Search Results - "Tormo,  José R."

Naphthoquinone Derivatives from Angustimassarina populi CF-097565 Display Anti-Tumour Activity in 3D Cultures of Breast Cancer Cells by Mackenzie, Thomas A, Reyes, Fernando, Martínez, Marta, González-Menéndez, Víctor, Sánchez, Isabel, Genilloud, Olga, Tormo, José R, Ramos, María C

“…Cancer is one of the leading causes of death worldwide, with breast cancer being the second cause of cancer-related mortality among women. Natural Products…”
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Metabolomic Analysis of The Chemical Diversity of South Africa Leaf Litter Fungal Species Using an Epigenetic Culture-Based Approach by Serrano, Rachel, González-Menéndez, Víctor, Martínez, Germán, Toro, Clara, Martín, Jesús, Genilloud, Olga, Tormo,  José R.

“…Microbial natural products are an invaluable resource for the biotechnological industry. Genome mining studies have highlighted the huge biosynthetic potential…”
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Interactions of Different Streptomyces Species and Myxococcus xanthus Affect Myxococcus Development and Induce the Production of DK-Xanthenes by Santamaría, Ramón I., Martínez-Carrasco, Ana, Tormo, José R., Martín, Jesús, Genilloud, Olga, Reyes, Fernando, Díaz, Margarita

“…The co-culturing of microorganisms is a well-known strategy to study microbial interactions in the laboratory. This approach facilitates the identification of…”
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Genome-Led Discovery of the Antibacterial Cyclic Lipopeptide Kutzneridine A and Its Silent Biosynthetic Gene Cluster from Kutzneria Species by Ortiz-López, Francisco Javier, Oves-Costales, Daniel, Guerrero Garzón, Jaime Felipe, Gren, Tetiana, Baggesgaard Sterndorff, Eva, Jiang, Xinglin, Sparholt Jo̷rgensen, Tue, Blin, Kai, Fernández-Pastor, Ignacio, Tormo, José R., Martín, Jesús, Sánchez, Pilar, Moreno, Mercedes de la Cruz, Reyes, Fernando, Genilloud, Olga, Weber, Tilmann

“…Genome analysis of Kutzneria sp. CA-103260 revealed a putative lipopeptide-encoding biosynthetic gene cluster (BGC) that was cloned into a bacterial artificial…”
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Delftia tsuruhatensis TC1 symbiont suppresses malaria transmission by anopheline mosquitoes by Huang, Wei, Rodrigues, Janneth, Bilgo, Etienne, Tormo, José R, Challenger, Joseph D, De Cozar-Gallardo, Cristina, Pérez-Victoria, Ignacio, Reyes, Fernando, Castañeda-Casado, Pablo, Gnambani, Edounou Jacques, Hien, Domonbabele François de Sales, Konkobo, Maurice, Urones, Beatriz, Coppens, Isabelle, Mendoza-Losana, Alfonso, Ballell, Lluís, Diabate, Abdoulaye, Churcher, Thomas S, Jacobs-Lorena, Marcelo

“…Malaria control demands the development of a wide range of complementary strategies. We describe the properties of a naturally occurring, non-genetically…”
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Multicomponent Analysis of the Differential Induction of Secondary Metabolite Profiles in Fungal Endophytes by González-Menéndez, Víctor, Pérez-Bonilla, Mercedes, Pérez-Victoria, Ignacio, Martín, Jesús, Muñoz, Francisca, Reyes, Fernando, Tormo, José R, Genilloud, Olga

“…Small molecule histone deacetylase (HDAC) and DNA methyltransferase (DNMT) inhibitors are commonly used to perturb the production of fungal metabolites leading…”
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Comoclathrin, a novel potent skin-whitening agent produced by endophytic Comoclathris strains associated with Andalusia desert plants by Georgousaki, Katerina, González-Menéndez, Victor, Tormo, José R., Tsafantakis, Nikolaos, Mackenzie, Thomas A., Martín, Jesús, Gumeni, Sentiljana, Trougakos, Ioannis P., Reyes, Fernando, Fokialakis, Nikolas, Genilloud, Olga

