Search Results - "Tornqvist, Margareta"

Alkylcobyrinate from sucralose and mechanistic aspects of its Co-C bond cleavage by Motwani, Hitesh V., Shimakoshi, Hisashi, Golding, Bernard T., Törnqvist, Margareta, Hisaeda, Yoshio

“…Reaction of heptamethyl cob(I)yrinate with 1',6'-dichloro-1',6'-dideoxy-beta-D-fructofuranosyl-4-chloro-4-deoxy-alpha-D-galactopyranoside (sucralose) gave an…”
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Hemoglobin adducts of acrylamide in human blood – What has been done and what is next? by Pedersen, Marie, Vryonidis, Efstathios, Joensen, Andrea, Törnqvist, Margareta

“…Acrylamide forms in many commonly consumed foods. In animals, acrylamide causes tumors, neurotoxicity, developmental and reproductive effects. Acrylamide…”
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Pathways to Identify Electrophiles In Vivo Using Hemoglobin Adducts: Hydroxypropanoic Acid Valine Adduct and Its Possible Precursors by Vryonidis, Efstathios, Karlsson, Isabella, Aasa, Jenny, Carlsson, Henrik, Motwani, Hitesh V., Pedersen, Marie, Eriksson, Johan, Törnqvist, Margareta Å.

“…Analytical methods and tools for the characterization of the human exposome by untargeted mass spectrometry approaches are advancing rapidly. Adductomics…”
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Evaluation of molecularly imprinted solid-phase extraction for a 1,2:3,4-diepoxybutane adduct to valine by Möller, Kristina, Davies, Ronnie, Fred, Charlotta, Törnqvist, Margareta, Nilsson, Ulrika

“…A molecularly imprinted polymer, MIP, was prepared and evaluated as SPE sorbent for a cyclicized adduct formed to N-terminal valine (Pyr-Val) in hemoglobin…”
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Mass Spectrometry-Based Strategies for Assessing Human Exposure Using Hemoglobin Adductomics by Rajczewski, Andrew T., Ndreu, Lorena, Vryonidis, Efstathios, Hurben, Alexander K., Jamshidi, Sara, Griffin, Timothy J., Törnqvist, Margareta Å., Tretyakova, Natalia Y., Karlsson, Isabella

“…Hemoglobin (Hb) adducts are widely used in human biomonitoring due to the high abundance of hemoglobin in human blood, its reactivity toward electrophiles, and…”
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Strategy for identifying unknown hemoglobin adducts using adductome LC-MS/MS data: Identification of adducts corresponding to acrylic acid, glyoxal, methylglyoxal, and 1-octen-3-one by Carlsson, Henrik, Törnqvist, Margareta

“…Electrophilic compounds have the ability to form adducts with nucleophilic sites in proteins and DNA in tissues, and thereby constitute risks for toxic…”
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An Adductomic Approach to Identify Electrophiles In Vivo by Carlsson, Henrik, Törnqvist, Margareta

“…Human beings are exposed to many reactive electrophiles, both formed endogenously and from exogenous exposures. Such compounds could react with cellular…”
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Novel 4‑Hydroxybenzyl Adducts in Human Hemoglobin: Structures and Mechanisms of Formation by Rajczewski, Andrew T, Ndreu, Lorena, Pujari, Suresh S, Griffin, Timothy J, Törnqvist, Margareta Å, Karlsson, Isabella, Tretyakova, Natalia Y

“…Humans are exposed to large numbers of electrophiles from their diet, the environment, and endogenous physiological processes. Adducts formed at the N-terminal…”
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LC–MS/MS Screening Strategy for Unknown Adducts to N‑Terminal Valine in Hemoglobin Applied to Smokers and Nonsmokers by Carlsson, Henrik, von Stedingk, Hans, Nilsson, Ulrika, Törnqvist, Margareta

“…Electrophilically reactive compounds have the ability to form adducts with nucleophilic sites in DNA and proteins, constituting a risk for toxic effects. Mass…”
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Dietary intake of acrylamide in the Norwegian EuroMix biomonitoring study: Comparing probabilistic dietary estimates with haemoglobin adduct measurements by Vryonidis, Efstathios, Törnqvist, Margareta, Myhre, Oddvar, Dirven, Hubert, Husøy, Trine

