Search Results - "Torkler, Phillipp"

PROSO II – a new method for protein solubility prediction by Smialowski, Pawel, Doose, Gero, Torkler, Phillipp, Kaufmann, Stefanie, Frishman, Dmitrij

“…Many fields of science and industry depend on efficient production of active protein using heterologous expression in Escherichia coli. The solubility of…”
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Clinical utility of the exosome based ExoDx Prostate(IntelliScore) EPI test in men presenting for initial Biopsy with a PSA 2–10 ng/mL by Tutrone, Ronald, Donovan, Michael J., Torkler, Phillipp, Tadigotla, Vasisht, McLain, Tom, Noerholm, Mikkel, Skog, Johan, McKiernan, James

“…Background The ExoDx Prostate( IntelliScore ) (EPI) test is a non-invasive risk assessment tool for detection of high-grade prostate cancer (HGPC) that informs…”
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LoDEI: a robust and sensitive tool to detect transcriptome-wide differential A-to-I editing in RNA-seq data by Torkler, Phillipp, Sauer, Marina, Schwartz, Uwe, Corbacioglu, Selim, Sommer, Gunhild, Heise, Tilman

“…RNA editing is a highly conserved process. Adenosine deaminase acting on RNA (ADAR) mediated deamination of adenosine (A-to-I editing) is associated with human…”
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Transcriptome Surveillance by Selective Termination of Noncoding RNA Synthesis by Schulz, Daniel, Schwalb, Bjoern, Kiesel, Anja, Baejen, Carlo, Torkler, Phillipp, Gagneur, Julien, Soeding, Johannes, Cramer, Patrick

“…Pervasive transcription of eukaryotic genomes stems to a large extent from bidirectional promoters that synthesize mRNA and divergent noncoding RNA (ncRNA)…”
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Transcriptome Maps of mRNP Biogenesis Factors Define Pre-mRNA Recognition by Baejen, Carlo, Torkler, Phillipp, Gressel, Saskia, Essig, Katharina, Söding, Johannes, Cramer, Patrick

“…Biogenesis of eukaryotic messenger ribonucleoprotein complexes (mRNPs) involves the synthesis, splicing, and 3′ processing of pre-mRNA, and the assembly of…”
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Validation of a CE-IVD, urine exosomal RNA expression assay for risk assessment of prostate cancer prior to biopsy by Kretschmer, Alexander, Kajau, Holger, Margolis, Eric, Tutrone, Ronald, Grimm, Tobias, Trottmann, Matthias, Stief, Christian, Stoll, Georg, Fischer, Christian A., Flinspach, Claudia, Albrecht, Anja, Meyer, Lisa, Priewasser, Tina, Enderle, Daniel, Müller, Romy, Torkler, Phillipp, Alter, Jason, Skog, Johan, Noerholm, Mikkel

“…Improved risk stratification of patients suspected of prostate cancer prior to biopsy continues to be an unmet clinical need. ExoDx Prostate (IntelliScore)…”
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Genome-wide Analysis of RNA Polymerase II Termination at Protein-Coding Genes by Baejen, Carlo, Andreani, Jessica, Torkler, Phillipp, Battaglia, Sofia, Schwalb, Bjoern, Lidschreiber, Michael, Maier, Kerstin C., Boltendahl, Andrea, Rus, Petra, Esslinger, Stephanie, Söding, Johannes, Cramer, Patrick

“…At the end of protein-coding genes, RNA polymerase (Pol) II undergoes a concerted transition that involves 3′-processing of the pre-mRNA and transcription…”
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Pre-diagnosis urine exosomal RNA (ExoDx EPI score) is associated with post-prostatectomy pathology outcome by Kretschmer, Alexander, Tutrone, Ronald, Alter, Jason, Berg, Elena, Fischer, Christian, Kumar, Sonia, Torkler, Phillipp, Tadigotla, Vasisht, Donovan, Michael, Sant, Grannum, Skog, Johan, Noerholm, Mikkel

“…Purpose ExoDx Prostate IntelliScore (EPI) is a non-invasive urine exosome RNA-based test for risk assessment of high-grade prostate cancer. We evaluated the…”
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RNA-dependent chromatin association of transcription elongation factors and Pol II CTD kinases by Battaglia, Sofia, Lidschreiber, Michael, Baejen, Carlo, Torkler, Phillipp, Vos, Seychelle M, Cramer, Patrick

“…For transcription through chromatin, RNA polymerase (Pol) II associates with elongation factors (EFs). Here we show that many EFs crosslink to RNA emerging…”
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A urine-based Exosomal gene expression test stratifies risk of high-grade prostate Cancer in men with prior negative prostate biopsy undergoing repeat biopsy by McKiernan, James, Noerholm, Mikkel, Tadigotla, Vasisht, Kumar, Sonia, Torkler, Phillipp, Sant, Grannum, Alter, Jason, Donovan, Michael J, Skog, Johan

