Search Results - "Tordo, Julie"

Division-Coupled Astrocytic Differentiation and Age-Related Depletion of Neural Stem Cells in the Adult Hippocampus by Encinas, Juan M., Michurina, Tatyana V., Peunova, Natalia, Park, June-Hee, Tordo, Julie, Peterson, Daniel A., Fishell, Gord, Koulakov, Alex, Enikolopov, Grigori

“…Production of new neurons in the adult hippocampus decreases with age; this decline may underlie age-related cognitive impairment. Here we show that continuous…”
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Inhibition of somatosensory mechanotransduction by annexin A6 by Raouf, Ramin, Lolignier, Stéphane, Sexton, Jane E, Millet, Queensta, Santana-Varela, Sonia, Biller, Anna, Fuller, Alice M, Pereira, Vanessa, Choudhary, Jyoti S, Collins, Mark O, Moss, Stephen E, Lewis, Richard, Tordo, Julie, Henckaerts, Els, Linden, Michael, Wood, John N

“…Mechanically activated, slowly adapting currents in sensory neurons have been linked to noxious mechanosensation. The conotoxin NMB-1 (noxious mechanosensation…”
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The Cellular Processing Capacity Limits the Amounts of Chimeric U7 snRNA Available for Antisense Delivery by Eckenfelder, Agathe, Tordo, Julie, Babbs, Arran, Davies, Kay E, Goyenvalle, Aurélie, Danos, Olivier

“…Many genetic diseases are induced by mutations disturbing the maturation of pre-mRNAs, often affecting splicing. Antisense oligoribonucleotides (AONs) have…”
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A novel adeno-associated virus capsid with enhanced neurotropism corrects a lysosomal transmembrane enzyme deficiency by Tordo, Julie, O'Leary, Claire, Antunes, André S L M, Palomar, Nuria, Aldrin-Kirk, Patrick, Basche, Mark, Bennett, Antonette, D'Souza, Zelpha, Gleitz, Hélène, Godwin, Annie, Holley, Rebecca J, Parker, Helen, Liao, Ai Yin, Rouse, Paul, Youshani, Amir Saam, Dridi, Larbi, Martins, Carla, Levade, Thierry, Stacey, Kevin B, Davis, Daniel M, Dyer, Adam, Clément, Nathalie, Björklund, Tomas, Ali, Robin R, Agbandje-McKenna, Mavis, Rahim, Ahad A, Pshezhetsky, Alexey, Waddington, Simon N, Linden, R Michael, Bigger, Brian W, Henckaerts, Els

“…Tordo et al. present a novel AAV gene therapy vector, AAV-TT, which exceeds the current benchmark neurotropic serotypes AAV9 and AAVrh10 and enables…”
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AAV9 intracerebroventricular gene therapy improves lifespan, locomotor function and pathology in a mouse model of Niemann-Pick type C1 disease by Hughes, Michael P, Smith, Dave A, Morris, Lauren, Fletcher, Claire, Colaco, Alexandria, Huebecker, Mylene, Tordo, Julie, Palomar, Nuria, Massaro, Giulia, Henckaerts, Els, Waddington, Simon N, Platt, Frances M, Rahim, Ahad A

“…Abstract Niemann-Pick type C disease (NP-C) is a fatal neurodegenerative lysosomal storage disorder. It is caused in 95% of cases by a mutation in the NPC1…”
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Comparative structural, biophysical, and receptor binding study of true type and wild type AAV2 by Bennett, Antonette, Hull, Joshua, Jolinon, Nelly, Tordo, Julie, Moss, Katie, Binns, Enswert, Mietzsch, Mario, Hagemann, Cathleen, Linden, R. Michael, Serio, Andrea, Chipman, Paul, Sousa, Duncan, Broecker, Felix, Seeberger, Peter, Henckaerts, Els, McKenna, Robert, Agbandje-McKenna, Mavis

“…[Display omitted] •Structurally, the VP topology and capsid morphology of AAV-TT is homologous to AAV2.•AAV-TT differs by 14 amino acids from AAV2, two of…”
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Gene therapy mediated correction of neurological manifestations of MPS IIIC using a novel AAV serotype by O'Leary, Claire, Antunes, Andre, Tordo, Julie, Liao, Ai Yin, Parker, Helen, Gleitz, Helene, Holley, Rebecca, Youshani, Amir Saam, Dridi, Larbi, Martins, Carla, Pshezhetsky, Alexey, Henckearts, Els, Bigger, Brian

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256. A Novel Rationally Designed AAV Capsid Yields a Potent Neurotropic Gene Therapy Vector by Henckaerts, Els, Tordo, Julie, Palomar, Nuria, Rahman, Jahedur, Aldrin-Kirk, Patrick, Basche, Mark, Bennett, Antonette, O'Leary, Claire, Ali, Robin, Agbandje-McKenna, Mavis, Bigger, Brian, Rahim, Ahad A., Björklund, Tomas, Waddington, Simon, Linden, R. Michael

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