Search Results - "Toosi, Behzad M."

The EphB6 Receptor: Kinase-Dead but Very Much Alive by Strozen, Timothy G., Sharpe, Jessica C., Harris, Evelyn D., Uppalapati, Maruti, Toosi, Behzad M.

“…The Eph receptor tyrosine kinase member EphB6 is a pseudokinase, and similar to other pseudoenzymes has not attracted an equivalent amount of interest as its…”
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Acute intermittent hypoxia and rehabilitative training following cervical spinal injury alters neuronal hypoxia- and plasticity-associated protein expression by Hassan, Atiq, Arnold, Breanna M, Caine, Sally, Toosi, Behzad M, Verge, Valerie M K, Muir, Gillian D

“…One of the most promising approaches to improve recovery after spinal cord injury (SCI) is the augmentation of spontaneously occurring plasticity in uninjured…”
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An integrated computational and experimental study uncovers FUT9 as a metabolic driver of colorectal cancer by Auslander, Noam, Cunningham, Chelsea E, Toosi, Behzad M, McEwen, Emily J, Yizhak, Keren, Vizeacoumar, Frederick S, Parameswaran, Sreejit, Gonen, Nir, Freywald, Tanya, Bhanumathy, Kalpana K, Freywald, Andrew, Vizeacoumar, Franco J, Ruppin, Eytan

“…Metabolic alterations play an important role in cancer and yet, few metabolic cancer driver genes are known. Here we perform a combined genomic and metabolic…”
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Integration of cancer-related genetic landscape of Eph receptors and ephrins with proteomics identifies a crosstalk between EPHB6 and EGFR by Hanover, Glinton, Vizeacoumar, Frederick S., Banerjee, Sara L., Nair, Raveena, Dahiya, Renuka, Osornio-Hernandez, Ana I., Morales, Alain Morejon, Freywald, Tanya, Himanen, Juha P., Toosi, Behzad M., Bisson, Nicolas, Vizeacoumar, Franco J., Freywald, Andrew

“…Eph receptors and their ephrin ligands are viewed as promising targets for cancer treatment; however, targeting them is hindered by their context-dependent…”
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The EphA2 Receptor Regulates Invasiveness and Drug Sensitivity in Canine and Human Osteosarcoma Cells by Harris, Evelyn D, Sharpe, Jessica C, Strozen, Timothy, Abdi, Shabnam, Kliewer, Maya, Sanchez, Malkon G, Hogan, Natacha S, MacDonald-Dickinson, Valerie, Vizeacoumar, Franco J, Toosi, Behzad M

“…Osteosarcoma is an aggressive bone cancer affecting both humans and dogs, often leading to pulmonary metastasis. Despite surgery and chemotherapy being the…”
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The intrinsically kinase-inactive EPHB6 receptor predisposes cancer cells to DR5-induced apoptosis by promoting mitochondrial fragmentation by El Zawily, Amr M, Toosi, Behzad M, Freywald, Tanya, Indukuri, Vijaya V, Vizeacoumar, Franco J, Leary, Scot C, Freywald, Andrew

“…Death Receptor 5 (DR5) is a promising target for cancer therapy due to its ability to selectively induce apoptosis in cancer cells. However, the therapeutic…”
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Molecular characterization of an MLL1 fusion and its role in chromosomal instability by Parameswaran, Sreejit, Vizeacoumar, Frederick S., Kalyanasundaram Bhanumathy, Kalpana, Qin, Fujun, Islam, Md. Fahmid, Toosi, Behzad M., Cunningham, Chelsea E., Mousseau, Darrell D., Uppalapati, Maruti C., Stirling, Peter C., Wu, Yuliang, Bonham, Keith, Freywald, Andrew, Li, Hui, Vizeacoumar, Franco J.

“…Chromosomal rearrangements involving the mixed‐lineage leukemia (MLL1) gene are common in a unique group of acute leukemias, with more than 100 fusion partners…”
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Markers of ovarian antral follicular development in sheep: comparison of follicles destined to ovulate from the final or penultimate follicular wave of the estrous cycle by Seekallu, Srinivas V, Toosi, Behzad M, Grazul-Bilska, Anna T, Rawlings, Norman C

“…Treatment of non-prolific western white-faced ewes with prostaglandin F2α (PGF2α) and medroxyprogesterone acetate (MAP) increases the ovulation rate as a…”
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Prolonged acute intermittent hypoxia improves forelimb reach-to-grasp function in a rat model of chronic cervical spinal cord injury by Arnold, Breanna M., Toosi, Behzad M., Caine, Sally, Mitchell, Gordon S., Muir, Gillian D.

“…Repetitive acute intermittent hypoxia (AIH – brief, episodes of low inspired oxygen) elicits spinal motor plasticity, resulting in sustained improvements of…”
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A Systematic Investigation into the Influence of Net Charge on the Biological Distribution of Radiometalated Peptides Using [68Ga]Ga-DOTA-TATE Derivatives by Raheem, Shvan J., Salih, Akam K., Garcia, Moralba Dominguez, Sharpe, Jessica C., Toosi, Behzad M., Price, Eric W.

