Search Results - "Topless, Ruth K"

Evaluation of the diet wide contribution to serum urate levels: meta-analysis of population based cohorts by Major, Tanya J, Topless, Ruth K, Dalbeth, Nicola, Merriman, Tony R

“…AbstractObjectiveTo systematically test dietary components for association with serum urate levels and to evaluate the relative contributions of estimates of…”
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The comparative effect of exposure to various risk factors on the risk of hyperuricaemia: diet has a weak causal effect by Topless, Ruth K G, Major, Tanya J, Florez, Jose C, Hirschhorn, Joel N, Cadzow, Murray, Dalbeth, Nicola, Stamp, Lisa K, Wilcox, Philip L, Reynolds, Richard J, Cole, Joanne B, Merriman, Tony R

“…Prevention of hyperuricaemia (HU) is critical to the prevention of gout. Understanding causal relationships and relative contributions of various risk factors…”
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Interaction of genetic variation at ADH1B and MLXIPL with alcohol consumption for elevated serum urate level and gout among people of European ethnicity by Chuah, Min H, Leask, Megan P, Topless, Ruth K, Gamble, Gregory D, Sumpter, Nicholas A, Stamp, Lisa K, Merriman, Tony R, Dalbeth, Nicola

“…Alcohol consumption is a risk factor for hyperuricaemia and gout. Multiple single-nucleotide polymorphisms (SNPs) have been identified as associated with both…”
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Pleiotropic effect of the ABCG2 gene in gout: involvement in serum urate levels and progression from hyperuricemia to gout by Wrigley, Rebekah, Phipps-Green, Amanda J, Topless, Ruth K, Major, Tanya J, Cadzow, Murray, Riches, Philip, Tausche, Anne-Kathrin, Janssen, Matthijs, Joosten, Leo A B, Jansen, Tim L, So, Alexander, Harré Hindmarsh, Jennie, Stamp, Lisa K, Dalbeth, Nicola, Merriman, Tony R

“…The ABCG2 Q141K (rs2231142) and rs10011796 variants associate with hyperuricaemia (HU). The effect size of ABCG2 rs2231142 on urate is ~ 60% that of SLC2A9,…”
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Gout, Rheumatoid Arthritis, and the Risk of Death Related to Coronavirus Disease 2019: An Analysis of the UK Biobank by Topless, Ruth K., Phipps‐Green, Amanda, Leask, Megan, Dalbeth, Nicola, Stamp, Lisa K., Robinson, Philip C., Merriman, Tony R.

“…Objectives The objectives for this study were to assess whether gout and/or rheumatoid arthritis (RA) are risk factors for coronavirus disease 2019 (COVID‐19)…”
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Mid-pass whole genome sequencing enables biomedical genetic studies of diverse populations by Emde, Anne-Katrin, Phipps-Green, Amanda, Cadzow, Murray, Gallagher, C Scott, Major, Tanya J, Merriman, Marilyn E, Topless, Ruth K, Takei, Riku, Dalbeth, Nicola, Murphy, Rinki, Stamp, Lisa K, de Zoysa, Janak, Wilcox, Philip L, Fox, Keolu, Wasik, Kaja A, Merriman, Tony R, Castel, Stephane E

“…Historically, geneticists have relied on genotyping arrays and imputation to study human genetic variation. However, an underrepresentation of diverse…”
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The Toll-Like Receptor 4 (TLR4) Variant rs2149356 and Risk of Gout in European and Polynesian Sample Sets by Rasheed, Humaira, McKinney, Cushla, Stamp, Lisa K, Dalbeth, Nicola, Topless, Ruth K, Day, Richard, Kannangara, Diluk, Williams, Kenneth, Smith, Malcolm, Janssen, Matthijs, Jansen, Tim L, Joosten, Leo A, Radstake, Timothy R, Riches, Philip L, Tausche, Anne-Kathrin, Lioté, Frederic, Lu, Leo, Stahl, Eli A, Choi, Hyon K, So, Alexander, Merriman, Tony R

“…Deposition of crystallized monosodium urate (MSU) in joints as a result of hyperuricemia is a central risk factor for gout. However other factors must exist…”
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Association study involving polymorphisms in IL-6, IL-1RA, and CTLA4 genes and rheumatic heart disease in New Zealand population of Māori and Pacific ancestry by Azevedo, Pedro M., Merriman, Tony R., Topless, Ruth K., Wilson, Nigel J., Crengle, Sue, Lennon, Diana R.

