Search Results - "Tong, Xiaoyong"

Cross-Talk between Mechanosensitive Ion Channels and Calcium Regulatory Proteins in Cardiovascular Health and Disease by Wang, Yaping, Shi, Jian, Tong, Xiaoyong

“…Mechanosensitive ion channels are widely expressed in the cardiovascular system. They translate mechanical forces including shear stress and stretch into…”
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Autophagy and oxidative stress in cardiovascular diseases by Mei, Yu, Thompson, Melissa D., Cohen, Richard A., Tong, XiaoYong

“…Autophagy is a highly conserved degradation process by which intracellular components, including soluble macromolecules (e.g. nucleic acids, proteins,…”
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Editorial: Mechanism and therapeutic potential of macrophages in metabolic and cardiovascular diseases by Nie, Xuqiang, Deng, Youcai, Tong, Xiaoyong, Han, Felicity

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Editorial: Bioactive substances-mediated targeted therapy of cardio-cerebrovascular diseases by Tong, Xiaoyong, Tan, Yi, Chen, Linxi, Wang, Guixue

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Vascular Oxidative Stress: The Common Link in Hypertensive and Diabetic Vascular Disease by Cohen, Richard A, Tong, XiaoYong

“…Vascular disease in hypertension and diabetes is associated with increased oxidants. The oxidants arise from NADPH oxidase, xanthine oxidase, and mitochondria…”
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The Therapeutic Strategies Targeting Mitochondrial Metabolism in Cardiovascular Disease by Huang, Xiaoyang, Zeng, Zhenhua, Li, Siqi, Xie, Yufei, Tong, Xiaoyong

“…Cardiovascular disease (CVD) is a group of systemic disorders threatening human health with complex pathogenesis, among which mitochondrial energy metabolism…”
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Inactivation of cysteine 674 in the SERCA2 accelerates experimental aortic aneurysm by Que, Yumei, Shu, Xi, Wang, Langtao, Hu, Pingping, Wang, Sai, Xiong, Rui, Liu, Jin, Chen, Hao, Tong, Xiaoyong

“…Sarcoplasmic/endoplasmic reticulum Ca2+ ATPase 2 (SERCA2) is vital to maintain intracellular calcium homeostasis. SERCA2 cysteine 674 (C674) is highly…”
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Upregulation of Nox4 by TGFβ1 Oxidizes SERCA and Inhibits NO in Arterial Smooth Muscle of the Prediabetic Zucker Rat by Tong, XiaoYong, Hou, Xiuyun, Jourdʼheuil, David, Weisbrod, Robert M, Cohen, Richard A

“…RATIONALE:Vascular smooth muscle cell (SMC) migration is an important pathological process in several vascular occlusive diseases, including atherosclerosis…”
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Substitution of the SERCA2 Cys674 reactive thiol accelerates atherosclerosis by inducing endoplasmic reticulum stress and inflammation by Su, Hang, Mei, Yu, Luo, Shuangxue, Wu, Haixia, He, Yan, Shiraishi, Yasunaga, Hu, Pingping, Cohen, Richard A., Tong, Xiaoyong

“…Background and Purpose The cysteine674 (C674) thiol of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase 2 is easily and irreversibly oxidized under…”
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CDN1163 alleviates SERCA2 dysfunction-induced pulmonary vascular remodeling by inhibiting the phenotypic transition of pulmonary artery smooth muscle cells by Yu, Weimin, Zhang, Qian, Qiu, Yixiang, Chen, Hui, Huang, Xiaoyang, Xiao, Li, Xu, Gang, Li, Siqi, Hu, Pingping, Tong, Xiaoyong

“…BACKGROUND AND PURPOSESubstitution of Cys674 (C674) in the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase 2 (SERCA2) causes SERCA2 dysfunction which leads to…”
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Sodium-glucose cotransporter 2 inhibitors attenuate vascular calcification by suppressing endoplasmic reticulum protein thioredoxin domain containing 5 dependent osteogenic reprogramming by Wu, Shaofa, Luo, Xiaolin, Chen, Yang, Wang, Zelan, Liu, Xi, Sun, Ning, Zhao, Junyong, Luo, Wenjian, Zhang, Jiawen, Tong, Xiaoyong, Huang, Lan, Liu, Chuan, Qin, Zhexue

“…Vascular calcification is strongly linked to the development of major adverse cardiovascular events, but effective treatments are lacking. Sodium-glucose…”
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Glutathione Adducts on Sarcoplasmic/Endoplasmic Reticulum Ca2+ ATPase Cys-674 Regulate Endothelial Cell Calcium Stores and Angiogenic Function as Well as Promote Ischemic Blood Flow Recovery by Thompson, Melissa D., Mei, Yu, Weisbrod, Robert M., Silver, Marcy, Shukla, Praphulla C., Bolotina, Victoria M., Cohen, Richard A., Tong, Xiaoyong

