Search Results - "Topham, Matthew"

Regulation and Functions of Diacylglycerol Kinases by Shulga, Yulia V, Topham, Matthew K, Epand, Richard M

“…Shulga et al examine tne regulation and functions of diacylglycerol kinases (DGKs). They focus on DGKs biochemical and molecular activity…”
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Mammalian diacylglycerol kinases: Molecular interactions and biological functions of selected isoforms by Topham, Matthew K., Epand, Richard M.

“…The mammalian diacylglycerol kinases (DGK) are a group of enzymes having important roles in regulating many biological processes. Both the product and the…”
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Mice lacking DGKε show increased beige adipogenesis in visceral white adipose tissue after long-term high fat diet in a COX-2- dependent manner by Nakano, Tomoyuki, Topham, Matthew K., Goto, Kaoru

“…Adipose tissue is a central site for energy storage in the form of triglyceride (TG). Under excess energy conditions, TG is synthesized by acylation of…”
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Effect of Sulindac and Erlotinib vs Placebo on Duodenal Neoplasia in Familial Adenomatous Polyposis: A Randomized Clinical Trial by Samadder, N. Jewel, Neklason, Deborah W, Boucher, Kenneth M, Byrne, Kathryn R, Kanth, Priyanka, Samowitz, Wade, Jones, David, Tavtigian, Sean V, Done, Michelle W, Berry, Therese, Jasperson, Kory, Pappas, Lisa, Smith, Laurel, Sample, Danielle, Davis, Rian, Topham, Matthew K, Lynch, Patrick, Strait, Elena, McKinnon, Wendy, Burt, Randall W, Kuwada, Scott K

“…IMPORTANCE: Patients with familial adenomatous polyposis (FAP) are at markedly increased risk for duodenal polyps and cancer. Surgical and endoscopic…”
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Deletion of diacylglycerol kinase ε confers susceptibility to obesity via reduced lipolytic activity in murine adipocytes by Nakano, Tomoyuki, Seino, Keiko, Wakabayashi, Ichiro, Stafforini, Diana M., Topham, Matthew K., Goto, Kaoru

“…Lipid metabolism is closely involved with signal transduction and energy homeostasis. Excess calorie intake causes abnormal lipid metabolism, promoting obesity…”
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Signaling roles of diacylglycerol kinases by Topham, Matthew K.

“…Diacylglycerol kinases (DGKs) attenuate diacylglycerol signaling by converting this lipid to phosphatidic acid (PA). The nine mammalian DGKs that have been…”
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Diacylglycerol kinase ε localizes to subsurface cisterns of cerebellar Purkinje cells by Hozumi, Yasukazu, Fujiwara, Hiroki, Kaneko, Kenya, Fujii, Satoshi, Topham, Matthew K., Watanabe, Masahiko, Goto, Kaoru

“…Following activation of Gq protein-coupled receptors, phospholipase C yields a pair of second messengers: diacylglycerol (DG) and inositol 1,4,5-trisphosphate…”
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Ablation of DGKα facilitates α-smooth muscle actin expression via the Smad and PKCδ signaling pathways during the acute phase of CCl4-induced hepatic injury by Seino, Keiko, Nakano, Tomoyuki, Tanaka, Toshiaki, Hozumi, Yasukazu, Topham, Matthew K, Goto, Kaoru, Iseki, Ken

“…Expression of α-smooth muscle actin (αSMA) is constitutive in vascular smooth muscle cells, but is induced in nonmuscle cells such as hepatic stellate cells…”
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Downregulation of diacylglycerol kinase ζ enhances activation of cytokine-induced NF-κB signaling pathway by Tsuchiya, Rieko, Tanaka, Toshiaki, Hozumi, Yasukazu, Nakano, Tomoyuki, Okada, Masashi, Topham, Matthew K., Iino, Mitsuyoshi, Goto, Kaoru

“…The transcription factor NF-κB family serves as a key component of many pathophysiological events such as innate and adaptive immune response, inflammation,…”
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Disruption of diacylglycerol metabolism impairs the induction of T cell anergy by Koretzky, Gary A, Zhong, Xiao-Ping, Olenchock, Benjamin A, Guo, Rishu, Carpenter, Jeffery H, Jordan, Martha, Topham, Matthew K

“…Anergic T cells have altered diacylglycerol metabolism, but whether that altered metabolism has a causative function in the induction of T cell anergy is not…”
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Diacylglycerol kinases as sources of phosphatidic acid by Cai, Jinjin, Abramovici, Hanan, Gee, Stephen H., Topham, Matthew K.

“…There are ten mammalian diacylglycerol kinases (DGKs) whose primary role is to terminate diacylglycerol (DAG) signaling. However, it is becoming increasingly…”
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Phosphatidylinositol-4-phosphate 5-Kinase Isoforms Exhibit Acyl Chain Selectivity for Both Substrate and Lipid Activator by Shulga, Yulia V., Anderson, Richard A., Topham, Matthew K., Epand, Richard M.

