Search Results - "Toole, Bryan P"

Hyaluronan-CD44 Interactions in Cancer: Paradoxes and Possibilities by TOOLE, Bryan P

“…Hyaluronan is a prominent component of the micro-environment in most malignant tumors and can be prognostic for tumor progression. Extensive experimental…”
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How, with whom and when: an overview of CD147-mediated regulatory networks influencing matrix metalloproteinase activity by Grass, G Daniel, Toole, Bryan P

“…Matrix metalloproteinases (MMPs) comprise a family of 23 zinc-dependent enzymes involved in various pathologic and physiologic processes. In cancer, MMPs…”
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Serglycin Proteoglycan Is Required for Multiple Myeloma Cell Adhesion, in Vivo Growth, and Vascularization by Purushothaman, Anurag, Toole, Bryan P.

“…Recently, it was discovered that serglycin, a hematopoietic cell proteoglycan, is the major proteoglycan expressed and constitutively secreted by multiple…”
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Hyaluronan: A constitutive regulator of chemoresistance and malignancy in cancer cells by Toole, Bryan P, Slomiany, Mark G

“…Abstract Hyaluronan not only is an important structural component of extracellular matrices but also interacts instructively with cells during embryonic…”
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CD147, CD44, and the Epidermal Growth Factor Receptor (EGFR) Signaling Pathway Cooperate to Regulate Breast Epithelial Cell Invasiveness by Grass, G. Daniel, Tolliver, Lauren B., Bratoeva, Momka, Toole, Bryan P.

“…The immunoglobulin superfamily glycoprotein CD147 (emmprin; basigin) is associated with an invasive phenotype in various types of cancers, including malignant…”
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Hyaluronan Constitutively Regulates Activation of Multiple Receptor Tyrosine Kinases in Epithelial and Carcinoma Cells by Misra, Suniti, Toole, Bryan P., Ghatak, Shibnath

“…Hyaluronan (HA) is enriched in the pericellular matrices of many malignant human tumors, and manipulations of HA interactions have strong effects on tumor…”
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Regulation of MDR1 Expression and Drug Resistance by a Positive Feedback Loop Involving Hyaluronan, Phosphoinositide 3-Kinase, and ErbB2 by Misra, Suniti, Ghatak, Shibnath, Toole, Bryan P.

“…Multidrug resistance is a potent barrier to effective, long term therapy in cancer patients. It is frequently attributed to enhanced expression of multidrug…”
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Roles of the multifunctional glycoprotein, emmprin (basigin; CD147), in tumour progression by Yan, Li, Zucker, Stanley, Toole, Bryan P

“…Emmprin (basigin;CD147) is a widely distributed cell surface glycoprotein that belongs to the Ig superfamily and is highly enriched on the surface of malignant…”
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Mesenchymal CD44 Expression Contributes to the Acquisition of an Activated Fibroblast Phenotype via TWIST Activation in the Tumor Microenvironment by SPAETH, Erika L, LABAFF, Adam M, TOOLE, Bryan P, KLOPP, Ann, ANDREEFF, Michael, MARINI, Frank C

“…Tumor-stroma interactions play a crucial role in cancer progression by eliciting factors that promote proliferative, angiogenic, and invasive supports to the…”
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Hyaluronan Constitutively Regulates ErbB2 Phosphorylation and Signaling Complex Formation in Carcinoma Cells by Ghatak, Shibnath, Misra, Suniti, Toole, Bryan P.