“…•RF incidence is among the world’s highest amid NZ individuals of Polynesian ancestry.•We found IL-6 promoter rs1800797 might influence susceptibility for RHD…”
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Genetic Polymorphisms on OPRM1, DRD2, DRD4 , and COMT in Young Adults: Lack of Association With Alcohol Consumption by Chung, Patrick, Logge, Warren B, Riordan, Benjamin C, Haber, Paul S, Merriman, Marilyn E, Phipps-Green, Amanda, Topless, Ruth K, Merriman, Tony R, Conner, Tamlin, Morley, Kirsten C

“…Risk behaviors for young adults such as alcohol use are associated with increased risk of morbidity and mortality. Patterns of risk behavior may be genetically…”
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The Oxytocin Receptor Gene ( OXTR ) Variant rs53576 Is Not Related to Emotional Traits or States in Young Adults by Conner, Tamlin S, McFarlane, Karma G, Choukri, Maria, Riordan, Benjamin C, Flett, Jayde A M, Phipps-Green, Amanda J, Topless, Ruth K, Merriman, Marilyn E, Merriman, Tony R

“…To understand the genetic underpinnings of emotion, researchers have studied genetic variants in the oxytocin system, a hormone and neurotransmitter important…”
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Association of rare and common genetic variants in MOCOS with inadequate response to allopurinol by Fanning, Niamh C, Cadzow, Murray, Topless, Ruth K, Frampton, Chris, Dalbeth, Nicola, Merriman, Tony R, Stamp, Lisa K

“…The minor allele of the common rs2231142 ABCG2 variant predicts inadequate response to allopurinol urate lowering therapy. We hypothesize that additional…”
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Correspondence on 'Variants in urate transporters, ADH1B , GCKR and MEPE genes associated with transition from asymptomatic hyperuricaemia to gout: results of the first gout versus asymptomatic hyperuricaemia GWAS in Caucasians using data from the UK Biobank' by Takei, Riku, Sumpter, Nicholas A, Phipps-Green, Amanda, Cadzow, Murray, Topless, Ruth K, Reynolds, Richard J, Merriman, Tony R

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Factors associated with orthodontic pain by Lin, Wei, Farella, Mauro, Antoun, Joseph S., Topless, Ruth K., Merriman, Tony R., Michelotti, Ambra

“…Background Pain experienced at teeth during orthodontic treatment varies largely over time, with the reasons for its interindividual variability being largely…”
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Population‐Specific Resequencing Associates the ATP‐Binding Cassette Subfamily C Member 4 Gene With Gout in New Zealand Māori and Pacific Men by Tanner, Callum, Boocock, James, Stahl, Eli A., Dobbyn, Amanda, Mandal, Asim K., Cadzow, Murray, Phipps‐Green, Amanda J., Topless, Ruth K., Hindmarsh, Jennie Harré, Stamp, Lisa K., Dalbeth, Nicola, Choi, Hyon K., Mount, David B., Merriman, Tony R.

“…Objective There is no evidence for a genetic association between organic anion transporters 1–3 (SLC22A6, SLC22A7, and SLC22A8) and multidrug resistance…”
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Aotearoa New Zealand Māori and Pacific Population-amplified Gout Risk Variants: CLNK Is a Separate Risk Gene at the SLC2A9 Locus by Ji, Aichang, Shaukat, Amara, Takei, Riku, Bixley, Matthew, Cadzow, Murray, Topless, Ruth K., Major, Tanya J., Phipps-Green, Amanda, Merriman, Marilyn E., Hindmarsh, Jennie Harré, Stamp, Lisa K., Dalbeth, Nicola, Li, Changgui, Merriman, Tony R.

