Search Results - "Toor, Salman"

Immune checkpoint inhibitors: recent progress and potential biomarkers by Darvin, Pramod, Toor, Salman M., Sasidharan Nair, Varun, Elkord, Eyad

“…Cancer growth and progression are associated with immune suppression. Cancer cells have the ability to activate different immune checkpoint pathways that…”
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Immune checkpoints in the tumor microenvironment by Toor, Salman M., Sasidharan Nair, Varun, Decock, Julie, Elkord, Eyad

“…Interactions between immune checkpoints (ICs) and their ligands negatively regulate T cell activation pathways involved in physiological immune responses…”
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T‐cell responses and therapies against SARS‐CoV‐2 infection by Toor, Salman M., Saleh, Reem, Sasidharan Nair, Varun, Taha, Rowaida Z., Elkord, Eyad

“…Coronavirus disease 2019 (COVID‐19) is caused by SARS‐CoV‐2, a novel coronavirus strain. Some studies suggest that COVID‐19 could be an immune‐related disease,…”
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Therapeutic prospects of targeting myeloid‐derived suppressor cells and immune checkpoints in cancer by Toor, Salman M, Elkord, Eyad

“…Immune evasion is a characteristic of most human malignancies and is induced via various mechanisms. Immunosuppressive cells, including myeloid‐derived…”
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Immune Checkpoints in Circulating and Tumor-Infiltrating CD4 + T Cell Subsets in Colorectal Cancer Patients by Toor, Salman M, Murshed, Khaled, Al-Dhaheri, Mahmood, Khawar, Mahwish, Abu Nada, Mohamed, Elkord, Eyad

“…Blockade of inhibitory immune checkpoints (ICs) is a promising therapeutic approach; however, it has shown limited success in some cancers including colorectal…”
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Role of Epigenetic Modifications in Inhibitory Immune Checkpoints in Cancer Development and Progression by Saleh, Reem, Toor, Salman M, Sasidharan Nair, Varun, Elkord, Eyad

“…A balance between co-inhibitory and co-stimulatory signals in the tumor microenvironment (TME) is critical to suppress tumor development and progression,…”
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Targeting TIM-3 in solid tumors: innovations in the preclinical and translational realm and therapeutic potential by Saleh, Reem, Toor, Salman M, Elkord, Eyad

“…Immune checkpoint inhibitors (ICIs) have shown a great therapeutic efficacy in cancer patients. However, a significant proportion of cancer patients remain…”
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Expression of immune checkpoints and T cell exhaustion markers in early and advanced stages of colorectal cancer by Saleh, Reem, Taha, Rowaida Z., Toor, Salman M., Sasidharan Nair, Varun, Murshed, Khaled, Khawar, Mahwish, Al-Dhaheri, Mahmood, Petkar, Mahir Abdulla, Abu Nada, Mohamed, Elkord, Eyad

“…Despite recent advances in colorectal cancer (CRC) treatment, a large proportion of patients show limited responses to therapies, especially in advanced…”
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An evaluation of sorter induced cell stress (SICS) on peripheral blood mononuclear cells (PBMCs) after different sort conditions - Are your sorted cells getting SICS? by Pfister, Gerald, Toor, Salman M., Sasidharan Nair, Varun, Elkord, Eyad

“…Flow cytometry and fluorescence-activated cell sorting have become invaluable tools to analyze and isolate specific cell populations in a wide range of…”
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Breast Cancer Cells and PD-1/PD-L1 Blockade Upregulate the Expression of PD-1, CTLA-4, TIM-3 and LAG-3 Immune Checkpoints in CD4 + T Cells by Saleh, Reem, Toor, Salman M, Khalaf, Sarah, Elkord, Eyad

“…Triple negative breast cancer (TNBC) is the most aggressive breast cancer subtype, and it exhibits resistance to common breast cancer therapies. Immune…”
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Transcriptomic Analyses Revealed Systemic Alterations in Gene Expression in Circulation and Tumor Microenvironment of Colorectal Cancer Patients by Shaath, Hibah, Toor, Salman M, Nair, Varun Sasidharan, Elkord, Eyad, Alajez, Nehad M

