Search Results - "Tornin, Juan"

Evaluation of the effects of cold atmospheric plasma and plasma-treated liquids in cancer cell cultures by Tornin, Juan, Labay, Cédric, Tampieri, Francesco, Ginebra, Maria-Pau, Canal, Cristina

“…Cold atmospheric plasma (CAP) is a potential anticancer therapy. CAP has cytotoxic effects when applied either directly to cancer cell cultures or indirectly…”
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Pyruvate Plays a Main Role in the Antitumoral Selectivity of Cold Atmospheric Plasma in Osteosarcoma by Tornin, Juan, Mateu-Sanz, Miguel, Rodríguez, Aida, Labay, Cédric, Rodríguez, Rene, Canal, Cristina

“…Osteosarcoma (OS) is the most common primary bone tumor but current therapies still have poor prognosis. Cold Atmospheric Plasma (CAP) and Plasma activated…”
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Osteosarcoma: Cells-of-Origin, Cancer Stem Cells, and Targeted Therapies by Rodriguez, Rene, Garcia-Castro, Javier, González, M. Victoria, Rodrigo, Juan P., Martinez-Campos, Enrique, Hamilton, Ashley, Martinez-Cruzado, Lucia, Tornin, Juan, Abarrategi, Ander, Baldini, Nicola

“…Osteosarcoma (OS) is the most common type of primary solid tumor that develops in bone. Although standard chemotherapy has significantly improved long-term…”
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FUS-CHOP Promotes Invasion in Myxoid Liposarcoma through a SRC/FAK/RHO/ROCK-Dependent Pathway by Tornin, Juan, Hermida-Prado, Francisco, Padda, Ranjit Singh, Gonzalez, M. Victoria, Alvarez-Fernandez, Carlos, Rey, Veronica, Martinez-Cruzado, Lucia, Estupiñan, Oscar, Menendez, Sofia T., Fernandez-Nevado, Lucia, Astudillo, Aurora, Rodrigo, Juan P., Lucien, Fabrice, Kim, Yohan, Leong, Hon S., Garcia-Pedrero, Juana Maria, Rodriguez, Rene

“…Deregulated SRC/FAK signaling leads to enhanced migration and invasion in many types of tumors. In myxoid and round cell liposarcoma (MRCLS), an adipocytic…”
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Expression of FUS‐CHOP fusion protein in immortalized/transformed human mesenchymal stem cells drives mixoid liposarcoma formation by Rodriguez, Rene, Tornin, Juan, Suarez, Carlos, Astudillo, Aurora, Rubio, Ruth, Yauk, Carole, Williams, Andrew, Rosu‐Myles, Michael, Funes, Juan M., Boshoff, Chris, Menendez, Pablo

“…Increasing evidence supports that mesenchymal stromal/stem cells (MSCs) may represent the target cell for sarcoma development. Although different sarcomas have…”
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Trabectedin and Campthotecin Synergistically Eliminate Cancer Stem Cells in Cell-of-Origin Sarcoma Models by Martinez-Cruzado, Lucia, Tornin, Juan, Rodriguez, Aida, Santos, Laura, Allonca, Eva, Fernandez-Garcia, Maria Teresa, Astudillo, Aurora, Garcia-Pedrero, Juana Maria, Rodriguez, Rene

“…Abstract Trabectedin has been approved for second-line treatment of soft tissue sarcomas. However, its efficacy to target sarcoma initiating cells has not been…”
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Inhibition of SP1 by the mithramycin analog EC-8042 efficiently targets tumor initiating cells in sarcoma by Tornin, Juan, Martinez-Cruzado, Lucia, Santos, Laura, Rodriguez, Aida, Núñez, Luz-Elena, Oro, Patricia, Hermosilla, Maria Ana, Allonca, Eva, Fernández-García, Maria Teresa, Astudillo, Aurora, Suarez, Carlos, Morís, Francisco, Rodriguez, Rene

“…Tumor initiating cells (TICs), responsible for tumor initiation, and cancer stem cells (CSCs), responsible for tumor expansion and propagation, are often…”
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A personalized medicine approach identifies enasidenib as an efficient treatment for IDH2 mutant chondrosarcoma by Rey, Verónica, Tornín, Juan, Alba-Linares, Juan Jose, Robledo, Cristina, Murillo, Dzohara, Rodríguez, Aida, Gallego, Borja, Huergo, Carmen, Viera, Cristina, Braña, Alejandro, Astudillo, Aurora, Heymann, Dominique, Szuhai, Karoly, Bovée, Judith V.M.G., Fernández, Agustín F., Fraga, Mario F., Alonso, Javier, Rodríguez, René

“…Sarcomas represent an extensive group of malignant diseases affecting mesodermal tissues. Among sarcomas, the clinical management of chondrosarcomas remains a…”
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Bone Environment is Essential for Osteosarcoma Development from Transformed Mesenchymal Stem Cells by Rubio, Ruth, Abarrategi, Ander, Garcia‐Castro, Javier, Martinez‐Cruzado, Lucia, Suarez, Carlos, Tornin, Juan, Santos, Laura, Astudillo, Aurora, Colmenero, Isabel, Mulero, Francisca, Rosu‐Myles, Michael, Menendez, Pablo, Rodriguez, Rene

