Autophagy in the brain of neonates following hypoxia–ischemia shows sex- and region-specific effects

Highlights • Autophagy and apoptosis were studied in the brain following hypoxia–ischemia (HI). • The function of lysosomes decreased in female but not in the male cortex following HI. • Activation of autophagy occurred in the cortex and the hippocampus after HI. • Females had greater caspase-3 acti...

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Published in:	Neuroscience Vol. 256; pp. 201 - 209
Main Authors:	Weis, S.N, Toniazzo, A.P, Ander, B.P, Zhan, X, Careaga, M, Ashwood, P, Wyse, A.T.S, Netto, C.A, Sharp, F.R
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier 03-01-2014
Subjects:	Analysis of Variance Animals Animals, Newborn Autophagy - physiology Biological and medical sciences Brain - metabolism Brain - pathology Caspase 3 - metabolism Caspase 7 - metabolism Disease Models, Animal Female Flow Cytometry Fundamental and applied biological sciences. Psychology Hypoxia-Ischemia, Brain - pathology Hypoxia-Ischemia, Brain - physiopathology Male Medical sciences Microtubule-Associated Proteins - metabolism Neurology Rats Rats, Sprague-Dawley Sex Characteristics Vascular diseases and vascular malformations of the nervous system Vertebrates: nervous system and sense organs HI Terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling LysoTracker Red PND neonatal LTR microtubule-associated protein light chain 3 TUNEL analysis of variance ANOVA postnatal day lysosomes LC3 AIF PBS Phosphate-buffered saline hypoxia phosphatidyl ethanolamine autophagy autophagy-related genes sex hypoxia–ischemia ischemia Atg PE apoptosis-inducing factor Oxygen Nervous system diseases Central nervous system Lysosome Sex Environmental factor Cardiovascular disease Autophagy Cerebral disorder Encephalon Vascular disease Central nervous system disease Brain ischemia Hypoxia Cerebrovascular disease
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Summary:	Highlights • Autophagy and apoptosis were studied in the brain following hypoxia–ischemia (HI). • The function of lysosomes decreased in female but not in the male cortex following HI. • Activation of autophagy occurred in the cortex and the hippocampus after HI. • Females had greater caspase-3 activation than males in the cortex/hippocampus following HI. • Autophagy and apoptosis activation by HI differed by sex and brain region.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.10.046