Search Results - "Toomey, J R"

Targeted disruption of the murine tissue factor gene results in embryonic lethality by TOOMEY, J. R, KRATZER, K. E, LASKY, N. M, STANTON, J. J, BROZE, G. J

“…Tissue factor (TF) is an integral membrane glycoprotein that is believed to be the physiologic initiator of the blood coagulation cascade. Disruption of the…”
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Radiographers' assessment of referrals for CT and MR imaging using a web-based data collection tool by Chilanga, C.C., Lysdahl, K.B., Olerud, H.M., Toomey, R.J., Cradock, A., Rainford, L.

“…There is limited research related to the radiographers' role in assessing of radiology referrals to justify imaging. This study investigated radiographers'…”
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The pop-up research centre – Challenges and opportunities by Toomey, R.J., McEntee, M.F., Rainford, L.A.

“…This article sets out to describe the concept of the “pop-up” research centre as a means to promote and develop radiography research locally, nationally and…”
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Localization of the human tissue factor recognition determinant of human factor VIIa by TOOMEY, J. R, SMITH, K. J, STAFFORD, D. W

“…Tissue factor is an integral membrane glycoprotein that serves as an essential cofactor for the blood coagulation factor VIIa. Recent studies have attempted to…”
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P2X1 stimulation promotes thrombin receptor‐mediated platelet aggregation by ERHARDT, J. A., TOOMEY, J. R., DOUGLAS, S. A., JOHNS, D. G.

“…P2X1 receptors are ATP‐gated channel demonstrated to be involved in multiple platelet responses, although in vitro analysis has been complicated by the effects…”
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A comparison of the β‐D‐xyloside, odiparcil, to warfarin in a rat model of venous thrombosis by TOOMEY, J. R., ABBOUD, M. A., VALOCIK, R. E., KOSTER, P. F., BURNS‐KURTIS, C. L., PILLARISETTI, K., DANOFF, T. M., ERHARDT, J. A.

“…Summary  Background: A significant need exists for new chronic oral anticoagulation therapies to replace warfarin. Previous studies have shown that…”
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Severe factor XI deficiency caused by a Gly555 to Glu mutation (factor XI–Glu555): a cross‐reactive material positive variant defective in factor IX activation by Zivelin, A., Ogawa, T., Bulvik, S., Landau, M., Toomey, J. R., Lane, J., Seligsohn, U., Gailani, D.

“…During normal hemostasis, the coagulation protease factor (F)XIa activates FIX. Hereditary deficiency of the FXIa precursor, FXI, is usually associated with…”
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The quest for Factor VIIa exosite inhibitors by Amour, A, Hutchinson, J, Ruiz Avendaño, A M, Ratcliffe, S, Alvarez, E, Martin, J, Toomey, J R, Senger, S, Wolfendale, M, Mooney, C

“…Coagulation proteases are involved in a highly orchestrated proteolytic cascade which is essential for haemostasis and blood clotting. In particular, the…”
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Antithrombotic Efficacy of a Novel Murine Antihuman Factor IX Antibody in Rats by Feuerstein, Giora Z, Patel, Arun, Toomey, John R, Bugelski, Peter, Nichols, Andrew J, Church, William R, Valocik, Richard, Koster, Paul, Baker, Audrey, Blackburn, Michael N

“…A murine antihuman factor IX monoclonal antibody (BC2) has been generated and evaluated for its capacity to prolong the activated partial thromboplastin time…”
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Potentiation of platelet activation through the stimulation of P2X1 receptors by Erhardt, J. A., Pillarisetti, K., Toomey, J. R.

“…The platelet P2X1 purinergic receptor is a ligand‐gated ion channel that responds to ATP. The precise role of P2X1 in platelet function is unknown, though…”
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An inhibitory anti-factor IX antibody effectively reduces thrombus formation in a rat model of venous thrombosis by Feuerstein, G Z, Toomey, J R, Valocik, R, Koster, P, Patel, A, Blackburn, M N

“…An inhibitory anti-factor IX/IXa antibody (BC2) has been investigated as an anti-thrombotic agent in a rat venous thrombosis model. The treatment of rats…”
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Localization of a Factor VIII-Inhibiting Antibody Epitope to a Region between Residues 338 and 362 of Factor VIII Heavy Chain by Ware, Jerry, Toomey, John R., Stafford, Darrel W.

“…We have used a recombinant DNA epitope library to localize the binding region of a factor VIII (FVIII) monoclonal antibody that neutralizes coagulant activity…”
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Epitope localization of anti-factor VIII monoclonal antibodies determined by recombinant peptides by Ware, J, Toomey, J R, Stafford, D W

“…In order to define the epitopes recognized by anti-coagulation factor VIII (FVIII) monoclonal antibodies, we have constructed a recombinant DNA epitope library…”
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The endothelial cell binding determinant of human factor IX resides in the .gamma.-carboxyglutamic acid domain by Toomey, John R, Smith, Kenneth J, Roberts, Harold R, Stafford, Darrel W

“…The blood coagulation factor IX(a) binds specifically to a site on endothelial cells with a Kd of 2.0-3.0 nM. A number of previous studies have attempted to…”
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Targeted disruption of the murine tissue factor gene results in embryonic lethality by Toomey, JR, Kratzer, KE, Lasky, NM, Stanton, JJ, Broze, GJ Jr

“…Tissue factor (TF) is an integral membrane glycoprotein that is believed to be the physiologic initiator of the blood coagulation cascade. Disruption of the…”
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Effect of Tissue Factor Deficiency on Mouse and Tumor Development by Toomey, John R., Kratzer, Kenneth E., Lasky, Nina M., Broze, George J.

“…Previous reports suggest that tissue factor (TF) may play an essential role in embryonic vascular development and tumor angiogenesis. To further examine this…”
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Comparing the Antithrombotic Efficacy of a Humanized Anti-factor IX(a) Monoclonal Antibody (SB 249417) to the Low Molecular Weight Heparin Enoxaparin In a Rat Model of Arterial Thrombosis by Toomey, John R, Blackburn, Michael N, Storer, Barbara L, Valocik, Richard E, Koster, Paul F, Feuerstein, Giora Z

“…A humanized inhibitory anti-factor IX(a) antibody (SB 249417) has been compared to enoxaparin (Lovenox) in a rat model of arterial thrombosis. Pretreatment of…”
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Activation of Caspase-3/Caspase-3-Like Activity in Rat Cardiomyocytes by an RGD Peptide, but not the GPIIb/IIIa Antagonist Lotrafiban by Erhardt, Joseph A., Ohlstein, Eliot H., Toomey, John R., Gabriel, Melanie A., Willette, Robert N., Yue, Tian-Li, Barone, Frank C., Parsons, Andrew A.

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Receptor-mediated Endocytosis of Coagulation Factor Xa Requires Cell Surface-bound Tissue Factor Pathway Inhibitor (∗) by Ho, Guyu, Toomey, John R., Broze, George J. Jr, Schwartz, Alan L.

“…Coagulation factor Xa is a plasma serine protease that catalyzes prothrombin to thrombin conversion, which, in turn, leads to the generation of the fibrin…”
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Localization of a factor VIII-inhibiting antibody epitope to a region between residues 338 and 362 of factor VIII heavy chain by Ware, J, Toomey, J R, Stafford, D W

“…We have used a recombinant DNA epitope library to localize the binding region of a factor VIII (FVIII) monoclonal antibody that neutralizes coagulant activity…”
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