“…Colorectal cancer (CRC) is among the leading causes of cancer-related deaths worldwide, underscoring a need for better understanding of the disease and…”
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DNA methylation and repressive histones in the promoters of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, PD-L1, and galectin-9 genes in human colorectal cancer by Sasidharan Nair, Varun, Toor, Salman M, Taha, Rowaida Z, Shaath, Hibah, Elkord, Eyad

“…Colorectal cancer (CRC) is the third most commonly diagnosed human malignancy worldwide. Upregulation of inhibitory immune checkpoints by tumor-infiltrating…”
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Myeloid cells in circulation and tumor microenvironment of breast cancer patients by Toor, Salman M., Syed Khaja, Azharuddin Sajid, El Salhat, Haytham, Faour, Issam, Kanbar, Jihad, Quadri, Asif A., Albashir, Mohamed, Elkord, Eyad

“…Pathological conditions including cancers lead to accumulation of a morphological mixture of highly immunosuppressive cells termed as myeloid-derived…”
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Preferential accumulation of regulatory T cells with highly immunosuppressive characteristics in breast tumor microenvironment by Syed Khaja, Azharuddin Sajid, Toor, Salman M, El Salhat, Haytham, Faour, Issam, Ul Haq, Navid, Ali, Bassam R, Elkord, Eyad

“…Immunosuppressive cells such as regulatory T cells (Tregs) have an ambiguous role in breast cancer prognosis, with studies reporting both positive and negative…”
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Pembrolizumab Interferes with the Differentiation of Human FOXP3 + -Induced T Regulatory Cells, but Not with FOXP3 Stability, through Activation of mTOR by Sasidharan Nair, Varun, Toor, Salman M, Taouk, Ghina, Pfister, Gerald, Ouararhni, Khalid, Alajez, Nehad M, Elkord, Eyad

“…Programmed cell death 1 (PD-1) is critical for T regulatory cells (Tregs) to maintain peripheral tolerance to self-antigens. In the tumor microenvironment,…”
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Increased Levels of Circulating and Tumor-Infiltrating Granulocytic Myeloid Cells in Colorectal Cancer Patients by Toor, Salman M, Syed Khaja, Azharuddin Sajid, El Salhat, Haytham, Bekdache, Omar, Kanbar, Jihad, Jaloudi, Mohammed, Elkord, Eyad

“…Increased levels of myeloid cells, especially myeloid-derived suppressor cells (MDSCs), have been reported to correlate with bad prognosis and reduced survival…”
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DNA methylation in the promoters of PD-L1, MMP9, ARG1, galectin-9, TIM-3, VISTA and TGF-β genes in HLA-DR- myeloid cells, compared with HLA-DR+ antigen-presenting cells by Saleh, Reem, Toor, Salman M., Taha, Rowaida Z., Al-Ali, Dana, Sasidharan Nair, Varun, Elkord, Eyad

“…Myeloid cells, including antigen-presenting cells (APCs) and myeloid-derived suppressor cells (MDSCs) play opposing roles to orchestrate innate and adaptive…”
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Metabolic reprogramming of T regulatory cells in the hypoxic tumor microenvironment by Sasidharan Nair, Varun, Saleh, Reem, Toor, Salman M., Cyprian, Farhan S., Elkord, Eyad

“…Metabolic dysregulation in the hypoxic tumor microenvironment (TME) is considered as a hallmark of solid tumors, leading to changes in biosynthetic pathways…”
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Comprehensive Transcriptomic Profiling of Murine Osteoclast Differentiation Reveals Novel Differentially Expressed Genes and LncRNAs by Toor, Salman M., Wani, Sachin, Albagha, Omar M. E.

“…Osteoclasts are the sole bone resorbing cells, which undertake opposing roles to osteoblasts to affect skeletal mass and structure. However, unraveling the…”
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The Genetic Spectrum of Maturity-Onset Diabetes of the Young (MODY) in Qatar, a Population-Based Study by Elashi, Asma A, Toor, Salman M, Diboun, Ilhame, Al-Sarraj, Yasser, Taheri, Shahrad, Suhre, Karsten, Abou-Samra, Abdul Badi, Albagha, Omar M E

“…Maturity-onset diabetes of the young (MODY) is a rare monogenic form of diabetes mellitus. In this study, we estimated the prevalence and genetic spectrum of…”
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