Search Results - "Topcu, Z."

DNA topoisomerases as targets for anticancer drugs by Topcu, Z.

“…DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA…”
Get full text

Structural modification of ellipticine derivatives with alkyl groups of varying length is influential on their effects on human DNA topoisomerase II: a combined experimental and computational study by Kuskucu, M., Akyildiz, V., Kulmány, Á., Ergün, Y., Zencir, S., Zupko, I., Durdagi, S., Zaka, M., Sahin, K., Orhan, H., Topcu, Z.

“…The compounds reducing tumor cell viability and disrupting DNA topoisomerase reactions have been widely used in anticancer drug development. Ellipticine…”
Get full text

Imatinib-induced apoptosis: a possible link to topoisomerase enzyme inhibition by Baran, Y., Zencir, S., Cakir, Z., Ozturk, E., Topcu, Z.

“…Summary What is known and Objective:  Imatinib is a specific BCR/ABL inhibitor, commonly used for the treatment of chronic myeloid leukaemia (CML), a…”
Get full text

CYP2A6 gene deletion reduces oral cancer risk in betel quid chewers in Sri Lanka by Topcu, Zeki, Chiba, Itsuo, Fujieda, Masaki, Shibata, Toshiyuki, Ariyoshi, Noritaka, Yamazaki, Hiroshi, Sevgican, Figen, Muthumala, Malsantha, Kobayashi, Hiroshi, Kamataki, Tetsuya

“…We investigated the relationship between inter-individual difference in CYP2A6 genotype and susceptibility to oral cancer among habitual betel quid chewers in…”
Get full text

RT-PCR-based cytochrome P450 expression profile of oral tissue samples by Sarikaya, D., Chiba, I., Bilgen, C., KamatakiI, T., Topcu, Z.

“…To analyse the expression of individual forms of cytochrome P450 (CYP) at the mRNA level in five homogenized oral buccal tissue samples from four individuals…”
Get full text

Telomeric restriction analysis of vascular smooth muscle cells following balloon angioplasty in rabbits by Ozsarlak-Sozer, G., Kerry, Z., Oran, I., Gokce, G., Tosun, M., Bechard, L., Reel, B., Yasa, M., Lebe, B., Topcu, Z.

“…Intimal hyperplasia due to smooth muscle cell proliferation and migration has been reported to be responsible for the pathogenesis of atherosclerosis and…”
Get full text

Effect of some bis-mannich bases and corresponding piperidinols on DNA topoisomerase I as a possible mechanism of their cytotoxic actions by Canturk, P, Kucukoglu, K, Topcu, Z, Gul, M, Gul, H.I

Get full text

The yeast two-hybrid system and its pharmaceutical significance by TOPCU, Zeki, BORDEN, Katherine L. B

“…The detected phenotypes in many diseases are caused from dysfunction in protein-protein, protein-DNA and receptor-ligand interactions. Therefore, determination…”
Get full text

Cytotoxic activity of 4′-hydroxychalcone derivatives against Jurkat cells and their effects on mammalian DNA topoisomerase I by Canturk, P, Gul, I, Cizmecioglu, M, Zencir, S, Gul, M, Atalay, M, Topcu, Z

Get full text

Imatinib-induced apoptosis: a possible link to topoisomerase enzyme inhibition: Activity evaluation of imatinib by Baran, Y., Zencir, S., Cakir, Z., Ozturk, E., Topcu, Z.

Get full text

"Do not tell": what factors affect relatives' attitudes to honest disclosure of diagnosis to cancer patients? by Ozdogan, Mustafa, Samur, Mustafa, Bozcuk, Hakan Sat, Coban, Erkan, Artac, Mehmet, Savas, Burhan, Kara, Arzu, Topcu, Zekiye, Sualp, Yeliz

“…Disclosure of the diagnosis of cancer to patients is a difficult task for physicians in developing countries. Family members often oppose truth telling. The…”
Get full text

1H-Benzimidazole derivatives as mammalian DNA topoisomerase I inhibitors by Alpan, A Selcen, Gunes, H Semih, Topcu, Zeki

“…Benzimidazole is one of the most important heterocyclic groups manifesting various biological properties, such as antibacterial, antifungal, antimicrobial,…”
Get full text

Abrupt disruption of capping and a single source for recombinationally elongated telomeres in Kluyveromyces lactis by Topcu, Z, Nickles, K, Davis, C, McEachern, M.J

“…Eukaryotic cells, including some human cancers, that lack telomerase can sometimes maintain telomeres by using recombination. It was recently proposed that…”
Get full text

RT-PCR-based cytochrome P450 expression profile of oral tissue samples1: CYP expression in oral tissue by Sarikaya, D., Chiba, I., Bilgen, C., KamatakiI, T., Topcu, Z.

Get full text

RT‐PCR‐based cytochrome P450 expression profile of oral tissue samples1 by Sarikaya, D., Chiba, I., Bilgen, C., KamatakiI, T., Topcu, Z.

“…Summary Objective:  To analyse the expression of individual forms of cytochrome P450 (CYP) at the mRNA level in five homogenized oral buccal tissue samples…”
Get full text

Densitometric quantification of DNA topoisomers in ethidium bromide-stained agarose gels and chemiluminescence-detected X ray films by Topcu, Z

“…This study investigates the contribution of deformational strain imposed by topological interconversions of DNA in ethidium bromide-binding on agarose gels…”
Get full text

An optimized recipe for cloning of the polymerase chain reaction-amplified DNA inserts into plasmid vectors by Topcu, Z

“…This study compares a number of parameters that are important in the ligation of the polymerase chain reaction-amplified DNA inserts into plasmid vectors and…”
Get full text

Does music exposure during chemotherapy improve quality of life in early breast cancer patients? A pilot study by Bozcuk, Hakan, Artac, Mehmet, Kara, Arzu, Ozdogan, Mustafa, Sualp, Yeliz, Topcu, Zekiye, Karaagacli, Ayse, Yildiz, Mustafa, Savas, Burhan

“…Adjuvant chemotherapy is associated with poor quality of life (qol) in breast cancer patients. We tested the effect of listening to music during chemotherapy…”
Get more information

The promyelocytic leukemia protein PML interacts with the proline-rich homeodomain protein PRH : a RING may link hematopoiesis and growth control by TOPCU, Z, MACK, D. L, HROMAS, R. A, BORDEN, K. L. B

“…Acute promyelocytic leukemia (APL) is characterized by a block in myeloid cell differentiation. As a result of a chromosomal translocation in these patients,…”
Get full text

The Role of Shared Book Reading on Early Literacy: The Effects in terms of Home and School Environment by Figen Turan, Z. Güzin Topcu

“…Shared book reading is a social activity in which an adult reads a book to a child or a group of children by expecting a different rate of participation from…”
Get full text