“…Phosphatidylinositol 4,5-bisphosphate is mostly produced in the cell by phosphatidylinositol-4-phosphate 5-kinases (PIP5K) and has a crucial role in numerous…”
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Downregulation of Diacylglycerol Kinase Delta Contributes to Hyperglycemia-Induced Insulin Resistance by Chibalin, Alexander V., Leng, Ying, Vieira, Elaine, Krook, Anna, Björnholm, Marie, Long, Yun Chau, Kotova, Olga, Zhong, Zhihui, Sakane, Fumio, Steiler, Tatiana, Nylén, Carolina, Wang, Jianjun, Laakso, Markku, Topham, Matthew K., Gilbert, Marc, Wallberg-Henriksson, Harriet, Zierath, Juleen R.

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Study of Arachidonoyl Specificity in Two Enzymes of the PI Cycle by Shulga, Yulia V., Topham, Matthew K., Epand, Richard M.

“…We identified a conserved pattern of residues L-X(3-4)-R-X(2)-L-X(4)-G, in which -X(n)- is n residues of any amino acid, in two enzymes acting on the…”
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Downregulation of Diacylglycerol Kinase Delta Contributes to Hyperglycemia-Induced Insulin Resistance by Chibalin, Alexander V., Leng, Ying, Vieira, Elaine, Krook, Anna, Björnholm, Marie, Long, Yun Chau, Kotova, Olga, Zhong, Zhihui, Sakane, Fumio, Steiler, Tatiana, Nylén, Carolina, Wang, Jianjun, Laakso, Markku, Topham, Matthew K., Gilbert, Marc, Wallberg-Henriksson, Harriet, Zierath, Juleen R.

“…Type 2 (non-insulin-dependent) diabetes mellitus is a progressive metabolic disorder arising from genetic and environmental factors that impair beta cell…”
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Cytoplasmic localization of DGKζ exerts a protective effect against p53-mediated cytotoxicity by Tanaka, Toshiaki, Okada, Masashi, Hozumi, Yasukazu, Tachibana, Ken, Kitanaka, Chifumi, Hamamoto, Yoshioki, Martelli, Alberto M, Topham, Matthew K, Iino, Mitsuyoshi, Goto, Kaoru

“…The transcription factor p53 plays a crucial role in coordinating the cellular response to various stresses. Therefore, p53 protein levels and activity need to…”
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DGKE Variants Cause a Glomerular Microangiopathy That Mimics Membranoproliferative GN by OZALTIN, Fatih, BINGHUA LI, DUZOVA, Ali, OZEN, Seza, TOPALOGLU, Rezan, BESBAS, Nesrin, ASHRAF, Shazia, YONG DU, CHAOYING LIANG, CHEN, Phylip, DONGMEI LU, VADNAGARA, Komal, RAUHAUSER, Alysha, ARBUCKLE, Susan, LEWIS, Deborah, WAKELAND, Benjamin, QUIGG, Richard J, RANSOM, Richard F, WAKELAND, Edward K, TOPHAM, Matthew K, BAZAN, Nicolas G, MOHAN, Chandra, HILDEBRANDT, Friedhelm, AN, Sung-Wan, BAKKALOGLU, Aysin, HUANG, Chou-Long, ATTANASIO, Massimo, SOYLEMEZOGLU, Oguz, ISIK GONUL, Ipek, TASKIRAN, Ekim Z, IBSIRLIOGLU, Tulin, KORKMAZ, Emine, BILGINER, Yelda

“…Renal microangiopathies and membranoproliferative GN (MPGN) can manifest similar clinical presentations and histology, suggesting the possibility of a common…”
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DGK[zeta] Downregulation Enhances Osteoclast Differentiation and Bone Resorption Activity Under Inflammatory Conditions by Iwazaki, Kiyoshi, Tanaka, Toshiaki, Hozumi, Yasukazu, Okada, Masashi, Tsuchiya, Rieko, Iseki, Ken, Topham, Matthew K, Kawamae, Kaneyuki, Takagi, Michiaki, Goto, Kaoru

“…Bone homeostasis is maintained by a balance between resorption of the bone matrix and its replacement by new bone. Osteoclasts play a crucially important role…”
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DGKζ Downregulation Enhances Osteoclast Differentiation and Bone Resorption Activity Under Inflammatory Conditions by Iwazaki, Kiyoshi, Tanaka, Toshiaki, Hozumi, Yasukazu, Okada, Masashi, Tsuchiya, Rieko, Iseki, Ken, Topham, Matthew K., Kawamae, Kaneyuki, Takagi, Michiaki, Goto, Kaoru

“…Bone homeostasis is maintained by a balance between resorption of the bone matrix and its replacement by new bone. Osteoclasts play a crucially important role…”
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Role of the N-terminal hydrophobic residues of DGKε in targeting the endoplasmic reticulum by Matsui, Hirooki, Hozumi, Yasukazu, Tanaka, Toshiaki, Okada, Masashi, Nakano, Tomoyuki, Suzuki, Yusuke, Iseki, Ken, Kakehata, Seiji, Topham, Matthew K., Goto, Kaoru

“…The endoplasmic reticulum (ER), comprised of an interconnected membrane network, is a site of phospholipid and protein synthesis. The diacylglycerol kinase…”
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