“…Objective The Māori and Pacific (Polynesian) population of Aotearoa New Zealand has a high prevalence of gout. Our aim was to identify potentially functional…”
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Publisher Correction: A genome-wide association analysis reveals new pathogenic pathways in gout by Major, Tanya J., Takei, Riku, Matsuo, Hirotaka, Leask, Megan P., Sumpter, Nicholas A., Topless, Ruth K., Shirai, Yuya, Wang, Wei, Cadzow, Murray J., Phipps-Green, Amanda J., Li, Zhiqiang, Ji, Aichang, Merriman, Marilyn E., Morice, Emily, Kelley, Eric E., Wei, Wen-Hua, McCormick, Sally P. A., Bixley, Matthew J., Reynolds, Richard J., Saag, Kenneth G., Fadason, Tayaza, Golovina, Evgenia, O’Sullivan, Justin M., Stamp, Lisa K., Dalbeth, Nicola, Abhishek, Abhishek, Doherty, Michael, Roddy, Edward, Jacobsson, Lennart T. H., Kapetanovic, Meliha C., Melander, Olle, Andrés, Mariano, Pérez-Ruiz, Fernando, Torres, Rosa J., Radstake, Timothy, Jansen, Timothy L., Janssen, Matthijs, Joosten, Leo A. B., Liu, Ruiqi, Gaal, Orsolya I., Crişan, Tania O., Rednic, Simona, Kurreeman, Fina, Huizinga, Tom W. J., Toes, René, Lioté, Frédéric, Richette, Pascal, Bardin, Thomas, Ea, Hang Korng, Pascart, Tristan, McCarthy, Geraldine M., Helbert, Laura, Stibůrková, Blanka, Tausche, Anne-K., Uhlig, Till, Vitart, Véronique, Boutin, Thibaud S., Hayward, Caroline, Riches, Philip L., Ralston, Stuart H., Campbell, Archie, MacDonald, Thomas M., Nakayama, Akiyoshi, Takada, Tappei, Nakatochi, Masahiro, Shimizu, Seiko, Kawamura, Yusuke, Toyoda, Yu, Nakaoka, Hirofumi, Yamamoto, Ken, Matsuo, Keitaro, Shinomiya, Nariyoshi, Ichida, Kimiyoshi, Lee, Chaeyoung, Bradbury, Linda A., Brown, Matthew A., Robinson, Philip C., Buchanan, Russell R. C., Hill, Catherine L., Lester, Susan, Smith, Malcolm D., Rischmueller, Maureen, Choi, Hyon K., Stahl, Eli A., Miner, Jeff N., Solomon, Daniel H., Cui, Jing, Giacomini, Kathleen M., Brackman, Deanna J., Jorgenson, Eric M., Liu, Hongbo, Susztak, Katalin, Shringarpure, Suyash, So, Alexander, Okada, Yukinori, Li, Changgui, Shi, Yongyong, Merriman, Tony R.

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A genome-wide association analysis reveals new pathogenic pathways in gout by Major, Tanya J., Takei, Riku, Matsuo, Hirotaka, Leask, Megan P., Sumpter, Nicholas A., Topless, Ruth K., Shirai, Yuya, Wang, Wei, Cadzow, Murray J., Phipps-Green, Amanda J., Li, Zhiqiang, Ji, Aichang, Merriman, Marilyn E., Morice, Emily, Kelley, Eric E., Wei, Wen-Hua, McCormick, Sally P. A., Bixley, Matthew J., Reynolds, Richard J., Saag, Kenneth G., Fadason, Tayaza, Golovina, Evgenia, O’Sullivan, Justin M., Stamp, Lisa K., Dalbeth, Nicola, Abhishek, Abhishek, Doherty, Michael, Roddy, Edward, Jacobsson, Lennart T. H., Kapetanovic, Meliha C., Melander, Olle, Andrés, Mariano, Pérez-Ruiz, Fernando, Torres, Rosa J., Radstake, Timothy, Jansen, Timothy L., Janssen, Matthijs, Joosten, Leo A. B., Liu, Ruiqi, Gaal, Orsolya I., Crişan, Tania O., Rednic, Simona, Kurreeman, Fina, Huizinga, Tom W. J., Toes, René, Lioté, Frédéric, Richette, Pascal, Bardin, Thomas, Ea, Hang Korng, Pascart, Tristan, McCarthy, Geraldine M., Helbert, Laura, Stibůrková, Blanka, Tausche, Anne-K., Uhlig, Till, Vitart, Véronique, Boutin, Thibaud S., Hayward, Caroline, Riches, Philip L., Ralston, Stuart H., Campbell, Archie, MacDonald, Thomas M., Nakayama, Akiyoshi, Takada, Tappei, Nakatochi, Masahiro, Shimizu, Seiko, Kawamura, Yusuke, Toyoda, Yu, Nakaoka, Hirofumi, Yamamoto, Ken, Matsuo, Keitaro, Shinomiya, Nariyoshi, Ichida, Kimiyoshi, Lee, Chaeyoung, Bradbury, Linda A., Brown, Matthew A., Robinson, Philip C., Buchanan, Russell R. C., Hill, Catherine L., Lester, Susan, Smith, Malcolm D., Rischmueller, Maureen, Choi, Hyon K., Stahl, Eli A., Miner, Jeff N., Solomon, Daniel H., Cui, Jing, Giacomini, Kathleen M., Brackman, Deanna J., Jorgenson, Eric M., Liu, Hongbo, Susztak, Katalin, Shringarpure, Suyash, So, Alexander, Okada, Yukinori, Li, Changgui, Shi, Yongyong, Merriman, Tony R.

