Search Results - "Torok, Natalie J."

Dysregulation of redox pathways in liver fibrosis by Torok, Natalie J

“…Reactive oxygen species are implicated in physiological signaling and cell fate decisions. In chronic liver diseases persistent and increased production of…”
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Primary sclerosing cholangitis and the path to translation by Vancza, Lorand, Torok, Natalie J

“…Primary sclerosing cholangitis (PSC) is a rare liver disease characterized by inflammation and fibrosis of the bile ducts. Despite advancements in diagnosis,…”
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Metabolic dysfunction−associated liver disease and diabetes: Matrix remodeling, fibrosis, and therapeutic implications by Fan, Weiguo, Bradford, Toby M., Török, Natalie J.

“…Metabolic dysfunction−associated liver disease (MASLD) and steatohepatitis (MASH) are becoming the most common causes of chronic liver disease in the United…”
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Non-alcoholic Fatty Liver Disease and Liver Fibrosis during Aging by Li, Yuan, Adeniji, Nia T, Fan, Weiguo, Kunimoto, Koshi, Török, Natalie J

“…Non-alcoholic fatty liver disease (NAFLD) and its progressive form non-alcoholic steatohepatitis (NASH) have emerged as the leading causes of chronic liver…”
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Pre‐clinical evidence of a dual NADPH oxidase 1/4 inhibitor (setanaxib) in liver, kidney and lung fibrosis by Thannickal, Victor J., Jandeleit‐Dahm, Karin, Szyndralewiez, Cédric, Török, Natalie J.

“…Fibrosis describes a dysregulated tissue remodelling response to persistent cellular injury and is the final pathological consequence of many chronic diseases…”
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Strategies and endpoints of antifibrotic drug trials: Summary and recommendations from the AASLD Emerging Trends Conference, Chicago, June 2014 by Torok, Natalie J., Dranoff, Jonathan A., Schuppan, Detlef, Friedman, Scott L.

“…There is an urgent need to develop antifibrotic therapies for chronic liver disease, and clarify which endpoints in antifibrotic trials will be acceptable to…”
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The NOX1 isoform of NADPH oxidase is involved in dysfunction of liver sinusoids in nonalcoholic fatty liver disease by Matsumoto, Misaki, Zhang, Jia, Zhang, Xueqing, Liu, Junjie, Jiang, Joy X., Yamaguchi, Kanji, Taruno, Akiyuki, Katsuyama, Masato, Iwata, Kazumi, Ibi, Masakazu, Cui, Wenhao, Matsuno, Kuniharu, Marunaka, Yoshinori, Itoh, Yoshito, Torok, Natalie J., Yabe-Nishimura, Chihiro

“…The increased production of reactive oxygen species (ROS) has been postulated to play a key role in the progression of nonalcoholic fatty liver disease…”
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Apoptotic body engulfment by hepatic stellate cells promotes their survival by the JAK/STAT and Akt/NF-κB-dependent pathways by Jiang, Joy X, Mikami, Kenichiro, Venugopal, Senthil, Li, Yong, Török, Natalie J

“…Background/Aims We have previously shown that phagocytosis of apoptotic bodies (AB) by hepatic stellate cells (HSC) is profibrogenic. As HSC survival is…”
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Neutrophil–Hepatic Stellate Cell Interactions Promote Fibrosis in Experimental Steatohepatitis by Zhou, Zhou, Xu, Ming-Jiang, Cai, Yan, Wang, Wei, Jiang, Joy X, Varga, Zoltan V, Feng, Dechun, Pacher, Pal, Kunos, George, Torok, Natalie J, Gao, Bin

“…Background & Aims Hepatic infiltration of neutrophils is a hallmark of steatohepatitis; however, the role of neutrophils in the progression of steatohepatitis…”
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Shc inhibitor idebenone ameliorates liver injury and fibrosis in dietary NASH in mice by Jiang, Joy X., Tomilov, Alexey, Montgomery, Claire, Hui, Chun Kui, Török, Natalie J., Cortopassi, Gino

“…Shc expression rises in human nonalcoholic steatohepatitis (NASH) livers, and Shc‐deficient mice are protected from NASH—thus Shc inhibition could be a novel…”
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Recent advances in the pathogenesis and diagnosis of liver fibrosis by Török, Natalie J.

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Editorial: Noninvasive Fibrosis Biomarkers in Patients With NASH With Diabetes by Fan, Weiguo, Torok, Natalie J.

“…This is an editorial about non‐invasive fibrosis markers in patients with NASH and type 2 diabetes mellitus…”
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Update on Alcoholic Hepatitis by Torok, Natalie J

“…Alcoholic liver disease is one of the most prevalent liver diseases worldwide, and a major cause of morbidity and mortality. Alcoholic hepatitis is a severe…”
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Patterns and co-occurrence of risk factors for hepatocellular carcinoma in four Asian American communities: a cross-sectional study by Stewart, Susan L, Dang, Julie Ht, Török, Natalie J, Chen, Jr, Moon S

“…To investigate risk factor patterns and the simultaneous occurrence of multiple risk factors in the viral, metabolic and lifestyle domains among Asian…”
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Soluble Epoxide Hydrolase Hepatic Deficiency Ameliorates Alcohol-Associated Liver Disease by Mello, Aline, Hsu, Ming-Fo, Koike, Shinichiro, Chu, Bryan, Cheng, Jeff, Yang, Jun, Morisseau, Christophe, Torok, Natalie J., Hammock, Bruce D., Haj, Fawaz G.

“…Alcohol-associated liver disease (ALD) is a significant cause of liver-related morbidity and mortality worldwide and with limited therapies. Soluble epoxide…”
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Adenosine induces loss of actin stress fibers and inhibits contraction in hepatic stellate cells via Rho inhibition by Sohail, Muhammad A., Hashmi, Ardeshir Z., Hakim, Wyel, Watanabe, Azuma, Zipprich, Alexander, Groszmann, Roberto J., Dranoff, Jonathan A., Torok, Natalie J., Mehal, Wajahat Z.

“…The Rho/ROCK pathway is activated in differentiated hepatic stellate cells (HSCs) and is necessary for assembly of actin stress fibers, contractility, and…”
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P300, A New Player in Mechanosensitivity and Activation of Cancer-Associated Fibroblasts by Torok, Natalie J.

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Vascular adhesion protein 1 in nonalcoholic steatohepatitis: A novel biomarker? by Torok, Natalie J.

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AGER1 downregulation associates with fibrosis in nonalcoholic steatohepatitis and type 2 diabetes by Dehnad, Ali, Fan, Weiguo, Jiang, Joy X, Fish, Sarah R, Li, Yuan, Das, Suvarthi, Mozes, Gergely, Wong, Kimberly A, Olson, Kristin A, Charville, Gregory W, Ali, Mohammed, Török, Natalie J

“…Type 2 diabetes is clinically associated with progressive necroinflammation and fibrosis in nonalcoholic steatohepatitis (NASH). Advanced glycation…”
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Macrophage Nourishment in Nonalcoholic Steatohepatitis: A Novel Role for Ketone Bodies by Torok, Natalie J., Corey, Kathleen E., Malhi, Harmeet

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