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The SRC Inhibitor Dasatinib Induces Stem Cell-Like Properties in Head and Neck Cancer Cells that are Effectively Counteracted by the Mithralog EC-8042 by Hermida-Prado, Francisco, Villaronga, M Ángeles, Granda-Díaz, Rocío, Del-Río-Ibisate, Nagore, Santos, Laura, Hermosilla, Maria Ana, Oro, Patricia, Allonca, Eva, Agorreta, Jackeline, Garmendia, Irati, Tornín, Juan, Perez-Escuredo, Jhudit, Fuente, Rocío, Montuenga, Luis M, Morís, Francisco, Rodrigo, Juan P, Rodríguez, René, García-Pedrero, Juana M

“…The frequent dysregulation of SRC family kinases (SFK) in multiple cancers prompted various inhibitors to be actively tested in preclinical and clinical…”
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The multikinase inhibitor EC‐70124 synergistically increased the antitumor activity of doxorubicin in sarcomas by Estupiñan, Oscar, Santos, Laura, Rodriguez, Aida, Fernandez‐Nevado, Lucia, Costales, Paula, Perez‐Escuredo, Jhudit, Hermosilla, Maria Ana, Oro, Patricia, Rey, Veronica, Tornin, Juan, Allonca, Eva, Fernandez‐Garcia, Maria Teresa, Alvarez‐Fernandez, Carlos, Braña, Alejandro, Astudillo, Aurora, Menendez, Sofia T, Moris, Francisco, Rodriguez, Rene

“…Cytotoxic drugs like doxorubicin remain as the most utilized agents in sarcoma treatment. However, advanced sarcomas are often resistant, thus stressing the…”
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Cold atmospheric plasma enhances doxorubicin selectivity in metastasic bone cancer by Mateu-Sanz, Miguel, Ginebra, María-Pau, Tornín, Juan, Canal, Cristina

“…High-dose systemic chemotherapy constitutes a main strategy in the management of bone metastases, employing drugs like doxorubicin (DOX), related with severe…”
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Osteosarcoma tissue-engineered model challenges oxidative stress therapy revealing promoted cancer stem cell properties by Tornín, Juan, Villasante, Aranzazu, Solé-Martí, Xavi, Ginebra, Maria-Pau, Canal, Cristina

“…The use of oxidative stress generated by Cold Atmospheric Plasma (CAP) in oncology is being recently studied as a novel potential anti-cancer therapy. However,…”
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Exploring the Use of Cold Atmospheric Plasma to Overcome Drug Resistance in Cancer by Murillo, Dzohara, Huergo, Carmen, Gallego, Borja, Rodríguez, René, Tornín, Juan

“…Drug resistance is a major problem in cancer treatment, as it limits the effectiveness of pharmacological agents and can lead to disease progression. Cold…”
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Cold Plasma-Treated Ringer's Saline: A Weapon to Target Osteosarcoma by Mateu-Sanz, Miguel, Tornín, Juan, Brulin, Bénédicte, Khlyustova, Anna, Ginebra, Maria-Pau, Layrolle, Pierre, Canal, Cristina

“…Osteosarcoma (OS) is the main primary bone cancer, presenting poor prognosis and difficult treatment. An innovative therapy may be found in cold plasmas, which…”
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Cold plasma-treated medium preferentially eliminates doxorubicin-resistant osteosarcoma cells by Tornín, Juan, Gallego, Borja, Rey, Verónica, Murillo, Dzohara, Huergo, Carmen, Rodríguez, Aida, Canal, Cristina, Rodríguez, René

“…Osteosarcoma (OS) is an aggressive bone cancer with poor prognosis, largely due to the limited effectiveness of current treatments such as doxorubicin (DX)…”
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Cold Atmospheric Plasma: A New Strategy Based Primarily on Oxidative Stress for Osteosarcoma Therapy by Mateu-Sanz, Miguel, Tornín, Juan, Ginebra, Maria-Pau, Canal, Cristina

“…Osteosarcoma is the most common primary bone tumor, and its first line of treatment presents a high failure rate. The 5-year survival for children and…”
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Addressing Doxorubicin Resistance in Bone Sarcomas Using Novel Drug-Resistant Models by Gallego, Borja, Murillo, Dzohara, Rey, Verónica, Huergo, Carmen, Estupiñán, Óscar, Rodríguez, Aida, Tornín, Juan, Rodríguez, René

“…Bone sarcomas have not shown a significant improvement in survival for decades, due, in part, to the development of resistance to current systemic treatments,…”
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Cold plasma and inhibition of STAT3 selectively target tumorigenicity in osteosarcoma by Tornín, Juan, Mateu-Sanz, Miguel, Rey, Verónica, Murillo, Dzohara, Huergo, Carmen, Gallego, Borja, Rodríguez, Aida, Rodríguez, René, Canal, Cristina

“…Osteosarcoma (OS) is a malignant type of bone cancer that arises in periods of increased bone formation. Curative strategies for these types of tumors have…”
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Abrogation of stemness in osteosarcoma by the mithramycin analog EC-8042 is mediated by its ability to inhibit NOTCH-1 signaling by Estupiñán, Óscar, Rey, Verónica, Tornín, Juan, Murillo, Dzohara, Gallego, Borja, Huergo, Carmen, Blanco-Lorenzo, Verónica, Victoria González, M., Rodríguez, Aida, Moris, Francisco, González, Jessica, Ayllón, Verónica, Ramos-Mejía, Verónica, Bigas, Anna, Rodríguez, René

“…Osteosarcomas are frequently associated to a poor prognosis and a modest response to current treatments. EC-8042 is a well-tolerated mithramycin analog that…”
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