Search Results - "Tor, Yitzhak"

Antibiotics and Bacterial Resistance in the 21st Century by Fair, Richard J., Tor, Yitzhak

“…Dangerous, antibiotic resistant bacteria have been observed with increasing frequency over the past several decades. In this review the factors that have been…”
Get full text

Targeting heparin and heparan sulfate protein interactions by Weiss, Ryan J, Esko, Jeffrey D, Tor, Yitzhak

“…Heparin and heparan sulfate glycosaminoglycans are long, linear polysaccharides that are made up of alternating dissacharide sequences of sulfated uronic acid…”
Get more information

Expanding a fluorescent RNA alphabet: synthesis, photophysics and utility of isothiazole-derived purine nucleoside surrogates by Rovira, Alexander R, Fin, Andrea, Tor, Yitzhak

“…A series of emissive ribonucleoside purine mimics, all comprised of an isothiazolo[4,3- ]pyrimidine core, was prepared using a divergent pathway involving a…”
Get full text

Isomorphic Emissive GTP Surrogate Facilitates Initiation and Elongation of in Vitro Transcription Reactions by McCoy, Lisa S, Shin, Dongwon, Tor, Yitzhak

“…The fastidious behavior of T7 RNA polymerase limits the incorporation of synthetic nucleosides into RNA transcripts, particularly at or near the promoter. The…”
Get full text

Emissive Alkylated Guanine Analogs as Probes for Monitoring O6-Alkylguanine-DNA-transferase Activity by Steinbuch, Kfir B., Bucardo, Marcela, Tor, Yitzhak

“…Human O 6 -alkylguanine-DNA-transferase (hAGT) is a repair protein that provides protection from mutagenic events caused by O 6 -alkylguanine lesions. As this…”
Get full text

Modification of oligodeoxynucleotides by on-column Suzuki cross-coupling reactions by Ejlersen, Maria, Lou, Chenguang, Sanghvi, Yogesh S, Tor, Yitzhak, Wengel, Jesper

“…The on-column functionalization of oligodeoxynucleotides via base-free Suzuki cross-coupling reactions is reported herein. These cross-coupling reactions were…”
Get more information

Conquering 2‑Aminopurine’s Deficiencies: Highly Emissive Isomorphic Guanosine Surrogate Faithfully Monitors Guanosine Conformation and Dynamics in DNA by Sholokh, Marianna, Sharma, Rajhans, Shin, Dongwon, Das, Ranjan, Zaporozhets, Olga A, Tor, Yitzhak, Mély, Yves

“…The archetypical fluorescent nucleoside analog, 2-aminopurine (2Ap), has been used in countless assays, though it suffers from very low quantum yield,…”
Get full text

Visibly Emissive and Responsive Extended 6‑Aza-Uridines by Hopkins, Patrycja A, Sinkeldam, Renatus W, Tor, Yitzhak

“…A family of extended 5-modified-6-aza-uridines was obtained via Suzuki coupling reactions with a common brominated precursor. Extending the…”
Get full text

Genome-wide screens uncover KDM2B as a modifier of protein binding to heparan sulfate by Weiss, Ryan J., Spahn, Philipp N., Chiang, Austin W. T., Liu, Qing, Li, Jing, Hamill, Kristina M., Rother, Sandra, Clausen, Thomas M., Hoeksema, Marten A., Timm, Bryce M., Godula, Kamil, Glass, Christopher K., Tor, Yitzhak, Gordts, Philip L. S. M., Lewis, Nathan E., Esko, Jeffrey D.

“…Heparan sulfate (HS) proteoglycans bind extracellular proteins that participate in cell signaling, attachment and endocytosis. These interactions depend on the…”
Get full text

Author Correction: Genome-wide screens uncover KDM2B as a modifier of protein binding to heparan sulfate by Weiss, Ryan J., Spahn, Philipp N., Chiang, Austin W. T., Liu, Qing, Li, Jing, Hamill, Kristina M., Rother, Sandra, Clausen, Thomas M., Hoeksema, Marten A., Timm, Bryce M., Godula, Kamil, Glass, Christopher K., Tor, Yitzhak, Gordts, Philip L. S. M., Lewis, Nathan E., Esko, Jeffrey D.

