Search Results - "Tong, Qingyi"

Aspulvinone O, a natural inhibitor of GOT1 suppresses pancreatic ductal adenocarcinoma cells growth by interfering glutamine metabolism by Sun, Weiguang, Luan, Shanshan, Qi, Changxing, Tong, Qingyi, Yan, Shan, Li, Hua, Zhang, Yonghui

“…Distinctive from their normal counterparts, cancer cells exhibit unique metabolic dependencies on glutamine to fuel anabolic processes. Specifically,…”
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Hyalangiumruber sp. nov, characterization of a novel myxobacterium strain s54d21 and their secondary metabolites by Zang, Yi, Zhang, Xianjiao, Wang, Zhe, Tong, Qingyi, Zhou, Yang, Yao, Qing, Zhu, Honghui

“…Myxobacteria are special bacteria with wide adaptability, which are rich sources of structurally diverse natural products with intriguing biological…”
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Endoplasmic reticulum stress in melanoma pathogenesis and resistance by Kong, Yi, Jiang, Jian, Huang, Yuqiong, Li, Li, Liu, Xin, Jin, Zilin, Wei, Fen, Liu, Xinxin, Zhang, Song, Duan, Xiaoru, Zhang, Yonghui, Tong, Qingyi, Chen, Hongxiang

“…Melanoma is the most lethal skin cancer with rising incidence worldwide. Despite significant advances in target therapy and immunotherapy, low response rates…”
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Distachydrimanes A–F, phenylspirodrimane dimers and hybrids with cytotoxic activity from the coral-derived fungus Stachybotrys chartarum by Lin, Shuang, Huang, Jianzheng, Zeng, Hanxiao, Tong, Qingyi, Zhang, Xueke, Yang, Beiye, Ye, Ying, Wang, Jianping, Hu, Zhengxi, Zhang, Yonghui

“…By integrating one strain-many compounds (OSMAC) and LC–MS-based molecular networking strategies, distachydrimanes A–F (1–6), six novel phenylspirodrimane…”
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Dioscin inhibits colon tumor growth and tumor angiogenesis through regulating VEGFR2 and AKT/MAPK signaling pathways by Tong, Qingyi, Qing, Yong, Wu, Yang, Hu, Xiaojuan, Jiang, Lei, Wu, Xiaohua

“…Dioscin has shown cytotoxicity against cancer cells, but its in vivo effects and the mechanisms have not elucidated yet. The purpose of the current study was…”
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Kinsenoside Alleviates 17α-Ethinylestradiol-Induced Cholestatic Liver Injury in Rats by Inhibiting Inflammatory Responses and Regulating FXR-Mediated Bile Acid Homeostasis by Ming, Jiaxiong, Xu, Qianqian, Gao, Limin, Deng, Yanfang, Yin, Jie, Zhou, Qun, Tong, Qingyi, Zhang, Yonghui

“…Cholestasis is an important predisposing factor of liver diseases, such as hepatocyte necrosis, liver fibrosis and primary biliary cirrhosis. In this study, we…”
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Narciclasine inhibits phospholipase A2 and regulates phospholipid metabolism to ameliorate psoriasis-like dermatitis by Kong, Yi, Jiang, Jian, Huang, Yuqiong, Liu, Xin, Jin, Zilin, Li, Li, Wei, Fen, Liu, Xinxin, Yin, Jie, Zhang, Yonghui, Tong, Qingyi, Chen, Hongxiang

“…Psoriasis is a common inflammatory skin disease recognized by the World Health Organization as "an incurable chronic, noninfectious, painful, disfiguring and…”
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Small molecule activation of NOTCH signaling inhibits acute myeloid leukemia by Ye, Qi, Jiang, Jue, Zhan, Guanqun, Yan, Wanyao, Huang, Liang, Hu, Yufeng, Su, Hexiu, Tong, Qingyi, Yue, Ming, Li, Hua, Yao, Guangmin, Zhang, Yonghui, Liu, Hudan

“…Aberrant activation of the NOTCH signaling pathway is crucial for the onset and progression of T cell leukemia. Yet recent studies also suggest a tumor…”
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Single-cell transcriptomics reveals intestinal cell heterogeneity and identifies Ep300 as a potential therapeutic target in mice with acute liver failure by Yin, Jie, Zhao, Ziming, Huang, Jianzheng, Xiao, Yang, Rehmutulla, Mewlude, Zhang, Biqiong, Zhang, Zijun, Xiang, Ming, Tong, Qingyi, Zhang, Yonghui

“…Acute liver failure (ALF) is a severe life-threatening disease associated with the disorder of the gut-liver axis. However, the cellular characteristics of ALF…”
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Identification of anti‐Parkinson's Disease Lead Compounds from Aspergillus ochraceus Targeting Adenosin Receptors A2A by Hu, Linzhen, Tian, Shuying, Wu, Rongrong, Tong, Zhou, Jiang, Wen, Hu, Ping, Xiao, Xueyang, Zhang, Xueke, Zhou, Hui, Tong, Qingyi, Lu, Yuanyuan, Huang, Zhiyong, Chen, Yong, Zhang, Yonghui

