Search Results - "Tony Ip, Y."

Pharmacological blockade of TEAD–YAP reveals its therapeutic limitation in cancer cells by Sun, Yang, Hu, Lu, Tao, Zhipeng, Jarugumilli, Gopala K., Erb, Hannah, Singh, Alka, Li, Qi, Cotton, Jennifer L., Greninger, Patricia, Egan, Regina K., Tony Ip, Y., Benes, Cyril H., Che, Jianwei, Mao, Junhao, Wu, Xu

“…Targeting TEAD autopalmitoylation has been proposed as a therapeutic approach for YAP-dependent cancers. Here we show that TEAD palmitoylation inhibitor…”
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Toll family members bind multiple Spätzle proteins and activate antimicrobial peptide gene expression in Drosophila by Chowdhury, Munmun, Li, Chun-Feng, He, Zhen, Lu, Yuzhen, Liu, Xu-Sheng, Wang, Yu-Feng, Ip, Y. Tony, Strand, Michael R., Yu, Xiao-Qiang

“…The Toll signaling pathway in Drosophila melanogaster regulates several immune-related functions, including the expression of antimicrobial peptide (AMP)…”
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Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription by Li, Qi, Sun, Yang, Jarugumilli, Gopala K., Liu, Shun, Dang, Kyvan, Cotton, Jennifer L., Xiol, Jordi, Chan, Pui Yee, DeRan, Michael, Ma, Lifang, Li, Rui, Zhu, Lihua J., Li, Joyce H., Leiter, Andrew B., Ip, Y. Tony, Camargo, Fernando D., Luo, Xuelian, Johnson, Randy L., Wu, Xu, Mao, Junhao

“…Intestinal homeostasis is tightly regulated by complex yet poorly understood signaling networks. Here, we demonstrate that Lats1/2, the core Hippo kinases, are…”
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Hippo signaling regulates Drosophila intestine stem cell proliferation through multiple pathways by Ren, Fangfang, Wang, Bing, Yue, Tao, Yun, Eun-Young, Ip, Y. Tony, Jiang, Jin, Levine, Michael

“…Intestinal stem cells (ISCs) in the Drosophila adult midgut are essential for maintaining tissue homeostasis and replenishing lost cells in response to tissue…”
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Tuberous sclerosis complex and Myc coordinate the growth and division of Drosophila intestinal stem cells by Amcheslavsky, Alla, Ito, Naoto, Jiang, Jin, Ip, Y Tony

“…Intestinal stem cells (ISCs) in the adult Drosophila melanogaster midgut can respond to damage and support repair. We demonstrate in this paper that the…”
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Enteroendocrine cells support intestinal stem-cell-mediated homeostasis in Drosophila by Amcheslavsky, Alla, Song, Wei, Li, Qi, Nie, Yingchao, Bragatto, Ivan, Ferrandon, Dominique, Perrimon, Norbert, Ip, Y Tony

“…Intestinal stem cells in the adult Drosophila midgut are regulated by growth factors produced from the surrounding niche cells including enterocytes and…”
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The Conserved Misshapen-Warts-Yorkie Pathway Acts in Enteroblasts to Regulate Intestinal Stem Cells in Drosophila by Li, Qi, Li, Shuangxi, Mana-Capelli, Sebastian, Roth Flach, Rachel J., Danai, Laura V., Amcheslavsky, Alla, Nie, Yingchao, Kaneko, Satoshi, Yao, Xiaohao, Chen, Xiaochu, Cotton, Jennifer L., Mao, Junhao, McCollum, Dannel, Jiang, Jin, Czech, Michael P., Xu, Lan, Ip, Y. Tony

“…Similar to the mammalian intestine, the Drosophila adult midgut has resident stem cells that support growth and regeneration. How the niche regulates…”
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Pathogenic stimulation of intestinal stem cell response in drosophila by Chatterjee, Madhurima, Ip, Y. Tony

“…Stem cell‐mediated tissue repair is a promising approach for many diseases. Mammalian intestine is an actively regenerating tissue such that epithelial cells…”
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Ingestion of Food Particles Regulates the Mechanosensing Misshapen-Yorkie Pathway in Drosophila Intestinal Growth by Li, Qi, Nirala, Niraj K., Nie, Yingchao, Chen, Hsi-Ju, Ostroff, Gary, Mao, Junhao, Wang, Qi, Xu, Lan, Ip, Y. Tony

