Search Results - "Tong, Zhenbo"

Comparative Analysis of Micrometer-Sized Particle Deposition in the Olfactory Regions of Adult and Pediatric Nasal Cavities: A Computational Study by Jin, Ziyu, Guo, Gang, Yu, Aibing, Qian, Hua, Tong, Zhenbo

“…Direct nose-to-brain drug delivery, a promising approach for treating neurological disorders, faces challenges due to anatomical variations between adults and…”
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Preparation of lipid nanoparticles by micro-mixer Process simulation and experimental study by Li, Bing, Miao, Hao, Tong, Zhenbo

“…Controlling the sizes of liposomes is critical in drug delivery systems because it directly influences their cellular uptake, transportation, and accumulation…”
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Intratumoral delivered novel circular mRNA encoding cytokines for immune modulation and cancer therapy by Yang, Jiali, Zhu, Jiafeng, Sun, Jiaojiao, Chen, Yiyun, Du, Yaran, Tan, Yiling, Wu, Linpeng, Zhai, Mengting, Wei, Lixiang, Li, Na, Huang, Ke, Hou, Qiangbo, Tong, Zhenbo, Bechthold, Andreas, Tian, Hao, Sun, Zhenhua, Zuo, Chijian

“…The success of the two mRNA vaccines developed by Moderna and BioNTech during the COVID-19 pandemic increased research interest into the application of mRNA…”
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In silico Study on the deposition and distribution of particles in a realistic airway model with Handilaher by Li, Yaning, Huang, Fen, Zhou, Xudong, Tong, Zhenbo

“…Effective pulmonary drug delivery plays an essential role in the treatment of diseases. Drug aerosolization and inhalers play an essential role in the…”
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Discrete Modelling of Powder Dispersion in Dry Powder Inhalers - A Brief Review by Tong, Zhenbo, Yu, Aibing, Chan, Hak-Kim, Yang, Runyu

“…The performance of a dry powder inhaler (DPI) depends on powder properties as well as the air and particle flows in the device. The main principle of powder…”
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Pharmacokinetic prediction of nebulised polymyxin for pulmonary delivery by Hu, Tian, Miao, Hao, Zhou, Xudong, Qiu, Shi, Tong, Zhenbo

“…Inhaled administration of polymyxin B is increasingly used to treat multi-drug resistant bacterial lung infections. However, the lack of clinical data on the…”
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Effect of Device Design on the Aerosolization of a Carrier-Based Dry Powder Inhaler—a Case Study on Aerolizer® Foradile by Zhou, Qi Tony, Tong, Zhenbo, Tang, Patricia, Citterio, Mauro, Yang, Runyu, Chan, Hak-Kim

“…The objective of this study is to investigate the effect of device design of the Aerolizer ® on the aerosolization of a carrier-based dry powder inhaler…”
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De-agglomeration Effect of the US Pharmacopeia and Alberta Throats on Carrier-Based Powders in Commercial Inhalation Products by Leung, Sharon Shui Yee, Tang, Patricia, Zhou, Qi (Tony), Tong, Zhenbo, Leung, Cassandra, Decharaksa, Janwit, Yang, Runyu, Chan, Hak-Kim

“…The US pharmacopeia (USP) and Alberta throats were recently reported to cause further de-agglomeration of carrier-free powders emitted from some dry powder…”
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Spray Dried Levodopa-Doped Powder Potentially for Intranasal Delivery by Liu, Xuan, Yan, Shen, Li, Mengyuan, Zhang, Shengyu, Guo, Gang, Yin, Quanyi, Tong, Zhenbo, Chen, Xiao Dong, Wu, Winston Duo

“…This work was aimed to develop levodopa (L-dopa) nasal powder to achieve controllable drug release and high nasal deposition efficiency. A series of uniform…”
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Numerical Simulation of Aspergillus Niger Spore Deposition in Nasal Cavities of a Population in Northwest China by Wang, Yusheng, Dong, Jingliang, Chen, Xiaole, Lou, Miao, Ma, Ruiping, Hu, Zhenzhen, Gong, Minjie, Wang, Botao, Tong, Zhenbo, Ren, Hongxian, Li, Chaofan, Zheng, Guoxi, Zhang, Ya

