Biomass smoke COPD has less tomographic abnormalities but worse hypoxemia compared with tobacco COPD

Special attention has emerged towards biomass smoke-induced chronic obstructive pulmonary disease (COPD), providing new knowledge for prevention and therapeutic approach of non-smoker COPD patients. However, the understanding of biomass smoke COPD is still limited and somewhat controversial. The aim...

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Bibliographic Details
Published in:	Brazilian journal of medical and biological research Vol. 52; no. 5; p. e8233
Main Authors:	Meneghini, A C, Koenigkam-Santos, M, Pereira, M C, Tonidandel, P R, Terra-Filho, J, Cunha, F Q, Menezes, M B de, Vianna, E O
Format:	Journal Article
Language:	English
Published:	Brazil Associacao Brasileira de Divulgacao Cientifica (ABDC) 01-01-2019 Revista Brasileira de Pesquisas Medicas Associação Brasileira de Divulgação Científica
Subjects:	Aged Ambulatory care facilities Analysis Anoxemia Biological markers BIOLOGY Biomass CAT scans Chronic obstructive lung disease Chronic obstructive pulmonary disease Cigarettes Computed tomography Cross-Sectional Studies Dyspnea Emphysema Environmental Exposure Female Health aspects Humans Hypoxemia Hypoxia - diagnostic imaging Hypoxia - etiology Inflammation Interleukin 8 Interleukins Lung diseases Male Medical research Medical tests MEDICINE, RESEARCH & EXPERIMENTAL Middle Aged Nicotiana - adverse effects Obstructive lung disease Oxygen tension Public health Pulmonary Disease, Chronic Obstructive - diagnostic imaging Pulmonary Disease, Chronic Obstructive - etiology Pulmonary function tests Respiration Respiratory function Respiratory Function Tests Respiratory therapy Smoke Smoke - adverse effects Smokers Smoking Spirometry Sputum Sputum - chemistry Thorax Tobacco Tobacco smoking Tomography Tomography, X-Ray Computed Tobacco Chronic obstructive pulmonary disease Biomass
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Summary:	Special attention has emerged towards biomass smoke-induced chronic obstructive pulmonary disease (COPD), providing new knowledge for prevention and therapeutic approach of non-smoker COPD patients. However, the understanding of biomass smoke COPD is still limited and somewhat controversial. The aim of the present study was to compare COPD exclusively caused by tobacco smoking with COPD exclusively caused by environmental or occupational exposures. For this cross-sectional study, COPD patients were recruited from outpatient clinics and formed two groups: non-smoker COPD group (n=16) with exposure to biomass smoke who did not smoke cigarette and tobacco smoker COPD group (n=15) with people who did not report biomass smoke exposure. Subjects underwent pulmonary function tests, thoracic high-resolution computed tomography, 6-min walk test, and sputum induction. The non-smoker COPD group had biomass smoke exposure of 133.3±86 hour-years. The tobacco COPD group smoked 48.5±27.4 pack-years. Women were 62.5 and 66.7%, respectively, of non-smokers and smokers. The non-smoker COPD group showed higher prevalence of dyspnea, lower arterial oxygen tension (PaO2), and lower arterial oxygen saturation (SaO2%) with similar spirometry results, lung volumes, and diffusion capacity. Regarding inflammatory biomarkers, differences were detected in sputum number of lymphomononuclear cells and in sputum concentrations of interleukin (IL)-6 and IL-8 with higher values in the smoker group. Emphysema was more prevalent in the tobacco smoker group, which also showed higher relative bronchial wall thickness and lower lung density by quantitative analysis. Biomass smoke induced more hypoxemia compared to tobacco in COPD patients with similar severity.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 In memoriam
ISSN:	0100-879X 1414-431X 1414-431X 1678-4510
DOI:	10.1590/1414-431x20198233