Search Results - "Toro, Andras"

Furanophane Transannular Diels−Alder Approach to (+)-Chatancin:  An Asymmetric Total Synthesis of (+)-Anhydrochatancin by Toró, András, Deslongchamps, Pierre

“…(+)-Anhydrochatancin was synthesized while attempting an enantioselective total synthesis of (+)-chatancin. The presented route constitutes the furanophane…”
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Pyranophane Transannular Diels−Alder Approach to (+)-Chatancin:  A Biomimetic Asymmetric Total Synthesis by Soucy, Pierre, L'Heureux, Alexandre, Toró, András, Deslongchamps, Pierre

“…An asymmetric total synthesis of (+)-chatancin was achieved via a transannular Diels−Alder (TADA) reaction of an in situ generated macrocyclic pyranophane…”
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Structure and mechanism of action of the hydroxy–aryl–aldehyde class of IRE1 endoribonuclease inhibitors by Sanches, Mario, Duffy, Nicole M., Talukdar, Manisha, Thevakumaran, Nero, Chiovitti, David, Canny, Marella D., Lee, Kenneth, Kurinov, Igor, Uehling, David, Al-awar, Rima, Poda, Gennadiy, Prakesch, Michael, Wilson, Brian, Tam, Victor, Schweitzer, Colleen, Toro, Andras, Lucas, Julie L., Vuga, Danka, Lehmann, Lynn, Durocher, Daniel, Zeng, Qingping, Patterson, John B., Sicheri, Frank

“…Endoplasmic reticulum (ER) stress activates the unfolded protein response and its dysfunction is linked to multiple diseases. The stress transducer IRE1α is a…”
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Niobium Oxide Photocatalytically Oxidizes Ammonia in Water at Ambient Conditions by Elias, Welman, Clark, Chelsea, Heck, Kimberly, Arredondo, Jacob, Wang, Bo, Toro, Andras, Kürti, László, Wong, Michael

“…Ammonia contamination in water is a significant environmental issue since it is toxic and leads to eutrophication. Photocatalysis has been investigated as a…”
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Structure‐activity optimization of 4H‐pyridopyrimidines: a class of selective bacterial protein synthesis inhibitors by Bullard, James M, Guiles, Joseph W., Toro, Andras, Ochsner, Urs

“…Introduction Bacterial protein synthesis is the target for numerous natural and synthetic antibacterial agents. Previous screening of a focused chemical…”
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2,3,4,5-Tetrahydro-1H-pyrido[2,3- b and e][1,4]diazepines as inhibitors of the bacterial enoyl ACP reductase, FabI by Ramnauth, Jailall, Surman, Mathew D., Sampson, Peter B., Forrest, Bryan, Wilson, Jeff, Freeman, Emily, Manning, David D., Martin, Fernando, Toro, Andras, Domagala, Megan, Awrey, Donald E., Bardouniotis, Elias, Kaplan, Nachum, Berman, Judd, Pauls, Henry W.

“…Using a structure guided approach, naphthyridionone FabI inhibitors were expanded to novel 2,3,4,5-tetrahydro-1H-pyrido[2,3- b and e][1,4]diazepines (e.g.,…”
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Identification of a Nonpeptidic and Conformationally Restricted Bradykinin B1 Receptor Antagonist with Anti-Inflammatory Activity by D'Amico, Derin C, Aya, Toshi, Human, Jason, Fotsch, Christopher, Chen, Jian Jeffrey, Biswas, Kaustav, Riahi, Bobby, Norman, Mark H, Willoughby, Christopher A, Hungate, Randall, Reider, Paul J, Biddlecome, Gloria, Lester-Zeiner, Dianna, Van Staden, Carlo, Johnson, Eileen, Kamassah, Augustus, Arik, Leyla, Wang, Judy, Viswanadhan, Vellarkad N, Groneberg, Robert D, Zhan, James, Suzuki, Hideo, Toro, Andras, Mareska, David A, Clarke, David E, Harvey, Darren M, Burgess, Laurence E, Laird, Ellen R, Askew, Benny, Ng, Gordon

“…We report the discovery of chroman 28, a potent and selective antagonist of human, nonhuman primate, rat, and rabbit bradykinin B1 receptors (0.4−17 nM). At 90…”
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Potent Nonpeptide Antagonists of the Bradykinin B1 Receptor:  Structure−Activity Relationship Studies with Novel Diaminochroman Carboxamides by Biswas, Kaustav, Li, Aiwen, Chen, Jian Jeffrey, D'Amico, Derin C, Fotsch, Christopher, Han, Nianhe, Human, Jason, Liu, Qingyian, Norman, Mark H, Riahi, Bobby, Yuan, Chester, Suzuki, Hideo, Mareska, David A, Zhan, James, Clarke, David E, Toro, Andras, Groneberg, Robert D, Burgess, Laurence E, Lester-Zeiner, Dianna, Biddlecome, Gloria, Manning, Barton H, Arik, Leyla, Dong, Hong, Huang, Ming, Kamassah, Augustus, Loeloff, Richard, Sun, Hong, Hsieh, Feng-Yin, Kumar, Gondi, Ng, Gordon Y, Hungate, Randall W, Askew, Benny C, Johnson, Eileen

