Growth, clinical and neurodevelopmental outcomes at school age are similar for children who received 1-year lamivudine or lopinavir/ritonavir HIV prophylaxis in early life

In the ANRS 12174 trial, HIV-exposed uninfected African neonates who received lopinavir-ritonavir (LPV/r) prophylaxis for 1 year exhibited slower growth from birth to week 50 compared with those receiving lamivudine (3TC). We assessed whether this difference in growth persisted over time, and was ac...

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Bibliographic Details
Published in:	Scientific reports Vol. 11; no. 1; p. 3173
Main Authors:	Nagot, Nicolas, Singata-Madliki, Mandisa, Cournil, Amandine, Nalugya, Joyce, Tassembedo, Souleymane, Quillet, Catherine, Tonga, Melany W., Tumwine, James, Meda, Nicolas, Kankasa, Chipepo, Mwiya, Mwiya, Bangirana, Paul, Peries, Marianne, Batting, Joanne, Engebretsen, Ingunn M. S., Tylleskär, Thorkild, Perre, Philippe Vande, Ndeezi, Grace, Molès, Jean-Pierre
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 04-02-2021 Nature Publishing Group Nature Portfolio
Subjects:	692/308/3187 692/699/255/1901 Antiretroviral agents Antiretroviral drugs Antiviral drugs Children Clinical outcomes HIV Human health and pathology Human immunodeficiency virus Humanities and Social Sciences Infectious diseases Lamivudine Life Sciences Lopinavir multidisciplinary Neonates Pediatrics Pharmaceutical sciences Pharmacology Prophylaxis Ritonavir Santé publique et épidémiologie Science Science (multidisciplinary) Side effects
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Summary:	In the ANRS 12174 trial, HIV-exposed uninfected African neonates who received lopinavir-ritonavir (LPV/r) prophylaxis for 1 year exhibited slower growth from birth to week 50 compared with those receiving lamivudine (3TC). We assessed whether this difference in growth persisted over time, and was accompanied by differences in neuropsychological and clinical outcomes. Between February 2017 and February 2018, we conducted a cross-sectional clinical evaluation among former trial participants who completed the 50-week follow-up and who were not HIV-infected. In addition to clinical examination, neuropsychological outcomes were assessed using the tests Kaufman-ABCII, Test of Variables of Attention, Movement Assessment Battery for Children and the Strengths and Difficulties questionnaire, parent version. Of 1101 eligible children, aged 5–7 years, 553 could be traced and analysed (274 in the LPV/r and 279 in the 3TC groups). Growth, clinical and neuropsychological outcomes did not differ between treatment groups. At school age, children exposed to LPV/r and 3TC at birth for 1 year had comparable growth and neuropsychological outcomes without evidence of long-term side-effects of LPV/r. It provides reassuring data on clinical outcomes for all HIV-infected children treated with this antiretroviral drug in early life.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-News-2 ObjectType-Feature-3 content type line 23 PMCID: PMC7862474
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-021-82762-8