Search Results - "Tonne, Jason M"

Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue by Schafer, Marissa J, White, Thomas A, Evans, Glenda, Tonne, Jason M, Verzosa, Grace C, Stout, Michael B, Mazula, Daniel L, Palmer, Allyson K, Baker, Darren J, Jensen, Michael D, Torbenson, Michael S, Miller, Jordan D, Ikeda, Yasuhiro, Tchkonia, Tamara, van Deursen, Jan M, Kirkland, James L, LeBrasseur, Nathan K

“…Considerable evidence implicates cellular senescence in the biology of aging and chronic disease. Diet and exercise are determinants of healthy aging; however,…”
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APOBEC3B-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapy by Driscoll, Christopher B., Schuelke, Matthew R., Kottke, Timothy, Thompson, Jill M., Wongthida, Phonphimon, Tonne, Jason M., Huff, Amanda L., Miller, Amber, Shim, Kevin G., Molan, Amy, Wetmore, Cynthia, Selby, Peter, Samson, Adel, Harrington, Kevin, Pandha, Hardev, Melcher, Alan, Pulido, Jose S., Harris, Reuben, Evgin, Laura, Vile, Richard G.

“…APOBEC3B, an anti-viral cytidine deaminase which induces DNA mutations, has been implicated as a mediator of cancer evolution and therapeutic resistance…”
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Murine leukemia virus uses NXF1 for nuclear export of spliced and unspliced viral transcripts by Sakuma, Toshie, Davila, Jaime I, Malcolm, Jessica A, Kocher, Jean-Pierre A, Tonne, Jason M, Ikeda, Yasuhiro

“…Intron-containing mRNAs are subject to restricted nuclear export in higher eukaryotes. Retroviral replication requires the nucleocytoplasmic transport of both…”
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Generation of a Tumor-Specific Chemokine Gradient Using Oncolytic Vesicular Stomatitis Virus Encoding CXCL9 by Eckert, Elizabeth C., Nace, Rebecca A., Tonne, Jason M., Evgin, Laura, Vile, Richard G., Russell, Stephen J.

“…Genetically modified vesicular stomatitis virus (VSV) is an attractive agent for cancer treatment due to rapid intratumoral replication and observed clinical…”
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Long-Term Cardiac pro-B-Type Natriuretic Peptide Gene Delivery Prevents the Development of Hypertensive Heart Disease in Spontaneously Hypertensive Rats by CATALIOTTI, Alessandro, TONNE, Jason M, BURNETT, John C, IKEDA, Yasuhiro, BELLAVIA, Diego, MARTIN, Fernando L, OEHLER, Elise A, HARDERS, Gerald E, CAMPBELL, Jarryd M, PENG, Kaw-Whye, RUSSELL, Stephen J, MALATINO, Lorenzo S

“…Diastolic dysfunction associated with high blood pressure (BP) leads to cardiac remodeling and fibrosis and progression to congestive heart failure. B-type…”
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Impaired β-cell glucokinase as an underlying mechanism in diet-induced diabetes by Lu, Brian, Kurmi, Kiran, Munoz-Gomez, Miguel, Jacobus Ambuludi, Egon J, Tonne, Jason M, Rakshit, Kuntol, Hitosugi, Taro, Kudva, Yogish C, Matveyenko, Aleksey V, Ikeda, Yasuhiro

“…High-fat diet (HFD)-fed mouse models have been widely used to study early type 2 diabetes. Decreased β-cell glucokinase (GCK) expression has been observed in…”
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Secretion of Glycosylated Pro―B-Type Natriuretic Peptide from Normal Cardiomyocytes by TONNE, Jason M, CAMPBELL, Jarryd M, CATALIOTTI, Alessandro, OHMINE, Seiga, THATAVA, Tayaramma, SAKUMA, Toshie, MACHERET, Fima, HUNTLEY, Brenda K, BURNETT, John C, IKEDA, Yasuhiro

“…B-type natriuretic peptide (BNP), a key cardiac hormone in cardiorenal homeostasis, is produced as a 108 amino acid prohormone, proBNP1-108, which is converted…”
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A phase I oncolytic virus trial with vesicular stomatitis virus expressing human interferon beta and tyrosinase related protein 1 administered intratumorally and intravenously in uveal melanoma: safety, efficacy, and T cell responses by Smith, Katherine E R, Peng, Kah-Whye, Pulido, Jose S, Weisbrod, Adam J, Strand, Carrie A, Allred, Jacob B, Newsom, Alysha N, Zhang, Lianwen, Packiriswamy, Nandakumar, Kottke, Timothy, Tonne, Jason M, Moore, Madelyn, Montane, Heather N, Kottschade, Lisa A, McWilliams, Robert R, Dudek, Arkadiusz Z, Yan, Yiyi, Dimou, Anastasios, Markovic, Svetomir N, Federspiel, Mark J, Vile, Richard G, Dronca, Roxana S, Block, Matthew S

“…Metastatic uveal melanoma (MUM) has a poor prognosis and treatment options are limited. These patients do not typically experience durable responses to immune…”
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Global gene expression profiling of pancreatic islets in mice during streptozotocin-induced β-cell damage and pancreatic Glp-1 gene therapy by Tonne, Jason M, Sakuma, Toshie, Deeds, Michael C, Munoz-Gomez, Miguel, Barry, Michael A, Kudva, Yogish C, Ikeda, Yasuhiro

