Search Results - "Tonne, Jason"

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    Murine leukemia virus uses NXF1 for nuclear export of spliced and unspliced viral transcripts by Sakuma, Toshie, Davila, Jaime I, Malcolm, Jessica A, Kocher, Jean-Pierre A, Tonne, Jason M, Ikeda, Yasuhiro

    Published in Journal of virology (01-04-2014)
    “…Intron-containing mRNAs are subject to restricted nuclear export in higher eukaryotes. Retroviral replication requires the nucleocytoplasmic transport of both…”
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    Journal Article
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    Generation of a Tumor-Specific Chemokine Gradient Using Oncolytic Vesicular Stomatitis Virus Encoding CXCL9 by Eckert, Elizabeth C., Nace, Rebecca A., Tonne, Jason M., Evgin, Laura, Vile, Richard G., Russell, Stephen J.

    Published in Molecular therapy. Oncolytics (27-03-2020)
    “…Genetically modified vesicular stomatitis virus (VSV) is an attractive agent for cancer treatment due to rapid intratumoral replication and observed clinical…”
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    Impaired β-cell glucokinase as an underlying mechanism in diet-induced diabetes by Lu, Brian, Kurmi, Kiran, Munoz-Gomez, Miguel, Jacobus Ambuludi, Egon J, Tonne, Jason M, Rakshit, Kuntol, Hitosugi, Taro, Kudva, Yogish C, Matveyenko, Aleksey V, Ikeda, Yasuhiro

    Published in Disease models & mechanisms (01-06-2018)
    “…High-fat diet (HFD)-fed mouse models have been widely used to study early type 2 diabetes. Decreased β-cell glucokinase (GCK) expression has been observed in…”
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    APOBEC3B expression in 293T viral producer cells drives mutations in chimeric antigen receptors and reduces CAR T cell efficacy by Swanson, Jack, Tonne, Jason, Sangsuwannukul, Thanich, Thompson, Jill, Kendall, Benjamin, Liseth, Olivia, Metko, Muriel, Vile, Richard

    Published in Molecular Therapy: Oncology (19-12-2024)
    “…Chimeric antigen receptor (CAR) T cells are a clinically approved therapy for blood cancers. To produce clinical-grade CAR T cells, a retroviral or lentiviral…”
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    Journal Article
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    Smoldering oncolysis by foamy virus carrying CD19 as a CAR target escapes CAR T detection by genomic modification by Tonne, Jason M, Budzik, Karol, Carrasco, Talia Fernandez, Ebbert, Landon, Thompson, Jill, Nace, Rebecca, Kendall, Benjamin, Diaz, Rosa M, Russell, Stephen J, Vile, Richard G

    Published in Molecular Therapy: Oncology (19-09-2024)
    “…Chimeric antigen receptor (CAR) T cells have had limited success against solid tumors. Here, we used an oncolytic foamy virus (oFV) to display a model CAR…”
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    Journal Article
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    Secretion of Glycosylated Pro―B-Type Natriuretic Peptide from Normal Cardiomyocytes by TONNE, Jason M, CAMPBELL, Jarryd M, CATALIOTTI, Alessandro, OHMINE, Seiga, THATAVA, Tayaramma, SAKUMA, Toshie, MACHERET, Fima, HUNTLEY, Brenda K, BURNETT, John C, IKEDA, Yasuhiro

    Published in Clinical chemistry (Baltimore, Md.) (01-06-2011)
    “…B-type natriuretic peptide (BNP), a key cardiac hormone in cardiorenal homeostasis, is produced as a 108 amino acid prohormone, proBNP1-108, which is converted…”
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    No evidence of XMRV in prostate cancer cohorts in the Midwestern United States by Sakuma, Toshie, Hué, Stéphane, Squillace, Karen A, Tonne, Jason M, Blackburn, Patrick R, Ohmine, Seiga, Thatava, Tayaramma, Towers, Greg J, Ikeda, Yasuhiro

    Published in Retrovirology (29-03-2011)
    “…Xenotropic murine leukemia virus (MLV)-related virus (XMRV) was initially identified in prostate cancer (PCa) tissue, particularly in the prostatic stromal…”
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    Global gene expression profiling of pancreatic islets in mice during streptozotocin-induced β-cell damage and pancreatic Glp-1 gene therapy by Tonne, Jason M, Sakuma, Toshie, Deeds, Michael C, Munoz-Gomez, Miguel, Barry, Michael A, Kudva, Yogish C, Ikeda, Yasuhiro

    Published in Disease models & mechanisms (01-09-2013)
    “…Streptozotocin (STZ), a glucosamine-nitrosourea compound, has potent genotoxic effects on pancreatic β-cells and is frequently used to induce diabetes in…”
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    Murine leukemia virus uses TREX components for efficient nuclear export of unspliced viral transcripts by Sakuma, Toshie, Tonne, Jason M, Ikeda, Yasuhiro

    Published in Viruses (10-03-2014)
    “…Previously we reported that nuclear export of both unspliced and spliced murine leukemia virus (MLV) transcripts depends on the nuclear export factor (NXF1)…”
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    Beta cell regeneration after single-round immunological destruction in a mouse model by Tonne, Jason M., Sakuma, Toshie, Munoz-Gomez, Miguel, El Khatib, Moustafa, Barry, Michael A., Kudva, Yogish C., Ikeda, Yasuhiro

    Published in Diabetologia (01-02-2015)
    “…Aims/hypothesis Achieving a better understanding of beta cell regeneration after immunological destruction is crucial for the development of immunotherapy…”
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    Intranasal Prime-Boost with Spike Vectors Generates Antibody and T-Cell Responses at the Site of SARS-CoV-2 Infection by Metko, Muriel, Tonne, Jason, Veliz Rios, Alexa, Thompson, Jill, Mudrick, Haley, Masopust, David, Diaz, Rosa Maria, Barry, Michael A, Vile, Richard G

    Published in Vaccines (Basel) (01-10-2024)
    “…Long-lived, re-activatable immunity to SARS-CoV-2 and its emerging variants will rely on T cells recognizing conserved regions of viral proteins across…”
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    Divergent susceptibilities to AAV-SaCas9-gRNA vector-mediated genome-editing in a single-cell-derived cell population by Morsy, Salma G, Tonne, Jason M, Zhu, Yaxi, Lu, Brian, Budzik, Karol, Krempski, James W, Ali, Sherine A, El-Feky, Mohamed A, Ikeda, Yasuhiro

    Published in BMC research notes (08-12-2017)
    “…Recombinant adeno-associated virus (AAV)-based vectors are characterized by their robust and safe transgene delivery. The CRISPR/Cas9 and guide RNA (gRNA)…”
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