Search Results - "Tormo, Jose R."

Fungal endophytes from arid areas of Andalusia: high potential sources for antifungal and antitumoral agents by González-Menéndez, Victor, Crespo, Gloria, de Pedro, Nuria, Diaz, Caridad, Martín, Jesús, Serrano, Rachel, Mackenzie, Thomas A., Justicia, Carlos, González-Tejero, M. Reyes, Casares, M., Vicente, Francisca, Reyes, Fernando, Tormo, José R., Genilloud, Olga

“…Native plant communities from arid areas present distinctive characteristics to survive in extreme conditions. The large number of poorly studied endemic…”
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Cyclic Colisporifungin and Linear Cavinafungins, Antifungal Lipopeptides Isolated from Colispora cavincola by Ortíz-López, Francisco Javier, Monteiro, Maria Cândida, González-Menéndez, Víctor, Tormo, José R, Genilloud, Olga, Bills, Gerald F, Vicente, Francisca, Zhang, Chaowei, Roemer, Terry, Singh, Sheo B, Reyes, Fernando

“…Colisporifungin (1), a cyclic depsilipopeptide structurally related to the aselacins, and cavinafungins A and B, two linear peptides, were isolated from liquid…”
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Discovery of bioactive natural products of microbial origin as inhibitors of the PD-1/PD-L1 protein-protein interaction by Domingo-Contreras, Elisabeth, Tormo, José R., Gonzalez-Menendez, Victor, Mackenzie, Thomas A., Martín-Serrano, Jesús, Magiera-Mularz, Katarzyna, Kitel, Radoslaw, Reyes, Fernando, Genilloud, Olga, Fernández-Godino, Rosario, Ramos, Maria C., Castillo, Francisco

“…The PD-1/PD-L1 protein-protein interaction (PPI) controls an adaptive immune resistance mechanism exerted by tumor cells to evade immune responses. The…”
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A new approach to drug discovery: high-throughput screening of microbial natural extracts against Aspergillus fumigatus using resazurin by Monteiro, Maria Cândida, de la Cruz, Mercedes, Cantizani, Juan, Moreno, Catalina, Tormo, José R, Mellado, Emilia, De Lucas, J Ramón, Asensio, Francisco, Valiante, Vito, Brakhage, Axel A, Latgé, Jean-Paul, Genilloud, Olga, Vicente, Francisca

“…Natural products are an inexhaustible source for drug discovery. However, the validation and selection of primary screening assays are vital to guarantee a…”
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Onychocolone A produced by the fungus Onychocola sp. targets cancer stem cells and stops pancreatic cancer progression by inhibiting MEK2-dependent cell signaling by Ramos, Maria C., Crespo-Sueiro, Gloria, de Pedro, Nuria, Griñán-Lisón, Carmen, Díaz, Caridad, Pérez-Victoria, Ignacio, González-Menéndez, Víctor, Castillo, Francisco, Pérez del Palacio, Jose, Tormo, Jose R., Choquesillo-Lazarte, Duane, Marchal, Juan A., Vicente, Francisca, Fernández-Godino, Rosario, Genilloud, Olga, Reyes, Fernando

“…Pancreatic cancer (PC) shows a high fatality rate that can only be faced with a combination of surgery and chemotherapy or palliative treatment in the case of…”
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Development and Validation of a HTS Platform for the Discovery of New Antifungal Agents against Four Relevant Fungal Phytopathogens by Serrano, Rachel, González-Menéndez, Víctor, Tormo, José R, Genilloud, Olga

“…Fungal phytopathogens are the major agents responsible for causing severe damage to and losses in agricultural crops worldwide. Botrytis cinerea,…”
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Kocurin, the true structure of PM181104, an anti-methicillin-resistant Staphylococcus aureus (MRSA) thiazolyl peptide from the marine-derived bacterium Kocuria palustris by Martín, Jesús, da S Sousa, Thiciana, Crespo, Gloria, Palomo, Sara, González, Ignacio, Tormo, José R, de la Cruz, Mercedes, Anderson, Matthew, Hill, Russell T, Vicente, Francisca, Genilloud, Olga, Reyes, Fernando

“…A new thiazolyl peptide, kocurin (1), was isolated from culture broths of a marine-derived Kocuria palustris. Its structural elucidation was accomplished using…”
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Biological Evaluation and In Silico Study of Benzoic Acid Derivatives from Bjerkandera adusta Targeting Proteostasis Network Modules by Georgousaki, Katerina, Tsafantakis, Nikolaos, Gumeni, Sentiljana, Lambrinidis, George, González-Menéndez, Victor, Tormo, Jose R, Genilloud, Olga, Trougakos, Ioannis P, Fokialakis, Nikolas

“…: A main cellular functional module that becomes dysfunctional during aging is the proteostasis network. In the present study, we show that benzoic acid…”
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Bioactivities and Extract Dereplication of Actinomycetales Isolated From Marine Sponges by Santos, José D, Vitorino, Inês, De la Cruz, Mercedes, Díaz, Caridad, Cautain, Bastien, Annang, Frederick, Pérez-Moreno, Guiomar, Gonzalez Martinez, Ignacio, Tormo, Jose R, Martín, Jesús M, Urbatzka, Ralph, Vicente, Francisca M, Lage, Olga M

“…In the beginning of the twenty-first century, humanity faces great challenges regarding diseases and health-related quality of life. A drastic rise in…”
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Hitting the caspofungin salvage pathway of human-pathogenic fungi with the novel lasso peptide humidimycin (MDN-0010) by Valiante, Vito, Monteiro, Maria Cândida, Martín, Jesús, Altwasser, Robert, El Aouad, Noureddine, González, Ignacio, Kniemeyer, Olaf, Mellado, Emilia, Palomo, Sara, de Pedro, Nuria, Pérez-Victoria, Ignacio, Tormo, José R, Vicente, Francisca, Reyes, Fernando, Genilloud, Olga, Brakhage, Axel A