“…As part of our screening program for the discovery of molecules of microbial origin with skin-whitening activity, 142 diverse fungal endophytes from a wide…”
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Identification of novel small molecule-based strategies of COL7A1 upregulation and readthrough activity for the treatment of recessive dystrophic epidermolysis bullosa by Jover, Irene, Ramos, Maria C., Escámez, María José, Lozoya, Estrella, Tormo, José R., de Prado-Verdún, Diana, Mencía, Ángeles, Pont, Mercè, Puig, Carles, Larraufie, Marie-Helene, Gutiérrez-Caballero, Cristina, Reyes, Fernando, Trincado, Juan Luis, García-González, Vicente, Cerrato, Rosario, Andrés, Miriam, Crespo, Maribel, Vicente, Francisca, Godessart, Nuria, Genilloud, Olga, Larcher, Fernando, Nueda, Arsenio

“…Recessive dystrophic epidermolysis bullosa (RDEB) is a rare genetic disease caused by loss of function mutations in the gene coding for collagen VII (C7) due…”
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Activation and Identification of a Griseusin Cluster in Streptomyces sp. CA-256286 by Employing Transcriptional Regulators and Multi-Omics Methods by Beck, Charlotte, Gren, Tetiana, Ortiz-López, Francisco Javier, Jørgensen, Tue Sparholt, Carretero-Molina, Daniel, Martín Serrano, Jesús, Tormo, José R, Oves-Costales, Daniel, Kontou, Eftychia E, Mohite, Omkar S, Mingyar, Erik, Stegmann, Evi, Genilloud, Olga, Weber, Tilmann

“…are well-known producers of a range of different secondary metabolites, including antibiotics and other bioactive compounds. Recently, it has been demonstrated…”
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Madurastatins with Imidazolidinone Rings: Natural Products or Side-Reaction Products from Extraction Solvents? by Pérez-Bonilla, Mercedes, Sánchez-Hidalgo, Marina, González, Ignacio, Oves-Costales, Daniel, Martín, Jesús, Murillo-Alba, José, Tormo, José R, Cho, Ahreum, Byun, Soo-Young, No, Joo-Hwan, Shum, David, Ioset, Jean-Robert, Genilloud, Olga, Reyes, Fernando

“…Madurastatins are a group of pentapeptides containing an oxazoline moiety, and, in a few cases, an imidazolidinone ring as an additional structural feature. In…”
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Kribbellichelins A and B, Two New Antibiotics from Kribbella sp. CA-293567 with Activity against Several Human Pathogens by Virués-Segovia, Jorge R., Reyes, Fernando, Ruíz, Sandra, Martín, Jesús, Fernández-Pastor, Ignacio, Justicia, Carlos, de la Cruz, Mercedes, Díaz, Caridad, Mackenzie, Thomas A., Genilloud, Olga, González, Ignacio, Tormo, José R.

“…Current needs in finding new antibiotics against emerging multidrug-resistant superbugs are pushing the scientific community into coming back to Nature for the…”
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Co-culturing of Fungal Strains Against Botrytis cinerea as a Model for the Induction of Chemical Diversity and Therapeutic Agents by Serrano, Rachel, González-Menéndez, Víctor, Rodríguez, Lorena, Martín, Jesús, Tormo, José R, Genilloud, Olga

“…New fungal SMs (SMs) have been successfully described to be produced by means of -simulated microbial community interactions. Co-culturing of fungi has proved…”
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Acoustic droplet ejection facilitates cell-based high-throughput screenings using natural products by Mackenzie, Thomas A., Tormo, José R., Cautain, Bastien, Martínez, Germán, Sánchez, Isabel, Genilloud, Olga, Vicente, Francisca, Ramos, Maria C.