“…The sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) is key to Ca2+ homeostasis and is redox-regulated by reversible glutathione (GSH) adducts on the cysteine…”
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Both hydrogen peroxide and transforming growth factor beta 1 contribute to endothelial Nox4 mediated angiogenesis in endothelial Nox4 transgenic mouse lines by Chen, Lili, Hou, Xiuyun, Xiao, Jennifer, Kuroda, Junya, Ago, Tetsuro, Sadoshima, Junichi, Cohen, Richard A., Tong, XiaoYong

“…Vascular endothelial cells (ECs) are responsible for post-ischemic angiogenesis, a process that is regulated by reactive oxygen species. Recent studies…”
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Endothelial Nox4-based NADPH oxidase regulates atherosclerosis via soluble epoxide hydrolase by Hu, Pingping, Wu, Xiaojuan, Khandelwal, Alok R., Yu, Weimin, Xu, Zaicheng, Chen, Lili, Yang, Jian, Weisbrod, Robert M., Lee, Kin Sing Stephen, Seta, Francesca, Hammock, Bruce D., Cohen, Richard A., Zeng, Chunyu, Tong, Xiaoyong

“…Nox4-based NADPH oxidase is a major reactive oxygen species-generating enzyme in the vasculature, but its role in atherosclerosis remains controversial. Our…”
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Nitroxyl Activates SERCA in Cardiac Myocytes via Glutathiolation of Cysteine 674 by Lancel, Steve, Zhang, Jingmei, Evangelista, Alicia, Trucillo, Mario P, Tong, XiaoYong, Siwik, Deborah A, Cohen, Richard A, Colucci, Wilson S

“…Nitroxyl (HNO) exerts inotropic and lusitropic effects in myocardium, in part via activation of SERCA (sarcoplasmic reticulum calcium ATPase). To elucidate the…”
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Role of smooth muscle Nox4-based NADPH oxidase in neointimal hyperplasia by Tong, Xiaoyong, Khandelwal, Alok R, Qin, Zhexue, Wu, Xiaojuan, Chen, Lili, Ago, Tetsuro, Sadoshima, Junichi, Cohen, Richard A

“…Abstract Elevated levels of reactive oxygen species (ROS) in the vascular wall play a key role in the development of neointimal hyperplasia. Nox4-based NADPH…”
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Inactivation of Cys674 in SERCA2 increases BP by inducing endoplasmic reticulum stress and soluble epoxide hydrolase by Liu, Gang, Wu, Fuhua, Jiang, Xiaoli, Que, Yumei, Qin, Zhexue, Hu, Pingping, Lee, Kin Sing Stephen, Yang, Jian, Zeng, Chunyu, Hammock, Bruce D., Tong, Xiaoyong

“…Background and Purpose The kidney is essential in regulating sodium homeostasis and BP. The irreversible oxidation of Cys674 (C674) in the…”
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Targeting the redox regulation of SERCA in vascular physiology and disease by Tong, XiaoYong, Evangelista, Alicia, Cohen, Richard A

“…The sarco/endoplasmic reticulum calcium ATPase (SERCA) is essential for the control of intracellular free Ca2+ levels. Although the importance for this enzyme…”
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Pro-atherogenic role of smooth muscle Nox4-based NADPH oxidase by Tong, Xiaoyong, Khandelwal, Alok R, Wu, Xiaojuan, Xu, Zaicheng, Yu, Weimin, Chen, Caiyu, Zhao, Wanzhou, Yang, Jian, Qin, Zhexue, Weisbrod, Robert M, Seta, Francesca, Ago, Tetsuro, Lee, Kin Sing Stephen, Hammock, Bruce D, Sadoshima, Junichi, Cohen, Richard A, Zeng, Chunyu

“…Abstract Nox4-based NADPH oxidase is a major reactive oxygen species-generating enzyme in the vasculature, but its role in atherosclerosis remains…”
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The substitution of SERCA2 redox cysteine 674 promotes pulmonary vascular remodeling by activating IRE1α/XBP1s pathway by Yu, Weimin, Xu, Gang, Chen, Hui, Xiao, Li, Liu, Gang, Hu, Pingping, Li, Siqi, Kasim, Vivi, Zeng, Chunyu, Tong, Xiaoyong

“…Pulmonary hypertension (PH) is a life-threatening disease characterized by pulmonary vascular remodeling, in which hyperproliferation of pulmonary artery…”
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