Search Results - "Tong, Xinming"

Bioengineered 3D Brain Tumor Model To Elucidate the Effects of Matrix Stiffness on Glioblastoma Cell Behavior Using PEG-Based Hydrogels by Wang, Christine, Tong, Xinming, Yang, Fan

“…Glioblastoma (GBM) is the most common and aggressive form of primary brain tumor with a median survival of 12–15 months, and the mechanisms underlying GBM…”
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The effects of varying poly(ethylene glycol) hydrogel crosslinking density and the crosslinking mechanism on protein accumulation in three-dimensional hydrogels by Lee, Soah, Tong, Xinming, Yang, Fan

“…[Display omitted] Matrix stiffness has been shown to play an important role in modulating various cell fate processes such as differentiation and cell cycle…”
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Mimicking Cartilage Tissue Zonal Organization by Engineering Tissue-Scale Gradient Hydrogels as 3D Cell Niche by Zhu, Danqing, Tong, Xinming, Trinh, Pavin, Yang, Fan

“…Zonal organization plays an important role in cartilage structure and function, whereas most tissue-engineering strategies developed to date have only allowed…”
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Effect of matrix metalloproteinase‐mediated matrix degradation on glioblastoma cell behavior in 3D PEG‐based hydrogels by Wang, Christine, Tong, Xinming, Jiang, Xinyi, Yang, Fan

“…Glioblastoma (GBM) is the most common and aggressive form of primary brain tumor with median survival of 12 months. To improve clinical outcomes, it is…”
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Injectable and in situ crosslinkable gelatin microribbon hydrogels for stem cell delivery and bone regeneration in vivo by Tang, Yaohui, Tong, Xinming, Conrad, Bogdan, Yang, Fan

“…Rationale: Injectable matrices are highly desirable for stem cell delivery. Previous research has highlighted the benefit of scaffold macroporosity in…”
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Biochemical Ligand Density Regulates Yes-Associated Protein Translocation in Stem Cells through Cytoskeletal Tension and Integrins by Stanton, Alice E, Tong, Xinming, Lee, Soah, Yang, Fan

“…Different tissue types are characterized by varying stiffness and biochemical ligands. Increasing substrate stiffness has been shown to trigger Yes-associated…”
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Long-Term Controlled Protein Release from Poly(Ethylene Glycol) Hydrogels by Modulating Mesh Size and Degradation by Tong, Xinming, Lee, Soah, Bararpour, Layla, Yang, Fan

“…Poly(ethylene glycol) (PEG)‐based hydrogels are popular biomaterials for protein delivery to guide desirable cellular fates and tissue repair. However,…”
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Sexually dimorphic estrogen sensing in skeletal stem cells controls skeletal regeneration by Andrew, Tom W., Koepke, Lauren S., Wang, Yuting, Lopez, Michael, Steininger, Holly, Struck, Danielle, Boyko, Tatiana, Ambrosi, Thomas H., Tong, Xinming, Sun, Yuxi, Gulati, Gunsagar S., Murphy, Matthew P., Marecic, Owen, Tevlin, Ruth, Schallmoser, Katharina, Strunk, Dirk, Seita, Jun, Goodman, Stuart B., Yang, Fan, Longaker, Michael T., Yang, George P., Chan, Charles K. F.

“…Sexually dimorphic tissues are formed by cells that are regulated by sex hormones. While a number of systemic hormones and transcription factors are known to…”
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Pharmacological rescue of diabetic skeletal stem cell niches by Tevlin, Ruth, Seo, Eun Young, Marecic, Owen, McArdle, Adrian, Tong, Xinming, Zimdahl, Bryan, Malkovskiy, Andrey, Sinha, Rahul, Gulati, Gunsagar, Li, Xiyan, Wearda, Taylor, Morganti, Rachel, Lopez, Michael, Ransom, Ryan C, Duldulao, Christopher R, Rodrigues, Melanie, Nguyen, Allison, Januszyk, Michael, Maan, Zeshaan, Paik, Kevin, Yapa, Kshemendra-Senarath, Rajadas, Jayakumar, Wan, Derrick C, Gurtner, Geoffrey C, Snyder, Michael, Beachy, Philip A, Yang, Fan, Goodman, Stuart B, Weissman, Irving L, Chan, Charles K F, Longaker, Michael T

“…Diabetes mellitus (DM) is a metabolic disease frequently associated with impaired bone healing. Despite its increasing prevalence worldwide, the molecular…”
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Author Correction: Sexually dimorphic estrogen sensing in skeletal stem cells controls skeletal regeneration by Andrew, Tom W., Koepke, Lauren S., Wang, Yuting, Lopez, Michael, Steininger, Holly, Struck, Danielle, Boyko, Tatiana, Ambrosi, Thomas H., Tong, Xinming, Sun, Yuxi, Gulati, Gunsagar S., Murphy, Matthew P., Marecic, Owen, Tevlin, Ruth, Schallmoser, Katharina, Strunk, Dirk, Seita, Jun, Goodman, Stuart B., Yang, Fan, Longaker, Michael T., Yang, George P., Chan, Charles K. F.

