Myeloperoxidase enzyme and Ferric-reducing antioxidant power concentrations in lean and obese dogs

Myeloperoxidase enzyme and Ferric-reducing antioxidant power concentrations in lean and obese dogs

The study aimed to assess plasma Myeloperoxidase enzyme (MPO) and Ferric-reducing antioxidant power (FRAP) in obese dogs and compare them with ideal body weight dogs. Thirty-two dogs were distributed into two groups according to a 9-point body condition score (BCS), as follows: Control group (n = 16...

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Published in:Veterinary research communications Vol. 47; no. 2; pp. 1007 - 1013
Main Authors: Paulo, Rodrigo Rodrigues, Galvão, Victoria Elizabeth, da Silva, Gustavo Gomes, Porto, Laura Pereira, Tonossu, Juliana Mayumi, Gandolfi, Maira Beatriz, Guimarães-Okamoto, Priscylla Tatiana Chalfun, Takahira, Regina Kiomi, Rahal, Sheila Canevese, Melchert, Alessandra
Format: Journal Article
Language:English
Published: Dordrecht Springer Netherlands 01-06-2023
Springer Nature B.V
Subjects:
Animals
Antioxidants
Biomedical and Life Sciences
Blood pressure
Body Weight
Brief Report
Cholesterol
Dog Diseases
Dogs
Enzymes
Inflammation
Leukocyte Count - veterinary
Leukocytes (neutrophilic)
Life Sciences
Neutrophils
Obesity
Obesity - veterinary
Peroxidase
Triglycerides
Veterinary Medicine/Veterinary Science
Zoology
Obesity
Ferric-reducing antioxidant power
Body condition score
Myeloperoxidase enzyme
Dogs
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Summary:The study aimed to assess plasma Myeloperoxidase enzyme (MPO) and Ferric-reducing antioxidant power (FRAP) in obese dogs and compare them with ideal body weight dogs. Thirty-two dogs were distributed into two groups according to a 9-point body condition score (BCS), as follows: Control group (n = 16), dogs with a BCS of 4 or 5; Obese group (n = 16), dogs with a BCS of 8 or 9. Plasma MPO and FRAP assays, neutrophil count, lipid profile (cholesterol and triglycerides), and systolic blood pressure (SBP) were evaluated in both groups. The duration of obesity was defined based on history. The obese group showed higher values for body weight, BCS, SBP, neutrophil count, triglycerides, and MPO than the Control group. A positive correlation was observed between MPO concentrations and BCS and body weight. FRAP concentrations showed a positive correlation with the duration of obesity. The results suggested that an inflammatory state caused by obesity may promote increased neutrophil count and MPO concentrations, besides the positive correlation between MPO with BCS and body weight. The obesity in dogs promoted slight active MPO elevation, influenced by body weight, BCS, and neutrophil count. The FRAP assay did not show the expected reduction and, therefore, needs further investigation.
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ISSN:0165-7380
1573-7446
DOI:10.1007/s11259-022-10059-w