Evaluation of sepsis/systemic inflammatory response syndrome, acute kidney injury, and RIFLE criteria in two tertiary hospital intensive care units in Turkey

Sepsis is a common cause of acute renal failure in intensive care units (ICU) with mortality rates as high as 60%. In this study, the clinical and laboratory predictors of acute kidney injury (AKI) in critically ill Turkish patients with sepsis/systemic inflammatory response syndrome were identified...

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Bibliographic Details
Published in:	Nephron. Clinical practice Vol. 115; no. 4; p. c276
Main Authors:	Yegenaga, Itir, Tuglular, Serhan, Ari, Elif, Etiler, Nilay, Baykara, Nur, Torlak, Sinan, Acar, Sertan, Akbas, Turkay, Toker, Kamil, Solak, Zeynep Mine
Format:	Journal Article
Language:	English
Published:	Switzerland 01-07-2010
Subjects:	Acute Kidney Injury - diagnosis Acute Kidney Injury - mortality Comorbidity Female Health Status Indicators Humans Intensive Care Units - statistics & numerical data Male Middle Aged Prevalence Risk Assessment - methods Risk Factors Sepsis - diagnosis Sepsis - mortality Survival Analysis Survival Rate Systemic Inflammatory Response Syndrome - diagnosis Systemic Inflammatory Response Syndrome - mortality Turkey - epidemiology Turkey
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Summary:	Sepsis is a common cause of acute renal failure in intensive care units (ICU) with mortality rates as high as 60%. In this study, the clinical and laboratory predictors of acute kidney injury (AKI) in critically ill Turkish patients with sepsis/systemic inflammatory response syndrome were identified. We studied 139 (67 females/72 males) patients admitted to our ICUs with sepsis/systemic inflammatory response syndrome without renal failure. The clinical and laboratory parameters and treatments were recorded. Patients were classified as those without AKI (n = 60; 43.20%) and those with AKI (n = 79; 56.80%) based on the RIFLE (Risk, Injury, Failure, Loss, End-stage renal disease) criteria. Those with AKI were further classified as: risk in 27 (19%), injury in 25 (17.9%), failure in 25 (17.9%), and loss in 2 (1.4%). We found that the mortality rate increased with the severity of renal involvement: 56% in risk, 68% in injury, 72% in failure, and 100% in loss categories. Patients with AKI had a more positive fluid balance, higher central venous pressure, more vasopressor use, and lower systolic blood pressure. In multivariate analysis, the sequential organ failure assessment score, blood pressure, serum creatinine, and fluid balance were risk factors for the development of AKI. In this population, the incidence of AKI was higher and contrary to previous knowledge. A positive fluid balance also carries a risk for AKI and mortality in septic ICU patients. The RIFLE criteria were found to be applicable to our ICU population.
ISSN:	1660-2110
DOI:	10.1159/000313486