“…The bradykinin B1 receptor is induced following tissue injury and/or inflammation. Antagonists of this receptor have been studied as promising candidates for…”
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Development of 4H-pyridopyrimidines: a class of selective bacterial protein synthesis inhibitors by Guiles, Joseph W, Toro, Andras, Ochsner, Urs A, Bullard, James M

“…Background We have identified a series of compounds that inhibit protein synthesis in bacteria. Initial IC 50 's in aminoacylation/translation (A/T) assays…”
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Use of the transannular Diels-Alder (TADA) reaction to probe biological receptors: Rational design and synthesis of tricyclic TADA adducts capable of rigidly holding by Chantigny, Yves A, Dory, Yves L, Toro, Andras, Deslongchamps, Pierre

“…Transannular Diels-Alder (TADA) adducts constitute a collection of rigid structures, whose conformational diversity is rich. It is possible to design such…”
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Mechanism of the Gibbs Reaction. 3. Indophenol Formation via Radical Electrophilic Aromatic Substitution (SREAr) on Phenols by Pallagi, Istvan, Toro, Andras, Farkas, Odon

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The transannular Diels–Alder strategy: applications to total synthesis by Marsault, Eric, Toró, András, Nowak, Pawel, Deslongchamps, Pierre

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Transannular Diels−Alder Entry into Stemodanes:  First Asymmetric Total Synthesis of (+)-Maritimol by Toró, András, Nowak, Pawel, Deslongchamps, Pierre

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Transannular Diels−Alder Studies on the Asymmetric Total Synthesis of Chatancin:  The Pyranophane Approach by Toró, András, L'Heureu, Alexandre, Deslongchamps, Pierre

“…A pathway is proposed for the biosynthesis of (+)-chatancin and (+)-sarcophytin linking these tetracycles to cembranoids by a pyranophane transannular…”
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Mechanism of the Gibbs Reaction. Part 4. Indophenol Formation via N-Chlorobenzoquinone Imine Radical Anions. The Aza-SRN2 Chain Reaction Mechanism. Chain Initiation with 1,4-Benzoquinones and Cyanide Ion by Pallagi, István, Toró, András, Horváth, Gyula

“…The mechanism of the Gibbs reaction, a colorimetric phenol assay that applies N-chlorobenzoquinone imines 1 in an aqueous basic medium, was investigated. It is…”
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Mechanism of the Gibbs Reaction. Part 4. 1 Indophenol Formation via N -Chlorobenzoquinone Imine Radical Anions. The Aza-S RN 2 Chain Reaction Mechanism. Chain Initiation with 1,4-Benzoquinones and Cyanide Ion by Pallagi, István, Toró, András, Horváth, Gyula

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Transannular Diels-Alder model studies on the total synthesis of chatancin. The furanophane approach. Part 2 [1]: Macrocyclization and Diels-Alder reaction by Toró, András, Wang, Yuan, Drouin, Marc, Deslongchamps, Pierre

“…Title investigation of three generations of model substrates targeting chatancin is presented. An unfunctionalized furan affords a reversible transannular…”
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Transannular Diels-Alder model studies on the total synthesis of chatancin. The furanophane approach. Part 1: Assembly of the acyclic substrates by Toró, András, Wang, Yuan, Deslongchamps, Pierre

“…Synthesis of three generations of model substrates with advancing similarity to chatancin are presented. In the first two generations, an Ireland-Claisen based…”
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Mechanism of the Gibbs Reaction. Part 4.(1) Indophenol Formation via N-Chlorobenzoquinone Imine Radical Anions. The Aza-S(RN)2 Chain Reaction Mechanism. Chain Initiation with 1,4-Benzoquinones and Cyanide Ion by Pallagi, István, Toró, András, Horváth, Gyula

“…The mechanism of the Gibbs reaction, a colorimetric phenol assay that applies N-chlorobenzoquinone imines 1 in an aqueous basic medium, was investigated. It is…”
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Synthesis of chiral trans-syn-cis and trans-anti-trans [6.6.6] tricycles by transannular Diels-Alder reaction by Lavoie, Rico, Toró, András, Deslongchamps, Pierre

“…Stereocontrolled asymmetric synthesis and transannular Diels-Alder (TADA) reaction of a 14-membered trans-cis-cis (TCC) macrocyclic trienone with an activated…”
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