Search Results - "Tonne, Jason"
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Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue
Published in Diabetes (New York, N.Y.) (01-06-2016)“…Considerable evidence implicates cellular senescence in the biology of aging and chronic disease. Diet and exercise are determinants of healthy aging; however,…”
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2
Oncolytic virus-derived type I interferon restricts CAR T cell therapy
Published in Nature communications (24-06-2020)“…The application of adoptive T cell therapies, including those using chimeric antigen receptor (CAR)-modified T cells, to solid tumors requires combinatorial…”
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3
APOBEC3B-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapy
Published in Nature communications (07-02-2020)“…APOBEC3B, an anti-viral cytidine deaminase which induces DNA mutations, has been implicated as a mediator of cancer evolution and therapeutic resistance…”
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4
Expression of tumor antigens within an oncolytic virus enhances the anti-tumor T cell response
Published in Nature communications (27-06-2024)“…Although patients benefit from immune checkpoint inhibition (ICI) therapy in a broad variety of tumors, resistance may arise from immune suppressive tumor…”
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B-Type Natriuretic Peptide Deletion Leads to Progressive Hypertension, Associated Organ Damage, and Reduced Survival: Novel Model for Human Hypertension
Published in Hypertension (Dallas, Tex. 1979) (01-07-2015)“…Altered myocardial structure and function, secondary to chronically elevated blood pressure, are leading causes of heart failure and death. B-type natriuretic…”
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6
Murine leukemia virus uses NXF1 for nuclear export of spliced and unspliced viral transcripts
Published in Journal of virology (01-04-2014)“…Intron-containing mRNAs are subject to restricted nuclear export in higher eukaryotes. Retroviral replication requires the nucleocytoplasmic transport of both…”
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7
Generation of a Tumor-Specific Chemokine Gradient Using Oncolytic Vesicular Stomatitis Virus Encoding CXCL9
Published in Molecular therapy. Oncolytics (27-03-2020)“…Genetically modified vesicular stomatitis virus (VSV) is an attractive agent for cancer treatment due to rapid intratumoral replication and observed clinical…”
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Long-Term Cardiac pro-B-Type Natriuretic Peptide Gene Delivery Prevents the Development of Hypertensive Heart Disease in Spontaneously Hypertensive Rats
Published in Circulation (New York, N.Y.) (29-03-2011)“…Diastolic dysfunction associated with high blood pressure (BP) leads to cardiac remodeling and fibrosis and progression to congestive heart failure. B-type…”
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Oncolytic virotherapy induced CSDE1 neo-antigenesis restricts VSV replication but can be targeted by immunotherapy
Published in Nature communications (26-03-2021)“…In our clinical trials of oncolytic vesicular stomatitis virus expressing interferon beta (VSV-IFNβ), several patients achieved initial responses followed by…”
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Impaired β-cell glucokinase as an underlying mechanism in diet-induced diabetes
Published in Disease models & mechanisms (01-06-2018)“…High-fat diet (HFD)-fed mouse models have been widely used to study early type 2 diabetes. Decreased β-cell glucokinase (GCK) expression has been observed in…”
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APOBEC3B expression in 293T viral producer cells drives mutations in chimeric antigen receptors and reduces CAR T cell efficacy
Published in Molecular Therapy: Oncology (19-12-2024)“…Chimeric antigen receptor (CAR) T cells are a clinically approved therapy for blood cancers. To produce clinical-grade CAR T cells, a retroviral or lentiviral…”
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Smoldering oncolysis by foamy virus carrying CD19 as a CAR target escapes CAR T detection by genomic modification
Published in Molecular Therapy: Oncology (19-09-2024)“…Chimeric antigen receptor (CAR) T cells have had limited success against solid tumors. Here, we used an oncolytic foamy virus (oFV) to display a model CAR…”
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13
Secretion of Glycosylated Pro―B-Type Natriuretic Peptide from Normal Cardiomyocytes
Published in Clinical chemistry (Baltimore, Md.) (01-06-2011)“…B-type natriuretic peptide (BNP), a key cardiac hormone in cardiorenal homeostasis, is produced as a 108 amino acid prohormone, proBNP1-108, which is converted…”
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A phase I oncolytic virus trial with vesicular stomatitis virus expressing human interferon beta and tyrosinase related protein 1 administered intratumorally and intravenously in uveal melanoma: safety, efficacy, and T cell responses
Published in Frontiers in immunology (2023)“…Metastatic uveal melanoma (MUM) has a poor prognosis and treatment options are limited. These patients do not typically experience durable responses to immune…”
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No evidence of XMRV in prostate cancer cohorts in the Midwestern United States
Published in Retrovirology (29-03-2011)“…Xenotropic murine leukemia virus (MLV)-related virus (XMRV) was initially identified in prostate cancer (PCa) tissue, particularly in the prostatic stromal…”
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Global gene expression profiling of pancreatic islets in mice during streptozotocin-induced β-cell damage and pancreatic Glp-1 gene therapy
Published in Disease models & mechanisms (01-09-2013)“…Streptozotocin (STZ), a glucosamine-nitrosourea compound, has potent genotoxic effects on pancreatic β-cells and is frequently used to induce diabetes in…”
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Murine leukemia virus uses TREX components for efficient nuclear export of unspliced viral transcripts
Published in Viruses (10-03-2014)“…Previously we reported that nuclear export of both unspliced and spliced murine leukemia virus (MLV) transcripts depends on the nuclear export factor (NXF1)…”
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Beta cell regeneration after single-round immunological destruction in a mouse model
Published in Diabetologia (01-02-2015)“…Aims/hypothesis Achieving a better understanding of beta cell regeneration after immunological destruction is crucial for the development of immunotherapy…”
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Intranasal Prime-Boost with Spike Vectors Generates Antibody and T-Cell Responses at the Site of SARS-CoV-2 Infection
Published in Vaccines (Basel) (01-10-2024)“…Long-lived, re-activatable immunity to SARS-CoV-2 and its emerging variants will rely on T cells recognizing conserved regions of viral proteins across…”
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Divergent susceptibilities to AAV-SaCas9-gRNA vector-mediated genome-editing in a single-cell-derived cell population
Published in BMC research notes (08-12-2017)“…Recombinant adeno-associated virus (AAV)-based vectors are characterized by their robust and safe transgene delivery. The CRISPR/Cas9 and guide RNA (gRNA)…”
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