“…The intestinal epithelium has a high cell turnover rate and is an excellent system to study stem cell-mediated adaptive growth. In the Drosophila midgut, the…”
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Toll and IMD Pathways Synergistically Activate an Innate Immune Response in Drosophila melanogaster by Tanji, Takahiro, Hu, Xiaodi, Weber, Alexander N. R., Ip, Y. Tony

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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YAP/TAZ Activation Drives Uveal Melanoma Initiation and Progression by Li, Huapeng, Li, Qi, Dang, Kyvan, Ma, Shan, Cotton, Jennifer L., Yang, Sun, Zhu, Lihua J., Deng, April C., Ip, Y. Tony, Johnson, Randy L., Wu, Xu, Punzo, Claudio, Mao, Junhao

“…Uveal melanoma (UM), the most common ocular malignancy, is characterized by GNAQ/11 mutations. Hippo/YAP and Ras/mitogen-activated protein kinase (MAPK) emerge…”
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Gudu, an Armadillo repeat-containing protein, is required for spermatogenesis in Drosophila by Cheng, Wei, Ip, Y. Tony, Xu, Zuoshang

“…The Drosophila annotated gene CG5155 encodes a protein that contains 10 Armadillo-repeats and has an unknown function. To fill this gap, we performed…”
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Regulators of the Toll and Imd pathways in the Drosophila innate immune response by Tanji, Takahiro, Ip, Y. Tony

“…The innate immune response is the first line of defense against microbial infections in both insects and mammals. Systematic analysis of the innate immune…”
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Drosophila Myc integrates multiple signaling pathways to regulate intestinal stem cell proliferation during midgut regeneration by Ren, Fangfang, Shi, Qing, Chen, Yongbin, Jiang, Alice, Ip, Y Tony, Jiang, Huaqi, Jiang, Jin

“…Intestinal stem cells （ISCs） in the Drosophila adult midgut are essential for maintaining tissue homeostasis, and their proliferation and differentiation speed…”
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Toll-9 interacts with Toll-1 to mediate a feedback loop during apoptosis-induced proliferation in Drosophila by Shields, Alicia, Amcheslavsky, Alla, Brown, Elizabeth, Lee, Tom V., Nie, Yingchao, Tanji, Takahiro, Ip, Y. Tony, Bergmann, Andreas

“…Drosophila Toll-1 and all mammalian Toll-like receptors regulate innate immunity. However, the functions of the remaining eight Toll-related proteins in…”
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Recycling Endosomes in Mature Epithelia Restrain Tumorigenic Signaling by D'Agostino, Luca, Nie, Yingchao, Goswami, Sayantani, Tong, Kevin, Yu, Shiyan, Bandyopadhyay, Sheila, Flores, Juan, Zhang, Xiao, Balasubramanian, Iyshwarya, Joseph, Ivor, Sakamori, Ryotaro, Farrell, Victoria, Li, Qi, Yang, Chung S, Gao, Bin, Ferraris, Ronaldo P, Yehia, Ghassan, Bonder, Edward M, Goldenring, James R, Verzi, Michael P, Zhang, Lanjing, Ip, Y Tony, Gao, Nan

“…The effects of polarized membrane trafficking in mature epithelial tissue on cell growth and cancer progression have not been fully explored . A majority of…”
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How Toll Met Hippo by Nie, Yingchao, Ip, Y. Tony

“…Toll and Hippo are two seemingly disparate pathways that regulate innate immunity and tissue growth, respectively. Reporting recently in Cell, Liu et al…”
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The Misshapen subfamily of Ste20 kinases regulate proliferation in the aging mammalian intestinal epithelium by Li, Qi, Nirala, Niraj K., Chen, Hsi‐Ju, Nie, Yingchao, Wang, Wei, Zhang, Biliang, Czech, Michael P., Wang, Qi, Xu, Lan, Mao, Junhao, Ip, Y. Tony

“…The intestinal epithelium has a high rate of cell turn over and is an excellent system to study stem cell‐mediated tissue homeostasis. The Misshapen subfamily…”
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The Snakeskin-Mesh Complex of Smooth Septate Junction Restricts Yorkie to Regulate Intestinal Homeostasis in Drosophila by Chen, Hsi-Ju, Li, Qi, Nirala, Niraj K., Ip, Y. Tony

“…Tight junctions in mammals and septate junctions in insects are essential for epithelial integrity. We show here that, in the Drosophila intestine, smooth…”
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Functional analysis of Toll-related genes in Drosophila by Yagi, Yoshimasa, Nishida, Yasuyoshi, Ip, Y. Tony

“…The Drosophila genome encodes a total of nine Toll and related proteins. The immune and developmental functions of Toll and 18Wheeler (18W) have been analyzed…”
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