotic plaques by Zawadzki, Christophe, Susen, Sophie, Richard, Florence, Haulon, Stéphan, Corseaux, Delphine, Jeanpierre, Emmanuelle, Vincentelli, André, Lucas, Christian, Torpier, Gérard, Martin, Annie, Van Belle, Eric, Staels, Bart, Jude, Brigitte

“…Abstract Background Tissue factor (TF) is a key mediator of atherosclerotic plaque thrombogenicity and may be regulated by plaque TF pathway inhibitor (TFPI)…”
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Endothelin-1 as a mediator of endothelial cell-pericyte interactions in bovine brain capillaries by Dehouck, M P, Vigne, P, Torpier, G, Breittmayer, J P, Cecchelli, R, Frelin, C

“…Endothelial cells and pericytes are closely associated in brain capillaries. Together with astrocytic foot processes, they form the blood-brain barrier…”
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Hypoxia increases the susceptibility to oxidant stress and the permeability of the blood-brain barrier endothelial cell monolayer by Plateel, M, Dehouck, M P, Torpier, G, Cecchelli, R, Teissier, E

“…Using a cell culture model of the blood-brain barrier (BBB), we investigated the brain capillary endothelial cell (EC) response to hypoxia. The activities of…”
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Toxoplasma gondii: characterization and localization of antigens secreted from tachyzoites by Charif, H, Darcy, F, Torpier, G, Cesbron-Delauw, M F, Capron, A

“…Since we had previously demonstrated the protective role played by Toxoplasma excreted-secreted antigens, the aim of the present work was to produce monoclonal…”
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Characterization of a new mouse model for human apolipoprotein A-I/C-III/A-IV deficiency by Mezdour, Hafid, Larigauderie, Guilhem, Castro, Graciela, Torpier, Gerard, Fruchart, Jamila, Nowak, Maxime, Fruchart, Jean-Charles, Rouis, Mustapha, Maeda, Nobuyo

“…Human data raised the possibility that coronary heart disease is associated with mutations in the apolipoprotein gene cluster APOA1/C3/A4 that result in…”
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Reduction of atherosclerosis by the peroxisome proliferator-activated receptor alpha agonist fenofibrate in mice by Duez, Hélène, Chao, Yu-Sheng, Hernandez, Melba, Torpier, Gérard, Poulain, Philippe, Mundt, Steven, Mallat, Ziad, Teissier, Elisabeth, Burton, Charlotte A, Tedgui, Alain, Fruchart, Jean-Charles, Fiévet, Catherine, Wright, Sam D, Staels, Bart

“…Several clinical and angiographic intervention trials have shown that fibrate treatment leads to a reduction of the coronary events associated to…”
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