“…Background: As common pathogens in the human respiratory tract, fungal-spore-related health risks have been challenging to evaluate properly. This paper…”
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Does the United States Pharmacopeia Throat Introduce De-agglomeration of Carrier-Free Powder from Inhalers? by Tang, Patricia, Kwok, Philip Chi Lip, Tong, Zhenbo, Yang, Runyu, Raper, Judy Agnes, Chan, Hak-Kim

“…Purpose We hypothesize that the USP induction port may de-agglomerate carrier-free powder emitting from dry powder inhalers (DPIs). Methods Aerosols emitting…”
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Agglomerate strength and dispersion of pharmaceutical powders by Adi, Santoso, Adi, Handoko, Chan, Hak-Kim, Finlay, Warren H., Tong, Zhenbo, Yang, Runyu, Yu, Aibing

“…This study aims to investigate quantitatively the direct correlation between the mechanical strength of powder agglomerates and their dispersion into aerosols…”
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Impact angles as an alternative way to improve aerosolisation of powders for inhalation? by Adi, Santoso, Tong, Zhenbo, Chan, Hak-Kim, Yang, Runyu, Yu, Aibing

“…This study aims to investigate the role of impact angles on the de-agglomeration performance of powders for inhalation. Agglomerates of a model drug mannitol…”
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DEM/CFD-DEM Modelling of Non-spherical Particulate Systems: Theoretical Developments and Applications by Zhong, Wenqi, Yu, Aibing, Liu, Xuejiao, Tong, Zhenbo, Zhang, Hao

“…Particles encountered in nature and engineering practice are normally not spherical but of irregular shapes. Particle shape plays a key role in determining the…”
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Role of CFD based in silico modelling in establishing an in vitro-in vivo correlation of aerosol deposition in the respiratory tract by Huang, Fen, Zhu, Qixuan, Zhou, Xudong, Gou, Dazhao, Yu, Jiaqi, Li, Renjie, Tong, Zhenbo, Yang, Runyu

“…Effective evaluation and prediction of aerosol transport deposition in the human respiratory tracts are critical to aerosol drug delivery and evaluation of…”
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Numerical study on the deposition distribution and mechanism of inhaled drug particles in various regions of the realistic inhaler-airway model by Zhang, Lixing, Tong, Zhenbo, Zhang, Ya, Yu, Aibing

“…Inhaled drug delivery is widely used in the treatment of respiratory diseases. Understanding the deposition mechanisms of dry powder inhalers (DPIs) in…”
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Three-dimensional simulation of impinging jet atomization of soft mist inhalers using the hybrid VOF-DPM model by Jin, Wen, Xiao, Jie, Ren, Hongxian, Li, Changhui, Zheng, Qijun, Tong, Zhenbo

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The effect of the design of the mini cyclonic DPIs on the emitted dose by modelling approach by Li, Zeyu, Tong, Zhenbo, Zhang, Lixing, Huang, Fen, Yu, Aibing

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In Vitro and In Silico Investigations on Drug Delivery in the Mouth-Throat Models with Handihaler by Huang, Fen, Zhou, Xudong, Dai, Wen, Yu, Jiaqi, Zhou, Zongyan, Tong, Zhenbo, Yu, Aibing

“…This work aimed to evaluate the relative inhalation parameters that affect the deposition of inhaled aerosols, including mouth-throat morphology, airflow rate,…”
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CFD-DEM simulation of the supercritical water-solid flow in cyclone by Li, Zeyu, Tong, Zhenbo, Zhang, Hao, Chu, Kaiwei, Li, Renjie, Miao, Hao, Zhao, Jiansong, Yu, Aibing

“…With the increasingly growing energy demand and serious environmental pollution, the utilization of hydrogen energy is obtaining attention because it has high…”
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