“…•Natural Products (NPs) are one of the most important sources for drug discovery.•Novel High-Throughput Screening (HTS) technologies improve the use of samples…”
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Ultraviolet (IUV) and mass spectrometry (IMS) imaging for the deconvolution of microbial interactions by González-Menéndez, Víctor, Martínez, Germán, Serrano, Rachel, Muñoz, Francisca, Martín, Jesús, Genilloud, Olga, Tormo, José R

“…Spatial localization of natural products or proteins during microbial interactions can help to identify new antimicrobials both as offensive or defensive…”
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Hormonemate Derivatives from Dothiora sp., an Endophytic Fungus by Pérez-Bonilla, Mercedes, González-Menéndez, Víctor, Pérez-Victoria, Ignacio, de Pedro, Nuria, Martín, Jesús, Molero-Mesa, Joaquín, Casares-Porcel, Manuel, González-Tejero, María Reyes, Vicente, Francisca, Genilloud, Olga, Tormo, José R, Reyes, Fernando

“…A search for cytotoxic agents from cultures of the endophytic fungus Dothiora sp., isolated from the endemic plant Launaea arborescens, led to the isolation of…”
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Grapevine Xylem Sap Is a Potent Elicitor of Antibiotic Production in Streptomyces spp by Santamaría, Ramón I, Martínez-Carrasco, Ana, Martín, Jesús, Tormo, José R, Pérez-Victoria, Ignacio, González, Ignacio, Genilloud, Olga, Reyes, Fernando, Díaz, Margarita

“…bacteria produce a wide number of antibiotics and antitumor compounds that have attracted the attention of pharmaceutical and biotech companies. In this study,…”
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Development of a Drosophila melanogaster spliceosensor system for in vivo high-throughput screening in myotonic dystrophy type 1 by García-Alcover, Irma, Colonques-Bellmunt, Jordi, Garijo, Raquel, Tormo, José R, Artero, Rubén, Álvarez-Abril, Mari Carmen, López Castel, Arturo, Pérez-Alonso, Manuel

“…Alternative splicing of pre-mRNAs is an important mechanism that regulates cellular function in higher eukaryotes. A growing number of human genetic diseases…”
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Time-Dependent Production of the Bioactive Peptides Endolides A and B and the Polyketide Mariline A from the Sponge-Derived Fungus Stachylidium bicolor 293K04 by Almeida, Celso, Bills, Gerald, González-Menéndez, Víctor, Martin, Jesús, Tormo, José R., Genilloud, Olga

“…Previous investigations of the sponge-derived fungus Stachylidium bicolor (S. bicolor) 293K04 led to the isolation of the biosynthetically unusual polyketides…”
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New antitumoral acetogenin ‘Guanacone type’ derivatives: Isolation and bioactivity. Molecular dynamics simulation of diacetyl-guanacone by Barrachina, Isabel, Royo, Inmaculada, Baldoni, Héctor A., Chahboune, Nadia, Suvire, Fernando, DePedro, Nuria, Zafra-Polo, M. Carmen, Bermejo, Almudena, El Aouad, Noureddine, Cabedo, Nuria, Saez, Jairo, Tormo, José R., Enriz, Ricardo D., Cortes, Diego

“…We describe herein the isolation and semisynthesis of four acetogenin derivatives ( 1– 4) as well as their ability to inhibit the mitochondrial respiratory…”
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Fungal endophytes from arid areas of Andalusia: high potential sources for antifungal and antitumoral agents by González-Menéndez, Victor, Crespo, Gloria, de Pedro, Nuria, Diaz, Caridad, Martín, Jesús, Serrano, Rachel, Mackenzie, Thomas A., Justicia, Carlos, González-Tejero, M. Reyes, Casares, M., Vicente, Francisca, Reyes, Fernando, Tormo, José R., Genilloud, Olga

“…Native plant communities from arid areas present distinctive characteristics to survive in extreme conditions. The large number of poorly studied endemic…”
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