Search Results - "Tormoen, Garth W"

Role of the immunosuppressive microenvironment in immunotherapy by Tormoen, Garth W., MD, PhD, Crittenden, Marka R., MD, PhD, Gough, Michael J., PhD

“…Abstract Immunotherapy is reshaping cancer treatment paradigms; however, response rates to immune therapies are low and depend on the host's pre-existing…”
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The prothrombotic activity of cancer cells in the circulation by Mitrugno, Annachiara, Tormoen, Garth W, Kuhn, Peter, McCarty, Owen J.T

“…Abstract The hemostatic system is often subverted in patients with cancer, resulting in life-threatening venous thrombotic events. Despite the multifactorial…”
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Dendritic Cell Maturation Defines Immunological Responsiveness of Tumors to Radiation Therapy by Blair, Tiffany C, Bambina, Shelly, Alice, Alejandro F, Kramer, Gwen F, Medler, Terry R, Baird, Jason R, Broz, Miranda L, Tormoen, Garth W, Troesch, Victoria, Crittenden, Marka R, Gough, Michael J

“…Radiation therapy is capable of directing adaptive immune responses against tumors by stimulating the release of endogenous adjuvants and tumor-associated Ags…”
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Microfluidics and coagulation biology by Colace, Thomas V, Tormoen, Garth W, McCarty, Owen J T, Diamond, Scott L

“…The study of blood ex vivo can occur in closed or open systems, with or without flow. Microfluidic devices, which constrain fluids to a small (typically…”
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The Predictive Value of Inflammation-Related Peripheral Blood Measurements in Cancer Staging and Prognosis by Sylman, Joanna L, Mitrugno, Annachiara, Atallah, Michelle, Tormoen, Garth W, Shatzel, Joseph J, Tassi Yunga, Samuel, Wagner, Todd H, Leppert, John T, Mallick, Parag, McCarty, Owen J T

“…In this review, we discuss the interaction between cancer and markers of inflammation (such as levels of inflammatory cells and proteins) in the circulation,…”
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S6K1 and mTOR regulate Rac1-driven platelet activation and aggregation by Aslan, Joseph E., Tormoen, Garth W., Loren, Cassandra P., Pang, Jiaqing, McCarty, Owen J.T.

“…Platelet activation and thrombus formation are under the control of signaling systems that integrate cellular homeostasis with cytoskeletal dynamics. Here, we…”
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Molecular Imaging of Activated von Willebrand Factor to Detect High-Risk Atherosclerotic Phenotype by McCarty, Owen J.T., PhD, Conley, Robert B., BS, Shentu, Weihui, MD, Tormoen, Garth W., MS, Zha, Daogang, MD, Xie, Aris, BS, Qi, Yue, MD, Zhao, Yan, MD, Carr, Chad, MD, Belcik, Todd, RDCS, Keene, Douglas R., BS, de Groot, Philip G., PhD, Lindner, Jonathan R., MD

“…Objectives We hypothesized that noninvasive molecular imaging of activated von Willebrand factor (vWF) on the vascular endothelium could be used to detect a…”
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Do circulating tumor cells play a role in coagulation and thrombosis? by Tormoen, Garth W, Haley, Kristina M, Levine, Ross L, McCarty, Owen J T

“…Cancer induces a hypercoagulable state, and patients with cancer who suffer a thrombotic event have a worse prognosis than those who do not. Recurrent…”
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Development of coagulation factor probes for the identification of procoagulant circulating tumor cells by Tormoen, Garth W, Cianchetti, Flor A, Bock, Paul E, McCarty, Owen J T

“…Metastatic cancer is associated with a hypercoagulable state, and pathological venous thromboembolic disease is a significant source of morbidity and the…”
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Targeting MerTK Enhances Adaptive Immune Responses After Radiation Therapy by Tormoen, Garth W., Blair, Tiffany C., Bambina, Shelly, Kramer, Gwen, Baird, Jason, Rahmani, Ramtin, Holland, John M., McCarty, Owen J.T., Baine, Michael J., Verma, Vivek, Nabavizadeh, Nima, Gough, Michael J., Crittenden, Marka

“…The role of MerTK, a member of the Tyro3-Axl-MerTK family of receptor tyrosine kinase, in the immune response to radiation therapy (RT) is unclear. We…”
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A Temporal Examination of Platelet Counts as a Predictor of Prognosis in Lung, Prostate, and Colon Cancer Patients by Sylman, Joanna L., Boyce, Hunter B., Mitrugno, Annachiara, Tormoen, Garth W., Thomas, I-Chun, Wagner, Todd H., Lee, Jennifer S., Leppert, John T., McCarty, Owen J. T., Mallick, Parag