“…Streptozotocin (STZ), a glucosamine-nitrosourea compound, has potent genotoxic effects on pancreatic β-cells and is frequently used to induce diabetes in…”
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Divergent susceptibilities to AAV-SaCas9-gRNA vector-mediated genome-editing in a single-cell-derived cell population by Morsy, Salma G, Tonne, Jason M, Zhu, Yaxi, Lu, Brian, Budzik, Karol, Krempski, James W, Ali, Sherine A, El-Feky, Mohamed A, Ikeda, Yasuhiro

“…Recombinant adeno-associated virus (AAV)-based vectors are characterized by their robust and safe transgene delivery. The CRISPR/Cas9 and guide RNA (gRNA)…”
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Tumor‐Free Transplantation of Patient‐Derived Induced Pluripotent Stem Cell Progeny for Customized Islet Regeneration by El Khatib, Moustafa M., Ohmine, Seiga, Jacobus, Egon J., Tonne, Jason M., Morsy, Salma G., Holditch, Sara J., Schreiber, Claire A., Uetsuka, Koji, Fusaki, Noemi, Wigle, Dennis A., Terzic, Andre, Kudva, Yogish C., Ikeda, Yasuhiro

“…Transplantation of progenitors from induced pluripotent stem cells reprogrammed by lentiviral vectors led to the formation of invasive teratocarcinoma‐like…”
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Hyperinsulinemic hypoglycemia subtype glucokinase V91L mutant induces necrosis in β-cells via ATP depletion by Lu, Brian, Tonne, Jason M, Munoz-Gomez, Miguel, Ikeda, Yasuhiro

“…Hyperinsulinemic hypoglycemia subtype glucokinase (GCK-HH) is caused by an activating mutation in glucokinase (GCK) and has been shown to increase β-cell…”
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Targeted Derivation of Organotypic Glucose- and GLP-1-Responsive β Cells Prior to Transplantation into Diabetic Recipients by Zhu, Yaxi, Tonne, Jason M., Liu, Qian, Schreiber, Claire A., Zhou, Zhiguang, Rakshit, Kuntol, Matveyenko, Aleksey V., Terzic, Andre, Wigle, Dennis, Kudva, Yogish C., Ikeda, Yasuhiro

“…Generation of functional β cells from pluripotent sources would accelerate diagnostic and therapeutic applications for diabetes research and therapy. However,…”
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Murine leukemia virus uses TREX components for efficient nuclear export of unspliced viral transcripts by Sakuma, Toshie, Tonne, Jason M, Ikeda, Yasuhiro

“…Previously we reported that nuclear export of both unspliced and spliced murine leukemia virus (MLV) transcripts depends on the nuclear export factor (NXF1)…”
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Early Events in Retrovirus XMRV Infection of the Wild-Derived Mouse Mus pahari by SAKUMA, Toshie, TONNE, Jason M, SQUILLACE, Karen A, OHMINE, Seiga, THATAVA, Tayaramma, PENG, Kah-Whye, BARRY, Michael A, IKEDA, Yasuhiro

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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No evidence of XMRV in prostate cancer cohorts in the Midwestern United States by Sakuma, Toshie, Hué, Stéphane, Squillace, Karen A, Tonne, Jason M, Blackburn, Patrick R, Ohmine, Seiga, Thatava, Tayaramma, Towers, Greg J, Ikeda, Yasuhiro

“…Xenotropic murine leukemia virus (MLV)-related virus (XMRV) was initially identified in prostate cancer (PCa) tissue, particularly in the prostatic stromal…”
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Long-term infection and vertical transmission of a gammaretrovirus in a foreign host species by Sakuma, Toshie, Tonne, Jason M, Malcolm, Jessica A, Thatava, Tayaramma, Ohmine, Seiga, Peng, Kah-Whye, Ikeda, Yasuhiro

“…Increasing evidence has indicated natural transspecies transmission of gammaretroviruses; however, viral-host interactions after initial xeno-exposure remain…”
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B-Type Natriuretic Peptide Deletion Leads to Progressive Hypertension, Associated Organ Damage, and Reduced Survival: Novel Model for Human Hypertension by Holditch, Sara J, Schreiber, Claire A, Nini, Ryan, Tonne, Jason M, Peng, Kah-Whye, Geurts, Aron, Jacob, Howard J, Burnett, John C, Cataliotti, Alessandro, Ikeda, Yasuhiro

“…Altered myocardial structure and function, secondary to chronically elevated blood pressure, are leading causes of heart failure and death. B-type natriuretic…”
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Smoldering oncolysis by foamy virus carrying CD19 as a CAR target escapes CAR T detection by genomic modification by Tonne, Jason M, Budzik, Karol, Carrasco, Talia Fernandez, Ebbert, Landon, Thompson, Jill, Nace, Rebecca, Kendall, Benjamin, Diaz, Rosa M, Russell, Stephen J, Vile, Richard G

“…Chimeric antigen receptor (CAR) T cells have had limited success against solid tumors. Here, we used an oncolytic foamy virus (oFV) to display a model CAR…”
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Beta cell regeneration after single-round immunological destruction in a mouse model by Tonne, Jason M., Sakuma, Toshie, Munoz-Gomez, Miguel, El Khatib, Moustafa, Barry, Michael A., Kudva, Yogish C., Ikeda, Yasuhiro

“…Aims/hypothesis Achieving a better understanding of beta cell regeneration after immunological destruction is crucial for the development of immunotherapy…”
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