Lung disease and vitamin D levels in cystic fibrosis infants and preschoolers

Introduction Vitamin D acts on the immune system and lung response. Patients with cystic fibrosis (CF) may be deficient in this vitamin. The aims of the study were to evaluate vitamin D levels and severity of lung disease in infants and preschoolers diagnosed with CF, and to compare them to a group...

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Bibliographic Details
Published in:	Pediatric pulmonology Vol. 54; no. 5; pp. 563 - 574
Main Authors:	Oliveira, Marina S., Matsunaga, Natasha Y., Rodrigues, Marina L. E., Morcillo, André M., de Oliveira Ribeiro, Maria A. G., Ribeiro, Antônio F., C. P. Servidoni, Maria, Nogueira, Roberto José N., Pereira, Monica Corso, Ribeiro, José Dirceu, Toro, Adyléia Aparecida D. C.
Format:	Journal Article
Language:	English
Published:	United States Wiley Subscription Services, Inc 01-05-2019
Subjects:	Biomarkers Child, Preschool Cystic fibrosis Cystic Fibrosis - diagnostic imaging Cystic Fibrosis - epidemiology Cystic Fibrosis - metabolism Exocrine Pancreatic Insufficiency - epidemiology Exocrine Pancreatic Insufficiency - metabolism Female Humans Infant infants and preschoolers Lung - diagnostic imaging Lung - physiopathology lung disease Lung diseases Male neonatal screening Seasons Sunlight Tomography, X-Ray Computed Vitamin D Vitamin D - analogs & derivatives Vitamin D - metabolism Vitamin D Deficiency - epidemiology Vitamin D Deficiency - metabolism lung disease infants and preschoolers neonatal screening cystic fibrosis vitamin D
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Summary:	Introduction Vitamin D acts on the immune system and lung response. Patients with cystic fibrosis (CF) may be deficient in this vitamin. The aims of the study were to evaluate vitamin D levels and severity of lung disease in infants and preschoolers diagnosed with CF, and to compare them to a group of children without pancreatic insufficiency (PI). Methods Patients with CF up to 4 years old were included, and compared to an age‐matched group of children without diagnosis of CF. CF group had medical records and High Resolution Thorax Computed Tomography (HRCCT) evaluated in order to verify the severity of lung disease. Information on demographic data, sun exposure habits, supplemental vitamin D therapy, and on the season at the time of vitamin D sampling were collected for both groups. Results This study included 45 patients in the CF group and 102 in the non‐CF group, with no differences in age (P = 0.327) between them. There was no association between vitamin D levels and markers of lung disease in the CF group. The non‐CF group had lower daily sun exposure (P = 0.034), and lower supplementation than the CF group (P < 0.001). Supplementation and seasonality were the determinant variables for vitamin D levels, which were lower for non‐supplemented children and for assessments during fall/winter. Conclusion There was no association between lung disease severity and vitamin D levels in CF group. Supplementation and seasonality were associated to higher vitamin levels.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Undefined-1 ObjectType-Feature-3 content type line 23
ISSN:	8755-6863 1099-0496
DOI:	10.1002/ppul.24260