“…Recently, several radiometalated peptides have been approved for clinical imaging and/or therapy (theranostics) of several types of cancer; nonetheless, the…”
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A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy by El Zawily, Amr, Vizeacoumar, Frederick S, Dahiya, Renuka, Banerjee, Sara L, Bhanumathy, Kalpana K, Elhasasna, Hussain, Hanover, Glinton, Sharpe, Jessica C, Sanchez, Malkon G, Greidanus, Paul, Stacey, R Greg, Moon, Kyung-Mee, Alexandrov, Ilya, Himanen, Juha P, Nikolov, Dimitar B, Fonge, Humphrey, White, Aaron P, Foster, Leonard J, Wang, Bingcheng, Toosi, Behzad M, Bisson, Nicolas, Mirzabekov, Tajib A, Vizeacoumar, Franco J, Freywald, Andrew

“…Accumulating analyses of pro-oncogenic molecular mechanisms triggered a rapid development of targeted cancer therapies. Although many of these treatments…”
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LH pulse frequency and the emergence and growth of ovarian antral follicular waves in the ewe during the luteal phase of the estrous cycle by Seekallu, Srinivas V, Toosi, Behzad M, Rawlings, Norman C

“…In the ewe, ovarian antral follicles emerge or grow from a pool of 2-3 mm follicles in a wave like pattern, reaching greater than or equal to 5 mm in diameter…”
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EPHB6 augments both development and drug sensitivity of triple-negative breast cancer tumours by Toosi, Behzad M., El Zawily, Amr, Truitt, Luke, Shannon, Matthew, Allonby, Odette, Babu, Mohan, DeCoteau, John, Mousseau, Darrell, Ali, Mohsin, Freywald, Tanya, Gall, Amanda, Vizeacoumar, Frederick S., Kirzinger, Morgan W., Geyer, C. Ronald, Anderson, Deborah H., Kim, TaeHyung, Welm, Alana L., Siegel, Peter, Vizeacoumar, Franco J., Kusalik, Anthony, Freywald, Andrew

“…Triple-negative breast cancer (TNBC) tumours that lack expression of oestrogen, and progesterone receptors, and do not overexpress the HER2 receptor represent…”
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Superovulation and embryo transfer in wood bison (Bison bison athabascae) by Toosi, Behzad M., Tribulo, Andres, Lessard, Carl, Mastromonaco, Gabriela F., McCorkell, Robert B., Adams, Gregg P.

“…Two experiments were done to develop an effective superovulatory treatment protocol in wood bison for the purpose of embryo collection and transfer. In…”
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Effects of the Rate and Duration of Physiological Increases in Serum FSH Concentrations on Emergence of Follicular Waves in Cyclic Ewes by Toosi, Behzad M, Seekallu, Srinivas V, Rawlings, Norman C

“…Large antral follicles grow in waves in the ewe, with each wave triggered by a peak in serum FSH concentrations. In this study, our objectives were to…”
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Effects of the Rate and Duration of Physiological Increases in Serum FSH Concentrations on Emergence of Follicular Waves in Cyclic Ewes1 by Toosi, Behzad M, Seekallu, Srinivas V, Rawlings, Norman C

“…Large antral follicles grow in waves in the ewe, with each wave triggered by a peak in serum FSH concentrations. In this study, our objectives were to…”
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Pulsed GnRH secretion and the FSH secretory peaks that initiate ovarian antral follicular wave emergence in anestrous ewes by Seekallu, Srinivas V., Toosi, Behzad M., Ziegler, Ashley, Reeves, Jerry J., Rawlings, Norman C.

“…In ewes, immunization against GnRH blocks LH pulses but mean serum FSH concentrations are only partly reduced; the fate of the FSH peaks that precede ovarian…”
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Ovarian Follicular Dominance and the Induction of Daily Follicular Waves in the Ewe1 by Toosi, Behzad M, Davies, Kate L, Seekallu, Srinivas V, Ziegler, Ashley C, Barrett, David M.W, Duggavathi, Rajesha, Rawlings, Norman C

“…Large antral follicles grow in waves in the ewe, and each wave is triggered by a peak in serum concentrations of FSH. The existence of follicular dominance in…”
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Ovarian Follicular Dominance and the Induction of Daily Follicular Waves in the Ewe by Toosi, Behzad M, Davies, Kate L, Seekallu, Srinivas V, Ziegler, Ashley C, Barrett, David M.W, Duggavathi, Rajesha, Rawlings, Norman C

“…Large antral follicles grow in waves in the ewe, and each wave is triggered by a peak in serum concentrations of FSH. The existence of follicular dominance in…”
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Pulsatile LH secretion and ovarian follicular wave emergence and growth in anestrous ewes by Seekallu, Srinivas V., Barrett, David M.W., Toosi, Behzad M., Clarke, Kelsey, Ewen, Kirk A., Duggavathi, Rajesha, Davies, Kate L., Pattullo, Kim M., Bagu, Edward T., Rawlings, Norman C.

“…The objective of this study was to determine if pulsatile LH secretion was needed for ovarian follicular wave emergence and growth in the anestrous ewe. In…”
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