“…Abstract Background Initial prostate biopsy often fails to identify prostate cancer resulting in patient anxiety, especially when clinical features such as…”
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A Prospective Adaptive Utility Trial to Validate Performance of a Novel Urine Exosome Gene Expression Assay to Predict High-grade Prostate Cancer in Patients with Prostate-specific Antigen 2–10 ng/ml at Initial Biopsy by McKiernan, James, Donovan, Michael J., Margolis, Eric, Partin, Alan, Carter, Ballentine, Brown, Gordon, Torkler, Phillipp, Noerholm, Mikkel, Skog, Johan, Shore, Neal, Andriole, Gerry, Thompson, Ian, Carroll, Peter

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Importance and implications of exosomes in nephrology and urology by Mahl, Lina, Ollig, Johanna, Schweihofer, Verena, Wiegand, Lara, Torkler, Phillipp, Haerteis, Silke, Aung, Thiha

“…Exosomes are extracellular vesicles that are formed by two invaginations of the plasma membrane and can be released by all eukaryotic cells. Because of their…”
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Predicting high-grade prostate cancer at initial biopsy: clinical performance of the ExoDx (EPI) Prostate Intelliscore test in three independent prospective studies by Margolis, Erik, Brown, Gordon, Partin, Alan, Carter, Ballentine, McKiernan, James, Tutrone, Ronald, Torkler, Phillipp, Fischer, Christian, Tadigotla, Vasisht, Noerholm, Mikkel, Donovan, Michael J., Skog, Johan

“…Background The ability to discriminate indolent from clinically significant prostate cancer (PC) at the initial biopsy remains a challenge. The ExoDx Prostate…”
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PNFLBA-15 INTERIM RESULTS OF A NOVEL ‘ADAPTIVE’ REGISTRATION-UTILITY TRIAL ASSESSING THE PERFORMANCE OF EXODX® (PROSTATE) INTELLISCORE (EPI); A NON-DRE URINE EXOSOME GENE EXPRESSION ASSAY TO PREDICT HIGH GRADE DISEASE ON INITIAL BIOPSY by Partin, Alan, Torkler, Phillipp, Noerholm, Mikkel, Skog, Johan, Donovan, Michael

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MP33-05 RADICAL PROSTATECTOMY OUTCOMES FROM A VALIDATED URINE EXOSOME GENE EXPRESSION ASSAY WHICH PREDICTS HIGH-GRADE (GS7) PROSTATE CANCER SUGGESTS UTILITY FOR MEN ENROLLED IN ACTIVE SURVEILLANCE by Donovan, Michael, Torkler, Phillipp, Noerholm, Mikkel, Skog, Johan, McKiernan, James

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Performance of a validated urine exosome gene expression assay to predict high-grade prostate cancer utilizing the International Society of Urological Pathology (ISUP) 2014 grading system by Donovan, Michael, Torkler, Phillipp, Skog, Johan, Noerholm, Mikkel, Carroll, Peter

“…Abstract only 49 Background: Overdetection and overtreatment of indolent prostate cancer (PCa) remains a significant health issue requiring noninvasive assays…”
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Urine exosome gene expression assay net benefit analysis in a large pooled cohort by McKiernan, James M., Tutrone, Ronald F., Donovan, Michael Joseph, Torkler, Phillipp, Noerholm, Mikkel, Alter, Jason, Skog, Johan

“…Abstract only 287 Background: Over-diagnosis of indolent prostate cancer (PCa), supports the need for non-invasive tools that can differentiate low-grade (≤…”
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Performance of a clinically validated urine exosome gene expression test to predict high grade prostate cancer in men with a prior negative biopsy by Donovan, Michael Joseph, Torkler, Phillipp, Noerholm, Mikkel, Skog, Johan, McKiernan, James M

“…Abstract only 119 Background: The over-diagnosis of low grade, indolent prostate cancer (PCa) initiates significant patient anxiety regarding treatment options…”
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Performance of a validated urine exosome gene expression test (EPI) in men within the USPSTF suggested age-group of 55 to 69 years at initial biopsy with a PSA 2-10 ng/mL by Donovan, Michael J., Noerholm, Mikkel, Torkler, Phillipp, Skog, Johan, Margolis, Eric, Brown, Gordon Andrew, McKiernan, James M.

“…Abstract only 53 Background: Prostate-specific antigen (PSA) plays a key-role in prostate cancer (PCa) risk stratification but leads to over-diagnosis of low…”
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A Prospective Adaptive Utility Trial to Validate Performance of a Novel Urine Exosome Gene Expression Assay to Predict High-grade Prostate Cancer in Patients with Prostate-specific Antigen 2–10ng/ml at Initial Biopsy by McKiernan, James, Donovan, Michael J., Margolis, Eric, Partin, Alan, Carter, Ballentine, Brown, Gordon, Torkler, Phillipp, Noerholm, Mikkel, Skog, Johan, Shore, Neal, Andriole, Gerry, Thompson, Ian, Carroll, Peter

“…Discriminating indolent from clinically significant prostate cancer (PCa) in the initial biopsy setting remains an important issue. Prospectively evaluated…”
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