“…Fungal infections have increased dramatically in the last 2 decades, and fighting infectious diseases requires innovative approaches such as the combination of…”
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Production of Ramoplanin and Ramoplanin Analogs by Actinomycetes by de la Cruz, Mercedes, González, Ignacio, Parish, Craig A, Onishi, Russell, Tormo, José R, Martín, Jesús, Peláez, Fernando, Zink, Debbie, El Aouad, Noureddine, Reyes, Fernando, Genilloud, Olga, Vicente, Francisca

“…Ramoplanin is a glycolipodepsipeptide antibiotic obtained from fermentation of sp. ATCC 33076 that exhibits activity against clinically important…”
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Biodiversity and chemotaxonomy of Preussia isolates from the Iberian Peninsula by Gonzalez-Menendez, Víctor, Martin, Jesus, Siles, Jose A., Gonzalez-Tejero, M. Reyes, Reyes, Fernando, Platas, Gonzalo, Tormo, Jose R., Genilloud, Olga

“…This work documents 32 new Preussia isolates from the Iberian Peninsula, including endophytic and saprobic strains. The morphological study of the teleomorphs…”
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High-Throughput Screening Platform for the Discovery of New Immunomodulator Molecules from Natural Product Extract Libraries by Pérez Del Palacio, José, Díaz, Caridad, de la Cruz, Mercedes, Annang, Frederick, Martín, Jesús, Pérez-Victoria, Ignacio, González-Menéndez, Víctor, de Pedro, Nuria, Tormo, José R, Algieri, Francesca, Rodriguez-Nogales, Alba, Rodríguez-Cabezas, M Elena, Reyes, Fernando, Genilloud, Olga, Vicente, Francisca, Gálvez, Julio

“…It is widely accepted that central nervous system inflammation and systemic inflammation play a significant role in the progression of chronic…”
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Extending the Metabolite Diversity of the Endophyte Dimorphosporicola tragani by González-Menéndez, Victor, Crespo, Gloria, Toro, Clara, Martín, Jesús, de Pedro, Nuria, Tormo, Jose R, Genilloud, Olga

“…Fungi are one of the most prolific sources of microbial secondary metabolites. The production of new metabolites can be achieved using multiple fermentation…”
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High-content screening of natural products reveals novel nuclear export inhibitors by Cautain, Bastien, de Pedro, Nuria, Murillo Garzón, Virginia, Muñoz de Escalona, María, González Menéndez, Victor, Tormo, José R, Martin, Jesús, El Aouad, Noureddine, Reyes, Fernando, Asensio, Francisco, Genilloud, Olga, Vicente, Francisca, Link, Wolfgang

“…Natural products are considered an extremely valuable source for the discovery of new drugs against diverse pathologies. As yet, we have only explored a…”
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A yeast-based in vivo bioassay to screen for class I phosphatidylinositol 3-kinase specific inhibitors by Fernández-Acero, Teresa, Rodríguez-Escudero, Isabel, Vicente, Francisca, Monteiro, Maria Cândida, Tormo, José R, Cantizani, Juan, Molina, María, Cid, Víctor J

“…The phosphatidylinositol 3-kinase (PI3K) pathway couples receptor-mediated signaling to essential cellular functions by generating the lipid second messenger…”
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Naphthoquinone Derivatives from Angustimassarina populi CF-097565 Display Anti-Tumour Activity in 3D Cultures of Breast Cancer Cells by Mackenzie, Thomas A, Reyes, Fernando, Martínez, Marta, González-Menéndez, Víctor, Sánchez, Isabel, Genilloud, Olga, Tormo, José R, Ramos, María C

“…Cancer is one of the leading causes of death worldwide, with breast cancer being the second cause of cancer-related mortality among women. Natural Products…”
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Metabolomic Analysis of The Chemical Diversity of South Africa Leaf Litter Fungal Species Using an Epigenetic Culture-Based Approach by Serrano, Rachel, González-Menéndez, Víctor, Martínez, Germán, Toro, Clara, Martín, Jesús, Genilloud, Olga, Tormo,  José R.

“…Microbial natural products are an invaluable resource for the biotechnological industry. Genome mining studies have highlighted the huge biosynthetic potential…”
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Interactions of Different Streptomyces Species and Myxococcus xanthus Affect Myxococcus Development and Induce the Production of DK-Xanthenes by Santamaría, Ramón I., Martínez-Carrasco, Ana, Tormo, José R., Martín, Jesús, Genilloud, Olga, Reyes, Fernando, Díaz, Margarita

“…The co-culturing of microorganisms is a well-known strategy to study microbial interactions in the laboratory. This approach facilitates the identification of…”
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Genome-Led Discovery of the Antibacterial Cyclic Lipopeptide Kutzneridine A and Its Silent Biosynthetic Gene Cluster from Kutzneria Species by Ortiz-López, Francisco Javier, Oves-Costales, Daniel, Guerrero Garzón, Jaime Felipe, Gren, Tetiana, Baggesgaard Sterndorff, Eva, Jiang, Xinglin, Sparholt Jo̷rgensen, Tue, Blin, Kai, Fernández-Pastor, Ignacio, Tormo, José R., Martín, Jesús, Sánchez, Pilar, Moreno, Mercedes de la Cruz, Reyes, Fernando, Genilloud, Olga, Weber, Tilmann

“…Genome analysis of Kutzneria sp. CA-103260 revealed a putative lipopeptide-encoding biosynthetic gene cluster (BGC) that was cloned into a bacterial artificial…”
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