“…Platelets, components of hemostasis, when present in excess (>400 K/μL, thrombocytosis) have also been associated with worse outcomes in lung, ovarian, breast,…”
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Deformation of soft colloidal probes during AFM pull-off force measurements: elimination of nano-roughness effects by Tormoen, Garth W., Drelich, Jaroslaw

“…The forces needed to remove polystyrene (PS) and polyethylene (PE) particles from silicon wafers were measured using the atomic force microscopy colloidal…”
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Molecular imaging of inflammation and platelet adhesion in advanced atherosclerosis effects of antioxidant therapy with NADPH oxidase inhibition by Liu, Yani, Davidson, Brian P, Yue, Qi, Belcik, Todd, Xie, Aris, Inaba, Yoichi, McCarty, Owen J T, Tormoen, Garth W, Zhao, Yan, Ruggeri, Zaverio M, Kaufmann, Beat A, Lindner, Jonathan R

“…In atherosclerosis, local generation of reactive oxygen species amplifies the inflammatory response and contributes to plaque vulnerability. We used molecular…”
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The thrombotic potential of circulating tumor microemboli: computational modeling of circulating tumor cell-induced coagulation by Phillips, Kevin G, Lee, Angela M, Tormoen, Garth W, Rigg, Rachel A, Kolatkar, Anand, Luttgen, Madelyn, Bethel, Kelly, Bazhenova, Lyudmila, Kuhn, Peter, Newton, Paul, McCarty, Owen J T

“…Thrombotic events can herald the diagnosis of cancer, preceding any cancer-related clinical symptoms. Patients with cancer are at a 4- to 7-fold increased risk…”
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Exogenous modification of platelet membranes with the omega-3 fatty acids EPA and DHA reduces platelet procoagulant activity and thrombus formation by Larson, Mark K, Tormoen, Garth W, Weaver, Lucinda J, Luepke, Kristen J, Patel, Ishan A, Hjelmen, Carl E, Ensz, Nicole M, McComas, Leah S, McCarty, Owen J T

“…Several studies have implicated the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in inhibition of normal platelet function,…”
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p21 Activated Kinase Signaling Coordinates Glycoprotein Receptor VI–Mediated Platelet Aggregation, Lamellipodia Formation, and Aggregate Stability Under Shear by Aslan, Joseph E, Itakura, Asako, Haley, Kristina M, Tormoen, Garth W, Loren, Cassandra P, Baker, Sandra M, Pang, Jiaqing, Chernoff, Jonathan, McCarty, Owen J.T

“…OBJECTIVE—Rho GTPase proteins play a central role in regulating the dynamics of the platelet actin cytoskeleton. Yet, little is known regarding how Rho GTPase…”
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Determination of solid surface tension from particle–substrate pull-off forces measured with the atomic force microscope by Drelich, Jaroslaw, Tormoen, Garth W., Beach, Elvin R.

“…Atomic force microscopy (AFM) is capable of solid surface characterization at the microscopic and submicroscopic scales. It can also be used for the…”
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Physiological levels of blood coagulation factors IX and X control coagulation kinetics in an in vitro model of circulating tissue factor by Tormoen, Garth W, Khader, Ayesha, Gruber, András, McCarty, Owen J T

“…Thrombosis significantly contributes to cancer morbidity and mortality. The mechanism behind thrombosis in cancer may be circulating tissue factor (TF), as…”
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Phosphatidylserine index as a marker of the procoagulant phenotype of acute myelogenous leukemia cells by Tormoen, Garth W, Recht, Olivia, Gruber, András, Levine, Ross L, McCarty, Owen J T

“…Patients with acute myelogenous leukemia (AML) are at risk for thrombotic complications. Risk to develop thrombosis is closely tied to leukemia subtype, and…”
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Effect of Ionizing Radiation on the Physical Biology of Head and Neck Squamous Cell Carcinoma Cells by Baker-Groberg, Sandra M., Bornstein, Sophia, Zilberman-Rudenko, Jevgenia, Schmidt, Mark, Tormoen, Garth W., Kernan, Casey, Thomas, Charles R., Wong, Melissa H., Phillips, Kevin G., McCarty, Owen J. T.

“…Head and neck squamous cell carcinoma (HNSCC) is the sixth leading cause of cancer worldwide. Although there are numerous treatment options for HNSCC, such as…”
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