Search Results - "Topaz, Nadav"
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Genomic characterization of Haemophilus influenzae: a focus on the capsule locus
Published in BMC genomics (12-10-2019)“…Haemophilus influenzae (Hi) can cause invasive diseases such as meningitis, pneumonia, or sepsis. Typeable Hi includes six serotypes (a through f), each…”
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Genetic Similarity of Gonococcal Homologs to Meningococcal Outer Membrane Proteins of Serogroup B Vaccine
Published in mBio (10-09-2019)“…The human pathogens and share high genome identity. Retrospective analysis of surveillance data from New Zealand indicates the potential cross-protective…”
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High Risk for Invasive Meningococcal Disease Among Patients Receiving Eculizumab (Soliris) Despite Receipt of Meningococcal Vaccine
Published in MMWR. Morbidity and mortality weekly report (14-07-2017)“…Use of eculizumab (Soliris, Alexion Pharmaceuticals), a terminal complement inhibitor, is associated with a 1,000-fold to 2,000-fold increased incidence of…”
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BMScan: using whole genome similarity to rapidly and accurately identify bacterial meningitis causing species
Published in BMC infectious diseases (15-08-2018)“…Bacterial meningitis is a life-threatening infection that remains a public health concern. Bacterial meningitis is commonly caused by the following species:…”
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Phylogenetic Structure and Comparative Genomics of Multi-National Invasive Haemophilus influenzae Serotype a Isolates
Published in Frontiers in microbiology (24-03-2022)“…Recent reports have indicated a rise of invasive disease caused by serotype a (Hia) in North America and some European countries. The whole-genome sequences…”
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Genetic Features of a Representative Panel of 110 Meningococcal B Isolates to Assess the Efficacy of Meningococcal B Vaccines
Published in mSphere (26-10-2022)“…Predictions of vaccine efficacy against Neisseria meningitidis serogroup B (NmB) disease are hindered by antigenic variability, limiting the representativeness…”
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Genetic Diversity of Meningococcal Serogroup B Vaccine Antigens among Carriage Isolates Collected from Students at Three Universities in the United States, 2015-2016
Published in mBio (18-05-2021)“…Carriage evaluations were conducted during 2015 to 2016 at two U.S. universities in conjunction with the response to disease outbreaks caused by serogroup B…”
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Web-Based Genome Analysis of Bacterial Meningitis Pathogens for Public Health Applications Using the Bacterial Meningitis Genomic Analysis Platform (BMGAP)
Published in Frontiers in genetics (26-11-2020)“…Effective laboratory-based surveillance and public health response to bacterial meningitis depends on timely characterization of bacterial meningitis…”
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Genomic Insights on Variation Underlying Capsule Expression in Meningococcal Carriage Isolates From University Students, United States, 2015-2016
Published in Frontiers in microbiology (17-02-2022)“…In January and February 2015, serogroup B (NmB) outbreaks occurred at two universities in the United States, and mass vaccination campaigns using MenB vaccines…”
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Neisseria meningitidis Serogroup C Clonal Complex 10217 Outbreak in West Kpendjal Prefecture, Togo 2019
Published in Microbiology spectrum (27-04-2022)“…Togo has reported seasonal meningitis outbreaks caused by non-Neisseria meningitidis serogroup A (NmA) pathogens since the introduction of meningococcal…”
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Insights on Population Structure and Within-Host Genetic Changes among Meningococcal Carriage Isolates from U.S. Universities
Published in mSphere (08-04-2020)“…In 2015 and 2016, meningococcal carriage evaluations were conducted at two universities in the United States following mass vaccination campaigns in response…”
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Evaluating a Cluster and the Overall Trend of Invasive Haemophilus influenzae Serotype b in Alaska 2005–2019
Published in The Pediatric infectious disease journal (21-01-2022)Get full text
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Enhancing Meningococcal Genomic Surveillance in the Meningitis Belt Using High-Resolution Culture-Free Whole-Genome Sequencing
Published in The Journal of infectious diseases (04-09-2022)“…Abstract Rollout of meningococcal serogroup A conjugate vaccine in Africa started in 2010, aiming to eliminate meningitis outbreaks, in meningitis belt…”
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Serogroup A, C, W, and Y meningococcal disease in persons previously vaccinated with a serogroup ACWY meningococcal vaccine – United States, 2014–2018
Published in Vaccine (20-12-2021)“…The Advisory Committee on Immunization Practices (ACIP) recommends routine vaccination with a quadrivalent meningococcal conjugate serogroup A,C,W,Y (MenACWY)…”
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Evaluating a Cluster and the Overall Trend of Invasive Haemophilus influenzae Serotype b in Alaska 2005–2019
Published in The Pediatric infectious disease journal (01-04-2022)“…In 2019, 5 cases of invasive Haemophilus influenzae serotype b (Hib) occurred in the Anchorage region of Alaska over a period of 16 days. No cases had occurred…”
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Direct Real-Time PCR for the Detection and Serotyping of Haemophilus influenzae without DNA Extraction
Published in Journal of clinical microbiology (20-04-2022)“…To monitor the burden and changes in Haemophilus influenzae (Hi) disease, direct real-time PCR (drt-PCR) assays have been developed for Hi detection in…”
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Whole-Genome Sequencing for Characterization of Capsule Locus and Prediction of Serogroup of Invasive Meningococcal Isolates
Published in Journal of clinical microbiology (01-03-2019)“…Invasive meningococcal disease is mainly caused by serogroups A, B, C, X, W, and Y. The serogroup is typically determined by slide agglutination serogrouping…”
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Genomic Diversity of Haemophilus influenzae Serotype a in an Outbreak Community-Alaska, 2018
Published in The Journal of infectious diseases (01-02-2022)“…Haemophilus influenzae serotype a (Hia) can cause severe invasive disease, especially in young children. In 2018, 4 invasive Hia cases occurred in an Alaska…”
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