Get full text

Cellular uptake of modified aminoglycosides by Hadidi, Kaivin, Wexselblatt, Ezequiel, Esko, Jeffrey D, Tor, Yitzhak

“…The uptake of modified amino- and guanidino-glycosides derived from kanamycin, tobramycin and neomycin in native and mutant CHO cells is examined using…”
Get full text

Cellular activity of siRNA oligonucleotides containing synthetic isomorphic nucleoside surrogates by Shin, Dongwon, Lönn, Peter, Dowdy, Steven F, Tor, Yitzhak

“…Singly and multiply modified synthetic siRNA oligonucleotides, containing isomorphic surrogate nucleobases, show high interference potency in cell culture,…”
Get more information

Enzymatic incorporation and utilization of an emissive 6-azauridine by Hopkins, Patrycja A, McCoy, Lisa S, Tor, Yitzhak

“…To display favorable fluorescent properties, the non-emissive native nucleosides need to be modified. Here we present a motif that relies on conjugating…”
Get more information

Surfen, a small molecule antagonist of heparan sulfate by Schuksz, Manuela, Fuster, Mark M, Brown, Jillian R, Crawford, Brett E, Ditto, David P, Lawrence, Roger, Glass, Charles A, Wang, Lianchun, Tor, Yitzhak, Esko, Jeffrey D

“…In a search for small molecule antagonists of heparan sulfate, we examined the activity of bis-2-methyl-4-amino-quinolyl-6-carbamide, also known as surfen…”
Get full text

Design, Synthesis, and Spectroscopic Properties of Extended and Fused Pyrrolo-dC and Pyrrolo-C Analogs by Noé, Mary S, Ríos, Andro C, Tor, Yitzhak

“…The syntheses of four fluorescent nucleoside analogs, related to pyrrolo-C (PyC) and pyrrolo-dC (PydC) through the conjugation or fusion of a thiophene moiety,…”
Get full text

Isomorphic Fluorescent Nucleosides by Tor, Yitzhak

“…Conspectus In 1960, Weber prophesied that “There are many ways in which the properties of the excited state can be utilized to study points of ignorance of the…”
Get full text

Enzymatic Incorporation of Emissive Pyrimidine Ribonucleotides by Srivatsan, Seergazhi G., Tor, Yitzhak

“…Making an emission: T7 RNA polymerase incorporates a series of thiophene‐modified uridine triphosphate (UTP) analogues to generate emissive RNA transcripts…”
Get full text

Modified 6-Aza Uridines: Highly Emissive pH-Sensitive Fluorescent Nucleosides by Sinkeldam, Renatus W., Hopkins, Patrycja A., Tor, Yitzhak

“…Optimized facile syntheses and highly desirable spectroscopic properties of two isomorphic fluorescent pyrimidines, comprising a 1,2,4‐triazine motif…”
Get full text

Small molecule antagonists of cell-surface heparan sulfate and heparin-protein interactions by Weiss, Ryan J, Gordts, Philip L S M, Le, Dzung, Xu, Ding, Esko, Jeffrey D, Tor, Yitzhak

“…Surfen, bis-2-methyl-4-amino-quinolyl-6-carbamide, was previously reported as a small molecule antagonist of heparan sulfate (HS), a key cell-surface…”
Get full text

Stringent Nucleotide Recognition by the Ribosome at the Middle Codon Position by Liu, Wei, Shin, Dongwon, Ng, Martin, Sanbonmatsu, Karissa Y, Tor, Yitzhak, Cooperman, Barry S

“…Accurate translation of the genetic code depends on mRNA:tRNA codon:anticodon base pairing. Here we exploit an emissive, isosteric adenosine surrogate that…”
Get full text