“…Gout is a chronic disease that is caused by an innate immune response to deposited monosodium urate crystals in the setting of hyperuricemia. Here, we provide…”
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Discordant association of the CREBRF rs373863828 A allele with increased BMI and protection from type 2 diabetes in Māori and Pacific (Polynesian) people living in Aotearoa/New Zealand by Krishnan, Mohanraj, Major, Tanya J., Topless, Ruth K., Dewes, Ofa, Yu, Lennex, Thompson, John M. D., McCowan, Lesley, de Zoysa, Janak, Stamp, Lisa K., Dalbeth, Nicola, Harré Hindmarsh, Jennie, Rapana, Nuku, Deka, Ranjan, Eng, Winston W. H., Weeks, Daniel E., Minster, Ryan L., McGarvey, Stephen T., Viali, Satupa’itea, Naseri, Take, Sefuiva Reupena, Muagututi’a, Wilcox, Phillip, Grattan, David, Shepherd, Peter R., Shelling, Andrew N., Murphy, Rinki, Merriman, Tony R.

“…Aims/hypothesis The A (minor) allele of CREBRF rs373863828 has been associated with increased BMI and reduced risk of type 2 diabetes in the Samoan populations…”
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Association of Gout Polygenic Risk Score With Age at Disease Onset and Tophaceous Disease in European and Polynesian Men With Gout by Sumpter, Nicholas A., Takei, Riku, Cadzow, Murray, Topless, Ruth K. G., Phipps‐Green, Amanda J., Murphy, Rinki, Zoysa, Janak, Watson, Huti, Qasim, Muhammad, Lupi, Alexa S., Abhishek, Abhishek, Andrés, Mariano, Crișan, Tania O., Doherty, Michael, Jacobsson, Lennart, Janssen, Matthijs, Jansen, Tim L., Joosten, Leo A. B., Kapetanovic, Meliha, Lioté, Frédéric, Matsuo, Hirotaka, McCarthy, Geraldine M., Perez‐Ruiz, Fernando, Riches, Philip, Richette, Pascal, Roddy, Edward, Stiburkova, Blanka, So, Alexander, Tausche, Anne‐Kathrin, Torres, Rosa J., Uhlig, Till, Major, Tanya J., Stamp, Lisa K., Dalbeth, Nicola, Choi, Hyon K., Vazquez, Ana I., Leask, Megan P., Reynolds, Richard J., Merriman, Tony R.

“…Objective To determine whether a gout polygenic risk score (PRS) is associated with age at gout onset and tophaceous disease in European, East Polynesian, and…”
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Multiplicative interaction of functional inflammasome genetic variants in determining the risk of gout by McKinney, Cushla, Stamp, Lisa K, Dalbeth, Nicola, Topless, Ruth K, Day, Richard O, Kannangara, Diluk Rw, Williams, Kenneth M, Janssen, Matthijs, Jansen, Timothy L, Joosten, Leo A, Radstake, Timothy R, Riches, Philip L, Tausche, Anne-Kathrin, Lioté, Frederic, So, Alexander, Merriman, Tony R

“…The acute gout flare results from a localised self-limiting innate immune response to monosodium urate (MSU) crystals deposited in joints in hyperuricaemic…”
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