“…Acrylamide is a probable human carcinogen with widespread exposure via food. The present study compared acrylamide intake measurements obtained from…”
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Cancer risk estimation of glycidol based on rodent carcinogenicity studies, a multiplicative risk model and in vivo dosimetry by Aasa, Jenny, Granath, Fredrik, Törnqvist, Margareta

“…Here we evaluate a multiplicative (relative) risk model for improved cancer risk estimation of genotoxic compounds. According to this model, cancer risk is…”
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Measurement of micronuclei and internal dose in mice demonstrates that 3-monochloropropane-1,2-diol (3-MCPD) has no genotoxic potency in vivo by Aasa, Jenny, Törnqvist, Margareta, Abramsson-Zetterberg, Lilianne

“…In this study 3-monochloropropane-1,2-diol (3-MCPD), a compound that appears as contaminant in refined cooking oils, has been studied with regard to…”
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Characterizing Adduct Formation of Electrophilic Skin Allergens with Human Serum Albumin and Hemoglobin by Ndreu, Lorena, Erber, Luke N, Törnqvist, Margareta, Tretyakova, Natalia Y, Karlsson, Isabella

“…Skin (contact) allergy, the most predominant form of immunotoxicity in humans, is caused by small electrophilic compounds (haptens) that modify endogenous…”
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The genotoxic potency of glycidol established from micronucleus frequency and hemoglobin adduct levels in mice by Aasa, Jenny, Abramsson-Zetterberg, Lilianne, Carlsson, Henrik, Törnqvist, Margareta

“…Glycidol is a genotoxic animal carcinogen that has raised concern due to its presence in food, as glycidyl fatty acid esters. Here we investigated the…”
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Adductomic Screening of Hemoglobin Adducts and Monitoring of Micronuclei in School-Age Children by Carlsson, Henrik, Aasa, Jenny, Kotova, Natalia, Vare, Daniel, Sousa, Pedro F. M, Rydberg, Per, Abramsson-Zetterberg, Lilianne, Törnqvist, Margareta

“…Electrophilic compounds/metabolites present in humans, originating from endogenous processes or exogenous exposure, pose a risk to health effects through their…”
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A new modified Edman procedure for analysis of N-terminal valine adducts in hemoglobin by LC–MS/MS by von Stedingk, Hans, Rydberg, Per, Törnqvist, Margareta

“…A rapid and sensitive method using liquid chromatography–tandem mass spectrometry (LC–MS/MS) for simultaneous determination of adducts from acrylamide,…”
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A Review of Dietary Intake of Acrylamide in Humans by Timmermann, Clara, Mølck, Signe, Kadawathagedara, Manik, Bjerregaard, Anne, Törnqvist, Margareta, Brantsæter, Anne, Pedersen, Marie

“…The dietary intake of acrylamide (AA) is a health concern, and food is being monitored worldwide, but the extent of AA exposure from the diet is uncertain. The…”
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Characterization of a Hemoglobin Adduct from Ethyl Vinyl Ketone Detected in Human Blood Samples by Carlsson, Henrik, Motwani, Hitesh V, Osterman Golkar, Siv, Törnqvist, Margareta

“…Electrophiles have the ability to form adducts to nucleophilic sites in proteins and DNA. Internal exposure to such compounds thus constitutes a risk for toxic…”
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Evaluation of retinol binding protein 4 and carbamoylated haemoglobin as potential renal toxicity biomarkers in adult mice treated with Lu-177-octreotate by Dalmo, Johanna, Westberg, Emelie, Barregård, Lars, Svedbok, Lisa, Johansson, Martin, Törnqvist, Margareta, Forssell-Aronsson, Eva

“…Background: The kidneys are regarded as one of the main dose-limiting organs in the treatment of neuroendocrine tumours with Lu-177-[DOTA(0),…”
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Discovery of Novel N‑(4-Hydroxybenzyl)valine Hemoglobin Adducts in Human Blood by Degner, Amanda, Carlsson, Henrik, Karlsson, Isabella, Eriksson, Johan, Pujari, Suresh S, Tretyakova, Natalia Y, Törnqvist, Margareta

“…Humans are exposed to a wide range of electrophilic compounds present in our diet and environment or formed endogenously as part of normal physiological…”
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