Search Results - "Topilina, Natalya I"

SufB intein of Mycobacterium tuberculosis as a sensor for oxidative and nitrosative stresses by Topilina, Natalya I, Green, Cathleen M, Jayachandran, Pradeepa, Kelley, Danielle S, Stanger, Matthew J, Piazza, Carol Lyn, Nayak, Sasmita, Belfort, Marlene

“…Inteins are mobile genetic elements that self-splice at the protein level. Mycobacteria have inteins inserted into several important genes, including those…”
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Electronic Structure of Neighboring Extein Residue Modulates Intein C-Terminal Cleavage Activity by Shemella, Philip T., Topilina, Natalya I., Soga, Ikko, Pereira, Brian, Belfort, Georges, Belfort, Marlene, Nayak, Saroj K.

“…Protein splicing is an autocatalytic reaction where an intervening element (intein) is excised and the remaining two flanking sequences (exteins) are joined…”
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Post-translational environmental switch of RadA activity by extein-intein interactions in protein splicing by Topilina, Natalya I, Novikova, Olga, Stanger, Matthew, Banavali, Nilesh K, Belfort, Marlene

“…Post-translational control based on an environmentally sensitive intervening intein sequence is described. Inteins are invasive genetic elements that…”
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Intein Clustering Suggests Functional Importance in Different Domains of Life by Novikova, Olga, Jayachandran, Pradeepa, Kelley, Danielle S, Morton, Zachary, Merwin, Samantha, Topilina, Natalya I, Belfort, Marlene

“…Inteins, also called protein introns, are self-splicing mobile elements found in all domains of life. A bioinformatic survey of genomic data highlights a…”
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Recent advances in in vivo applications of intein-mediated protein splicing by Topilina, Natalya I, Mills, Kenneth V

“…Intein-mediated protein splicing has become an essential tool in modern biotechnology. Fundamental progress in the structure and catalytic strategies of cis-…”
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Structure of catalytically competent intein caught in a redox trap with functional and evolutionary implications by Callahan, Brian P, Topilina, Natalya I, Stanger, Matthew J, Van Roey, Patrick, Belfort, Marlene

“…An intein controlled by redox in bacteria is created by engineering a disulfide bond between the catalytic cysteine residue and the flanking polypeptide. A…”
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Chimera-Induced Folding: Implications for Amyloidosis by Takor, Gaius A, Higashiya, Seiichiro, Sorci, Mirco, Topilina, Natalya I, Belfort, Georges, Welch, John T

“…The discoveries that non-native proteins have a role in amyloidosis and that multiple protein misfolding diseases can occur concurrently suggest that…”
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Fibrillation Mechanism of a Model Intrinsically Disordered Protein Revealed by 2D Correlation Deep UV Resonance Raman Spectroscopy by Sikirzhytski, Vitali, Topilina, Natalya I., Takor, Gaius A., Higashiya, Seiichiro, Welch, John T., Uversky, Vladimir N., Lednev, Igor K.

“…Understanding of numerous biological functions of intrinsically disordered proteins (IDPs) is of significant interest to modern life science research. A large…”
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Genetic Engineering Combined with Deep UV Resonance Raman Spectroscopy for Structural Characterization of Amyloid-like Fibrils by Sikirzhytski, Vitali, Topilina, Natalya I, Higashiya, Seiichiro, Welch, John T, Lednev, Igor K

“…Elucidating the structure of the cross-β core in large amyloid fibrils is a challenging problem in modern structural biology. For the first time, a set of de…”
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Charge Distribution and Amyloid Fibril Formation: Insights from Genetically Engineered Model Systems by Topilina, Natalya I, Sikirzhytsky, Vitali, Higashiya, Seiichiro, Ermolenkov, Vladimir V, Lednev, Igor K, Welch, John T

“…The influence of electrostatic interactions on protein amyloidogenesis has been investigated using de novo designed repetitive polypeptides YEHK21…”
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Design and Preparation of β-Sheet Forming Repetitive and Block-Copolymerized Polypeptides by Higashiya, Seiichiro, Topilina, Natalya I, Ngo, Silvana C, Zagorevskii, Dmitri, Welch, John T

“…The design and rapid construction of libraries of genes coding β-sheet forming repetitive and block-copolymerized polypeptides bearing various C- and…”
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A de novo designed 11 kDa polypeptide: Model for amyloidogenic intrinsically disordered proteins by Topilina, Natalya I., Ermolenkov, Vladimir V., Sikirzhytski, Vitali, Higashiya, Seiichiro, Lednev, Igor K., Welch, John T.