“…Hyaluronan is enriched in many types of human cancers, and manipulations of hyaluronan expression or interactions have a major influence on tumor progression…”
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Conditional inactivation of Has2 reveals a crucial role for hyaluronan in skeletal growth, patterning, chondrocyte maturation and joint formation in the developing limb by Matsumoto, Kazu, Li, Yingcui, Jakuba, Caroline, Sugiyama, Yoshinori, Sayo, Tetsuya, Okuno, Misako, Dealy, Caroline N, Toole, Bryan P, Takeda, Junji, Yamaguchi, Yu, Kosher, Robert A

“…The glycosaminoglycan hyaluronan (HA) is a structural component of extracellular matrices and also interacts with cell surface receptors to directly influence…”
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Hyaluronan Oligosaccharides Inhibit Anchorage-independent Growth of Tumor Cells by Suppressing the Phosphoinositide 3-Kinase/Akt Cell Survival Pathway by Ghatak, Shibnath, Misra, Suniti, Toole, Bryan P.

“…Hyaluronan oligosaccharides (molecular weight: ∼2.5 × 103) inhibit growth of several types of tumors in vivo. In vitro, the oligomers inhibit…”
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Regulation of invadopodia formation and activity by CD147 by Grass, G Daniel, Bratoeva, Momka, Toole, Bryan P

“…A defining feature of malignant tumor progression is cellular penetration through the basement membrane and interstitial matrices that separate various…”
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Hyaluronan, CD44, and Emmprin Regulate Lactate Efflux and Membrane Localization of Monocarboxylate Transporters in Human Breast Carcinoma Cells by SLOMIANY, Mark G, DANIEL GRASS, G, ROBERTSON, Angela D, YANG, Xiao Y, MARIA, Bernard L, BEESON, Craig, TOOLE, Bryan P

“…Interactions of hyaluronan with CD44 in tumor cells play important cooperative roles in various aspects of malignancy and drug resistance. Emmprin (CD147;…”
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Inhibition of Functional Hyaluronan-CD44 Interactions in CD133-positive Primary Human Ovarian Carcinoma Cells by Small Hyaluronan Oligosaccharides by SLOMIANY, Mark G, LU DAI, TOLLIVER, Lauren B, DANIEL GRASS, G, YIPING ZENG, TOOLE, Bryan P

“…Purpose: CD44 is one of the most common markers used for identification of highly tumorigenic subpopulations of human carcinoma cells, but little is known…”
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Hyaluronan-cell interactions in cancer and vascular disease by Toole, Bryan P, Wight, Thomas N, Tammi, Markku I

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Regulation of Multidrug Resistance in Cancer Cells by Hyaluronan by Misra, Suniti, Ghatak, Shibnath, Zoltan-Jones, Alexandra, Toole, Bryan P.

“…Multidrug resistance in cancer cells is often due to ATP-dependent efflux pumps, but is also linked to alterations in cell survival and apoptotic signaling…”
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BMP-2 induces versican and hyaluronan that contribute to post-EMT AV cushion cell migration by Inai, Kei, Burnside, Jessica L, Hoffman, Stanley, Toole, Bryan P, Sugi, Yukiko

“…Distal outgrowth and maturation of mesenchymalized endocardial cushions are critical morphogenetic events during post-EMT atrioventricular (AV) valvuloseptal…”
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Elevated Hyaluronan Production Induces Mesenchymal and Transformed Properties in Epithelial Cells by Zoltan-Jones, Alexandra, Huang, Lei, Ghatak, Shibnath, Toole, Bryan P.

“…During carcinoma progression, tumor cells often undergo changes similar (but not identical) to epithelialmesenchymal transitions in embryonic development. In…”
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Chronic activation of the prostaglandin receptor EP4 promotes hyaluronan-mediated neointimal formation in the ductus arteriosus by Yokoyama, Utako, Minamisawa, Susumu, Quan, Hong, Ghatak, Shibnath, Akaike, Toru, Segi-Nishida, Eri, Iwasaki, Shiho, Iwamoto, Mari, Misra, Suniti, Tamura, Kouichi, Hori, Hideaki, Yokota, Shumpei, Toole, Bryan P, Sugimoto, Yukihiko, Ishikawa, Yoshihiro

“…PGE, a potent vasodilator, plays a primary role in maintaining the patency of the ductus arteriosus (DA). Genetic disruption of the PGE-specific receptor EP4,…”
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