MULTICHANNEL INTRALUMINAL IMPEDANCE-PH MEASUREMENT AND ITS OPPORTUNITIES IN CHILDREN WITH GASTROESOPHAGEAL REFLUX DISEASE

Aim: To review data from clinical studies on a multichannel intraluminal impedance-pH measurement in children with gastroesophageal reflux disease (GERD). Key points: Esophageal pH measurement is considered a golden standard of GERD diagnostics in children. However, this method can identify on...

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Bibliographic Details
Published in:	Alʹmanakh klinicheskoĭ medit͡s︡iny no. 42; pp. 12 - 22
Main Authors:	Erdes, S. I., Polishchuk, A. R., Topolskova, I. A.
Format:	Journal Article
Language:	English Russian
Published:	MONIKI 12-02-2016
Subjects:	children diagnostics esophagitis gastroesophageal reflux disease infant multichannel impedance measurement of the esophagus
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Summary:	Aim: To review data from clinical studies on a multichannel intraluminal impedance-pH measurement in children with gastroesophageal reflux disease (GERD). Key points: Esophageal pH measurement is considered a golden standard of GERD diagnostics in children. However, this method can identify only the acid reflux. Recently, multichannel intraluminal impedance measurement of esophagus has been introduced into the work-up of such children. This method gives the opportunity to diagnose liquid, gas or mixed types of reflux and to determine whether it is acid, weakly acid or basic, as well as to obtain data on localization of the bolus in the esophagus, its length and direction of movement (antegrade or retrograde). We present the information on normal parameters of multichannel intraluminal impedance and its use for assessment of infants, as well as on changes in its parameters in children with apnoe and on clinical value of non-acid reflux. The significance of multichannel intraluminal impedance in detection of esophageal disorders in patients with otolaryngologic symptoms and other extra-esophageal signs is discussed. Аn association between the results of this method and endoscopic and histological abnormalities found in GERD patients is being actively studied. The authors of the review focus their attention on the data on changes of multichannel intraluminal impedance parameters during treatment of GERD children with proton pump inhibitors. Conclusion: Multichannel intraluminal impedance is a new modern method with wide spectrum of diagnostic opportunities.
ISSN:	2072-0505 2587-9294
DOI:	10.18786/2072-0505-2015-42-12-22