“…Two novel alkaloids compounds together with fifteen know metabolites were identified from Aspergillus ochraceus. The stereochemistry features of the new…”
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Deltonin Isolated from Dioscorea zingiberensis Inhibits Cancer Cell Growth through Inducing Mitochondrial Apoptosis and Suppressing Akt and Mitogen Activated Protein Kinase Signals by Shu, Dan, Qing, Yong, Tong, Qingyi, He, Yang, Xing, Zhihua, Zhao, Yinglan, Li, Yi, Wei, Yuquan, Huang, Wen, Wu, Xiaohua

“…Deltonin is an active component purified from Dioscorea zingiberensis WRIGHT (DZW), and has shown anticancer effects. However, its mechanism of action remains…”
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(±)-Peniorthoesters A and B, Two Pairs of Novel Spiro-Orthoester en-antiomers With an Unusual 1,4,6-Trioxaspi-ro[4.5]decane-7-One Unit From Penicillium minioluteum by Liu, Xiaorui, Chen, Chunmei, Zheng, Yinyu, Zhang, Mi, Tong, Qingyi, Liu, Junjun, Zhou, Qun, Wang, Jianping, Luo, Zengwei, Zhu, Hucheng, Zhang, Yonghui

“…(±)-Peniorthoesters A and B (± and ± ), two pairs of unprecedented spiro-orthoester enantiomers with a 1,4,6-trioxaspiro[4. 5]decane-7-one unit, were obtained…”
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ZYH005, a novel DNA intercalator, overcomes all-trans retinoic acid resistance in acute promyelocytic leukemia by Tong, Qingyi, You, Huijuan, Chen, Xintao, Wang, Kongchao, Sun, Weiguang, Pei, Yufeng, Zhao, Xiaodan, Yuan, Ming, Zhu, Hucheng, Luo, Zengwei, Zhang, Yonghui

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Kinsenoside alleviates oxidative stress-induced blood-brain barrier dysfunction via promoting Nrf2/HO-1 pathway in ischemic stroke by Qiao, Nan, An, Zhaohong, Fu, Zeyu, Chen, Xingyu, Tong, Qingyi, Zhang, Yonghui, Ren, Hong

“…An ischemic stroke usually causes blood-brain barrier (BBB) damage and excessive oxidative stress (OS) levels. Kinsenoside (KD), a major effective compound…”
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Asperflavipine A: A Cytochalasan Heterotetramer Uniquely Defined by a Highly Complex Tetradecacyclic Ring System from Aspergillus flavipes QCS12 by Zhu, Hucheng, Chen, Chunmei, Tong, Qingyi, Yang, Jing, Wei, Guangzheng, Xue, Yongbo, Wang, Jianping, Luo, Zengwei, Zhang, Yonghui

“…Asperflavipines A (1) and B (2), two structurally complex merocytochalasans, were isolated from Aspergillus flavipes. Asperflavipine A (1), which contains two…”
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AsperflavipineA: A Cytochalasan Heterotetramer Uniquely Defined by a Highly Complex Tetradecacyclic Ring System from Aspergillus flavipes QCS12 by Zhu, Hucheng, Chen, Chunmei, Tong, Qingyi, Yang, Jing, Wei, Guangzheng, Xue, Yongbo, Wang, Jianping, Luo, Zengwei, Zhang, Yonghui

“…AsperflavipinesA (1) and B (2), two structurally complex merocytochalasans, were isolated from Aspergillus flavipes. AsperflavipineA (1), which contains two…”
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Two new α-pyrone-containing polyketides isolated from the fungus Aspergillus aureoterreus by Zhou, Beiping, Tong, Qingyi, Zang, Yi, Zhu, Honghui

“…Two undescribed α-pyrone-containing polyketide derivatives designated aurovertins V (1) and W (2), and a known analogue (3), were isolated from the fungus…”
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Force-Dependent Intercalative Bulky DNA Adduct Formation Detected by Single-Molecule Stretching by Liu, Yajun, Pei, Yufeng, Xu, Jingjing, Cheng, Yuanlei, Tong, Qingyi, You, Huijuan

“…Quantitatively analyzing the binding topology and reactivity is essential for understanding the cytotoxic or tumorigenic activities of bulky DNA adducts formed…”
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Distinguishing G‑Quadruplexes Stabilizer and Chaperone for c-MYC Promoter G‑Quadruplexes through Single-Molecule Manipulation by Zhang, Yashuo, Cheng, Yuanlei, Luo, Qun, Wu, Tongbo, Huo, Junfeng, Yin, Meng, Peng, Hui, Xiao, Yang, Tong, Qingyi, You, Huijuan

“…G-quadruplex (G4) selective stabilizing ligands can regulate c-MYC gene expression, but the kinetic basis remains unclear. Determining the effects of ligands…”
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Force-Dependent Intercalative Bulky DNA Adduct Formation Detected by Single-Molecule Stretching by Liu, Yajun, Pei, Yufeng, Xu, Jingjing, Cheng, Yuanlei, Tong, Qingyi, You, Huijuan

“…A picoliter thin-layer chromatography (pTLC) platform was developed for analyzing extremely miniature specimens, such as assay of the contents of a single cell…”
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