Search Results - "Toppala, Sini"

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    Association of Midlife Inflammatory Markers With Cognitive Performance at 10-Year Follow-up by Kipinoinen, Teemu, Toppala, Sini, Rinne, Juha O., Viitanen, Matti H., Jula, Antti M., Ekblad, Laura L.

    Published in Neurology (15-11-2022)
    “…Chronic low-grade inflammation, commonly associated with cardiovascular diseases and risk factors, has been associated inconclusively with cognitive decline…”
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    Journal Article
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    Chronic low‐grade inflammation predicts greater decline in verbal fluency and word‐list learning on 10 years' follow‐up by Kipinoinen, Teemu, Toppala, Sini, Viitanen, Matti, Rinne, Juha O., Jula, Antti, Ekblad, Laura L.

    Published in Alzheimer's & dementia (01-12-2021)
    “…Background Processes leading to the clinical presentation of Alzheimer´s disease (AD) start to develop years or even decades beforehand. Chronic low‐grade…”
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    Journal Article
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    Association of Early β-Amyloid Accumulation and Neuroinflammation Measured With [11C]PBR28 in Elderly Individuals Without Dementia by Toppala, Sini, Ekblad, Laura L., Tuisku, Jouni, Helin, Semi, Johansson, Jarkko J., Laine, Hanna, Löyttyniemi, Eliisa, Marjamäki, Päivi, Blennow, Kaj, Zetterberg, Henrik, Jula, Antti, Viitanen, Matti, Rinne, Juha O.

    Published in Neurology (23-03-2021)
    “…To examine whether early β-amyloid (Aβ) accumulation and metabolic risk factors are associated with neuroinflammation in elderly individuals without dementia…”
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    Midlife insulin resistance, APOE genotype, and change in late‐life brain amyloid accumulation – a 5‐year follow‐up 11C‐PIB‐PET study by Pietilä, Elina M., Ekblad, Laura L., Snellman, Anniina, Toppala, Sini, Tuisku, Jouni, Helin, Semi, Viitanen, Matti, Jula, Antti, Rinne, Juha O.

    Published in Alzheimer's & dementia (01-06-2023)
    “…Background Midlife insulin resistance has been associated with an increased risk for cognitive decline (1) and amyloid accumulation (2). We hypothesized that…”
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    Midlife insulin resistance, APOE genotype, and change in late‐life brain amyloid accumulation – a 5‐year follow‐up 11 C‐PIB‐PET study by Pietilä, Elina M., Ekblad, Laura L., Snellman, Anniina, Toppala, Sini, Tuisku, Jouni, Helin, Semi, Viitanen, Matti, Jula, Antti, Rinne, Juha O.

    Published in Alzheimer's & dementia (01-06-2023)
    “…Abstract Background Midlife insulin resistance has been associated with an increased risk for cognitive decline (1) and amyloid accumulation (2). We…”
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    Journal Article
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    Oral Glucose Tolerance Test Predicts Episodic Memory Decline: A 10-Year Population-Based Follow-up Study by Toppala, Sini, Ekblad, Laura L, Viitanen, Matti, Rinne, Juha O, Jula, Antti

    Published in Diabetes care (01-10-2021)
    “…To examine if the 2-h value of an oral glucose tolerance test (OGTT) can predict cognitive decline. This study is based on a subpopulation of the Finnish…”
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    Impaired Early Insulin Response to Glucose Load Predicts Episodic Memory Decline: A 10-Year Population-Based Cohort Follow-Up of 45-74-Year-Old Men and Women by Toppala, Sini, Ekblad, Laura L, Viitanen, Matti, Rinne, Juha O, Jula, Antti

    Published in Journal of Alzheimer's disease (01-01-2023)
    “…Diabetes increases the risk for cognitive decline, but the mechanisms behind this association remain unknown. Impaired early insulin secretion in elderly men…”
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    Albuminuria and Microalbuminuria as Predictors of Cognitive Performance in a General Population: An 11-Year Follow-Up Study by Ekblad, Laura L, Toppala, Sini, Johansson, Jouni K, Koskinen, Seppo, Sundvall, Jouko, Rinne, Juha O, Puukka, Pauli, Viitanen, Matti, Jula, Antti

    Published in Journal of Alzheimer's disease (01-01-2018)
    “…Microalbuminuria, defined as urine albumin-to-creatinine ratio (UACR)>3.0 mg/mmol and ≤ 30 mg/mmol, is an early marker of endothelial damage of the renal…”
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