Search Results - "Tonnelle, Cecile"

The role of Ikaros in human erythroid differentiation by Dijon, Marilyne, Bardin, Florence, Murati, Anne, Batoz, Michèle, Chabannon, Christian, Tonnelle, Cécile

“…Ikaros—a factor that positively or negatively controls gene transcription—is active in murine adult erythroid cells, and involved in fetal to adult globin…”
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Stage specific over-expression of the dominant negative Ikaros 6 reveals distinct role of Ikaros throughout human B-cell differentiation by Tonnelle, Cécile, Dijon, Marilyne, Moreau, Thomas, Garulli, Céline, Bardin, Florence, Chabannon, Christian

“…Ikaros is a transcription factor that acts both as an activator and as an inhibitor of gene expression in several hematopoietic lineages. Ikaros functions in…”
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Potential application of gene therapy to X-linked agammaglobulinemia by Moreau, Thomas, Calmels, Boris, Barlogis, Vincent, Michel, Gérard, Tonnelle, Cécile, Chabannon, Christian

“…X-linked agammaglobulinemia (XLA), or Bruton's disease, is the most common human primary humoral immunodeficiency. XLA is caused by mutations of the Bruton's…”
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Ikaros and erythropoiesis by Dijon, Marilyne, Chabannon, Christian, Tonnelle, Cécile

“…Mostly studied in murine models, Ikaros--a factor that positively or negatively controls gene transcription--was first described as essential to lymphopoiesis…”
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Hematopoietic engraftment of XLA bone marrow CD34+ cells in NOG/SCID mice by Moreau, Thomas, Bardin, Florence, Barlogis, Vincent, Deist, Françoise Le, Chabannon, Christian, MD, PhD, Tonnelle, Cécile

“…Background aims X-linked agammaglobulinemia (XLA) is a rare primary immunodeficiency associated with mutations of the BTK (Bruton agammaglobulinemia tyrosine…”
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Age‐related changes in human hematopoietic stem/progenitor cells by Kuranda, Klaudia, Vargaftig, Jacques, de la Rochere, Philippe, Dosquet, Christine, Charron, Dominique, Bardin, Florence, Tonnelle, Cecile, Bonnet, Dominique, Goodhardt, Michele

“…Summary Adult stem cells are critical for maintaining cellular homeostasis throughout life, yet the effects of age on their regenerative capacity are poorly…”
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CD99 expressed on human mobilized peripheral blood CD34+ cells is involved in transendothelial migration by Imbert, Anne-Marie, Belaaloui, Ghania, Bardin, Florence, Tonnelle, Cecile, Lopez, Marc, Chabannon, Christian

“…Hematopoietic progenitor cell trafficking is an important phenomenon throughout life. It is thought to occur in sequential steps, similar to what has been…”
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Forced expression of the Ikaros 6 isoform in human placental blood CD34+ cells impairs their ability to differentiate toward the B-lymphoid lineage by Tonnelle, Cécile, Bardin, Florence, Maroc, Christine, Imbert, Anne-Marie, Campa, Fanny, Dalloul, Ali, Schmitt, Christian, Chabannon, Christian

“…Studies in mice suggest that the Ikaros (Ik) gene encodes several isoforms and is a critical regulator of hematolymphoid differentiation. Little is known on…”
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Age-related changes in human hematopoietic stem/progenitor cells: Aging of human HSC by Kuranda, Klaudia, Vargaftig, Jacques, de la Rochere, Philippe, Dosquet, Christine, Charron, Dominique, Bardin, Florence, Tonnelle, Cecile, Bonnet, Dominique, Goodhardt, Michele

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855. B-Specific Lentiviral Vectors Expressing Btk: Tools for a Gene Therapy of X-Linked Agammaglobulinemia by Moreau, Thomas, Barlogis, Vincent, Chabannon, Christian, Tonnelle, Cecile