“…A de novo polypeptide GH6[(GA)3GY(GA)3GE]8GAH6 (YE8) has a significant number of identical weakly interacting β‐strands with the turns and termini…”
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Reversible Thermal Denaturation of a 60-kDa Genetically Engineered β-Sheet Polypeptide by Lednev, Igor K., Ermolenkov, Vladimir V., Higashiya, Seiichiro, Popova, Ludmila A., Topilina, Natalya I., Welch, John T.

“…A de novo 687-amino-acid residue polypeptide with a regular 32-amino-acid repeat sequence, (GA) 3GY(GA) 3GE(GA) 3GH(GA) 3GK, forms large β-sheet assemblages…”
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β-sheet folding of 11-kDa fibrillogenic polypeptide is completely aggregation driven by Topilina, Natalya I., Ermolenkov, Vladimir V., Higashiya, Seiichiro, Welch, John T., Lednev, Igor K.

“…A de novo polypeptide GH6[(GA)3GY(GA)3GE]8GAH6 (YE8) was designed and genetically engineered to form antiparallel β‐strands of GAGAGA repeats. Modulation of pH…”
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Bilayer Fibril Formation by Genetically Engineered Polypeptides:  Preparation and Characterization by Topilina, Natalya I, Higashiya, Seiichiro, Rana, Narender, Ermolenkov, Vladimir V, Kossow, Christopher, Carlsen, Autumn, Ngo, Silvana C, Wells, Christopher C, Eisenbraun, Eric T, Dunn, Kathleen A, Lednev, Igor K, Geer, Robert E, Kaloyeros, Alain E, Welch, John T

“…A de novo, genetically engineered 687 residue polypeptide expressed in E. coli has been found to form highly rectilinear, β-sheet containing fibrillar…”
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Complex of Transfer-messenger RNA and Elongation Factor Tu by Zvereva, Maria I., Ivanov, Pavel V., Teraoka, Yoshika, Topilina, Natalya I., Dontsova, Olga A., Bogdanov, Alexey A., Kalkum, Markus, Nierhaus, Knud H., Shpanchenko, Olga V.

“…Transfer-messenger RNA (tmRNA) is a stable RNA in bacteria of 360 ± 40 nucleotides that can be charged with alanine and can function as both tRNA and mRNA…”
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SufB intein ofMycobacterium tuberculosisas a sensor for oxidative and nitrosative stresses by Topilina, Natalya I., Green, Cathleen M., Jayachandran, Pradeepa, Kelley, Danielle S., Stanger, Matthew J., Piazza, Carol Lyn, Nayak, Sasmita, Belfort, Marlene

“…Inteins are mobile genetic elements that self-splice at the protein level. Mycobacteria have inteins inserted into several important genes, including those…”
Get full text

Design and Preparation of beta2-Sheet Forming Repetitive and Block- Copolymerized Polypeptides by Higashiya, Seiichiro, Topilina, Natalya I, Ngo, Silvana C, Zagorevskii, Dmitri, Welch, John T

“…The design and rapid construction of libraries of genes coding beta2- sheet forming repetitive and block-copolymerized polypeptides bearing various C- and…”
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eta-sheet folding of 11-kDa fibrillogenic polypeptide is completely aggregation driven by Topilina, Natalya I, Ermolenkov, Vladimir V, Higashiya, Seiichiro, Welch, John T, Lednev, Igor K

“…A de novo polypeptide GH6[(GA)3GY(GA)3GE]8GAH6 (YE8) was designed and genetically engineered to form antiparallel -strands of GAGAGA repeats. Modulation of pH…”
Get full text

phi -sheet folding of 11-kDa fibrillogenic polypeptide is completely aggregation driven by Topilina, Natalya I, Ermolenkov, Vladimir V, Higashiya, Seiichiro, Welch, John T, Lednev, Igor K

“…A de novo polypeptide GH6[(GA)3GY(GA)3GE]8GAH6 (YE8) was designed and genetically engineered to form antiparallel -strands of GAGAGA repeats. Modulation of pH…”
Get full text