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Evaluation of an in situ chemically crosslinked hydrogel as a long-term vitreous substitute material by Tao, Yong, Tong, Xinming, Zhang, Yan, Lai, Jingjing, Huang, Yanbin, Jiang, Yan-Rong, Guo, Bao-Hua

“…Currently there is no material that can be used as a long-term vitreous substitute, and this remains an unmet clinical need in ophthalmology. In this study, we…”
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Aged skeletal stem cells generate an inflammatory degenerative niche by Ambrosi, Thomas H., Marecic, Owen, McArdle, Adrian, Sinha, Rahul, Gulati, Gunsagar S., Tong, Xinming, Wang, Yuting, Steininger, Holly M., Hoover, Malachia Y., Koepke, Lauren S., Murphy, Matthew P., Sokol, Jan, Seo, Eun Young, Tevlin, Ruth, Lopez, Michael, Brewer, Rachel E., Mascharak, Shamik, Lu, Laura, Ajanaku, Oyinkansola, Conley, Stephanie D., Seita, Jun, Morri, Maurizio, Neff, Norma F., Sahoo, Debashis, Yang, Fan, Weissman, Irving L., Longaker, Michael T., Chan, Charles K. F.

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Improved Approach for Chondrogenic Differentiation of Human Induced Pluripotent Stem Cells by Nejadnik, Hossein, Diecke, Sebastian, Lenkov, Olga D., Chapelin, Fanny, Donig, Jessica, Tong, Xinming, Derugin, Nikita, Chan, Ray C. F., Gaur, Amitabh, Yang, Fan, Wu, Joseph C., Daldrup-Link, Heike E.

“…Human induced pluripotent stem cells (hiPSCs) have demonstrated great potential for hyaline cartilage regeneration. However, current approaches for…”
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Varying solvent type modulates collagen coating and stem cell mechanotransduction on hydrogel substrates by Stanton, Alice E., Tong, Xinming, Yang, Fan

“…Type I collagen is the most abundant extracellular matrix protein in the human body and is commonly used as a biochemical ligand for hydrogel substrates to…”
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Effects of Polymer End-Group Chemistry and Order of Deposition on Controlled Protein Delivery from Layer-by-Layer Assembly by Keeney, Michael, Mathur, Melina, Cheng, Emily, Tong, Xinming, Yang, Fan

“…Layer-by-layer (LBL) assembly is an attractive platform for controlled release of biologics given its mild fabrication process and versatility in coating…”
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Del1 Is a Growth Factor for Skeletal Progenitor Cells in the Fracture Callus by Sun, Yuxi, Boyko, Tatiana, Marecic, Owen, Struck, Danielle, Mann, Randall K, Andrew, Tom W, Lopez, Michael, Tong, Xinming, Goodman, Stuart B, Yang, Fan, Longaker, Michael T, Chan, Charles K. F, Yang, George P

“…Failure to properly form bone or integrate surgical implants can lead to morbidity and additional surgical interventions in a significant proportion of…”
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Glutathione as the End Capper for Cyclodextrin/PEG Polyrotaxanes by Song, Qiao, Luo, Zhi, Tong, Xinming, Du, Yi, Huang, Yanbin

“…A facile one-pot synthesis of α-cyclodextrin-based polyrotaxane （PR） in aqueous solution is reported, where the peptide glutathione was used as the end-capping…”
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Novel main-chain polyrotaxanes synthesized via ATRP of HEMA initiated with polypseudorotaxanes comprising BriB–PEG–iBBr and α-CDs by Tong, Xinming, Zhang, Xiaowen, Ye, Lin, Zhang, Ai-ying, Feng, Zeng-guo

“…A novel strategy for the preparation of main-chain polyrotaxanes with lengthily tunable PHEMA as outer bulky stoppers was described in the present study…”
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Impairment in Fracture Healing in a Mouse Model of Type 2 Diabetes Is Driven by Skeletal Stem Cell Niche Dysregulation by Tevlin, Ruth, MB, BCh, MRCSI, Seo, Eun Young, Ardle, Adrian Mc, MB, BCh, MRCSI, Tong, Xinming, PhD, Januszyk, Michael, MD, PhD, Yang, Fan, PhD, Gurtner, Geoffrey C., MD, FACS, Chan, Charles K.F., PhD, Weissman, Irving L., MD, Longaker, Michael T., MD, MBA, FACS

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Sliding Hydrogels with Mobile Molecular Ligands and Crosslinks as 3D Stem Cell Niche by Tong, Xinming, Yang, Fan

“…The development of a sliding hydrogel with mobile crosslinks and biochemical ligands as a 3D stem cell niche is reported. The molecular mobility of this…”
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