“…X-linked agammaglobulinemia (XLA) is the most common human primary humoral immunodeficiency. XLA is caused by mutations of the Bruton's tyrosine kinase (Btk),…”
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Recombination Occurs in Lentiviral Vectors Designed To Express Both EGFP and EYFP in Human Hematopoietic Cells by Dijon, Marilyne, Torne-Celer, Caroline, Tonnelle, Cecile, Chabannon, Christian

“…Recombinant lentiviruses are widely used vectors for in vitro and in vivo long-term gene transfer. Many of the initial gene transfer studies were conducted…”
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Restriction of Transgene Expression to the B-lymphoid Progeny of Human lentivirally Transduced CD34 Cells by Moreau, Thomas, Bardin, Florence, Imbert, Jean, Chabannon, Christian, Tonnelle, Cécile

“…Development of gene transfer strategies will necessitate improved efficiency and control of transduction and transgene expression. We here provide evidence…”
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Cell surface expression of class II histocompatibility antigens occurs in the absence of the invariant chain by SEKALY, R. P, TONNELLE, C, STRUBIN, M, MACH, B, LONG, E. O

“…The invariant chain is a glycoprotein transiently associated with the alpha and beta subunits of class II antigens of the major histocompatibility complex…”
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Human thymic B cells largely overexpress the VH4 Ig gene family. A possible role in the control of tolerance in situ? by Tonnelle, C, D'Ercole, C, Depraetere, V, Métras, D, Boubli, L, Fougereau, M

“…Human thymus contains a small population of B cells, a fraction of which expresses CD2 and/or CD5, as revealed by FACS analysis. Human thymic B cells enriched…”
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Human FLT3/FLK2 Gene: cDNA Cloning and Expression in Hematopoietic Cells by Rosnet, Olivier, Schiff, Claudine, Pébusque, Marie-Josèphe, Marchetto, Sylvie, Tonnelle, Cécile, Toiron, Yves, Birg, Françoise, Birnbaum, Daniel

“…The human FLT3 cDNA was cloned from a pre-B-cell line and characterized. The deduced amino acid sequence shows that FLT3 codes for a receptor-type tyrosine…”
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Antigen Presentation to HLA Class II-Restricted Measles Virus-Specific T-Cell Clones Can Occur in the Absence of the Invariant Chain by Sekaly, Rafick P., Jacobson, Steven, Richert, John R., Tonnelle, Cecile, McFarland, Henry F., Long, Eric O.

“…A human fibroblast line expressing HLA-DR1 antigen on its surface was generated by transfection with DRα and DRβ cDNAs. Expression of the invariant chain gene…”
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IGM kappa/lambda EBV human B cell clone: an early step of differentiation of fetal B cells or a distinct B lineage? by Cuisinier, A M, Fumoux, F, Fougereau, M, Tonnelle, C

“…In agreement with the clonal theory, one B lymphocyte synthesizes one antibody due to allelic and isotypic exclusion. We analyzed an EBV B-cell clone, E29.1,…”
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Ikaros Gene Expression and Leukemia by Tonnelle, Cécile, Calmels, Boris, Maroc, Christine, Gabert, Jean, Chabannon, Christian

“…The Ikaros (Ik) protein, or LyF1, was initially described as a protein binding to regulatory sequences of a number of genes expressed in murine lymphoid cells…”
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Overexpression of dominant-negative Ikaros 6 protein is restricted to a subset of B common adult acute lymphoblastic leukemias that express high levels of the CD34 antigen by Tonnelle, Cécile, Imbert, Marie-Christine, Sainty, Danielle, Granjeaud, Samuel, N'Guyen, Catherine, Chabannon, Christian

“…Ikaros is a critical regulator of hematopoiesis. Its effects result in part from the balance between the isoforms that are produced by differential splicing of…”
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The VDJ repertoire expressed in human preB cells reflects the selection of bona fide heavy chains by Milili, M, Schiff, C, Fougereau, M, Tonnelle, C

“…In early steps of B cell differentiation, mu chains are transiently expressed in association with a surrogate light chain (psi L) composed of the lambda-like…”
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