Search Results - "Toppet, Suzanne M."

Stereoselective transformation of pyrazinones into substituted analogues of cis-5-amino-6-oxo-2-piperidinemethanol and cis-5-amino-2-piperidinemethanol by Rogiers, Joeri, De Borggraeve, Wim M, Toppet, Suzanne M, Compernolle, Frans, Hoornaert, Georges J

“…Various analogues of cis-5-amino-6-oxo-2-piperidinemethanol and cis-5-amino-2-piperidinemethanol have been prepared via Diels–Alder reaction of substituted…”
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Synthesis of a conformationally restricted dipeptide analogue and its evaluation as a β-turn mimic by De Borggraeve, Wim M, Rombouts, Frederik J.R, Van der Eycken, Erik V, Toppet, Suzanne M, Hoornaert, Georges J

“…Dichloropyrazinone 3 was converted into a conformationally restricted dipeptide analogue 8 by means of a Diels–Alder strategy. The β-turn characteristics of…”
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Development of a Functionalizable External β-Turn Mimic Based on a cis-Fused 1,7-Naphthyridine Scaffold by Rombouts, Frederik J. R., Borggraeve, Wim M. De, Delaere, David, Froeyen, Matheus, Toppet, Suzanne M., Compernolle, Frans, Hoornaert, Georges J.

“…An intramolecular Diels−Alder strategy using 2(1H)‐pyrazinones was applied to generate a substituted perhydro‐1,7‐naphthyridine ring system that served as a…”
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Synthesis and conformational analysis of Substance P antagonist analogues based on a 1,7-naphthyridine scaffold by Rombouts, Frederik J.R, Van den Bossche, Jeroen, Toppet, Suzanne M, Compernolle, Frans, Hoornaert, Georges J

“…Two analogues of formerly described piperidine-based Substance P antagonists have been synthesised using an intramolecular Diels–Alder reaction of…”
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Intramolecular Diels–Alder reactions of N-alkenyl-2(1 H)-pyrazinones: generation of a novel type of cis-1,7-naphthyridine by Rombouts, Frederik J.R, De Borggraeve, Wim, Toppet, Suzanne M, Compernolle, Frans, Hoornaert, Georges J

“…The intramolecular Diels–Alder reaction of three 1-(ω-alkenyl)-2(1 H)-pyrazinones was investigated. Cycloaddition was shown to proceed for 1-(4-pentenyl)- and…”
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Diels–Alder reactions with pyridine o-quinodimethanes generated from pyridine sulfolenes by Cappelle, Steven L, Vogels, Ilse A, Govaerts, Tom C, Toppet, Suzanne M, Compernolle, Frans, Hoornaert, Georges J

“…An efficient route has been developed for the synthesis of polysubstituted 6,6-dioxo-6,7-dihydrothieno[3,4- b]pyridines 3 , which serve as excellent precursors…”
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Cycloaddition of 3-Amino-5-chloro-2(1H)-pyrazinones and Olefins:  Ring Transformation into 3-Amino- or 6-Cyano-Substituted 2-Pyridinone Systems by Vandenberghe, Stef M, Buysens, Kris J, Meerpoel, Lieven, Loosen, Patrick K, Toppet, Suzanne M, Hoornaert, Georges J

“…The cycloadducts formed from the Diels−Alder reaction of 3-amino-5-chloro-2(1H)-pyrazinones with methyl acrylate in toluene are subject to two alternative…”
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Thermolysis of benzopyranone-indenone adducts: a new route to the C-nor-D-homo steroid skeleton by Vanderzande, Dirk J, Ceustermans, Roger A, Martens, Henri J, Toppet, Suzanne M, Hoornaert, Georges J

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Intramolecular Diels-Alder reactions of 2(1 H)-pyrazinones: Synthesis of new Furo/Pyrano-pyridinones and -pyridines by J. Buysens, Kris, M. Vandenberghe, Didier, M. Toppet, Suzanne, J. Hoornaert, Georges

“…2(1 H)-Pyrazinones 2–5 with in 3-position either a 3- or 4-alkynyloxy side chain and 2(1 H)-pyrazinones 9–10 carrying the corresponding 2- or…”
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A versatile stereospecific synthesis of the 1,3-disubstituted benzo[ a]quinolizidine framework via 2-aryl substituted pyridines by Van der Eycken, Erik, Deroover, Geert, Toppet, Suzanne M., Hoornaert, Georges J.

“…The stereospecific synthesis of the 1,3-disubstituted benzo[ a]quinolizidine 6 is described starting from the easily accessible 3-arylated-6-substituted…”
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Generation of polysubstituted 2-pyridinecarboxylic acid derivatives from the reaction of (functionalised) 2-oxa-5-azabicyclo[2.2.2]oct-5-en-3-ones with various nucleophiles by Dubois, Kristof J., Fannes, Christine C., Toppet, Suzanne M., Hoornaert, Georges J.

“…By selective reaction of the chlorimine function in the adducts 2 from 3,5-dichloro-2 H-1,4-oxazin-2-ones and double bond systems, a series of 6-substituted…”
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