Search Results - "Tong, M H"

CircFOXK2 Promotes Growth and Metastasis of Pancreatic Ductal Adenocarcinoma by Complexing with RNA Binding Proteins and Sponging MiR-942 by Wong, Chi Hin, Lou, Ut Kei, Li, Youjia, Chan, Stephen L, Tong, Joanna H M, To, Ka-Fai, Chen, Yangchao

“…The detailed biological functions of circular RNA (circRNA) are largely unexplored. Using circRNA sequencing, we identified 169 differentially expressed…”
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CircRTN4 promotes pancreatic cancer progression through a novel CircRNA-miRNA-lncRNA pathway and stabilizing epithelial-mesenchymal transition protein by Wong, Chi Hin, Lou, Ut Kei, Fung, Frederic Khe-Cheong, Tong, Joanna H M, Zhang, Chang-Hua, To, Ka-Fai, Chan, Stephen Lam, Chen, Yangchao

“…Circular RNAs (circRNAs) play important roles in many biological processes. However, the detailed mechanism underlying the critical roles of circRNAs in cancer…”
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Genome‐wide identification of Epstein‐Barr virus–driven promoter methylation profiles of human genes in gastric cancer cells by Zhao, Junhong, Liang, Qiaoyi, Cheung, Kin‐Fai, Kang, Wei, Lung, Raymond W. M., Tong, Joanna H. M., To, Ka Fai, Sung, Joseph J. Y., Yu, Jun

“…BACKGROUND: Aberrant methylation of tumor‐related genes has been reported in Epstein‐Barr virus (EBV)‐associated gastric cancers. This study sought to profile…”
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FGF18–FGFR2 signaling triggers the activation of c-Jun–YAP1 axis to promote carcinogenesis in a subgroup of gastric cancer patients and indicates translational potential by Zhang, Jinglin, Wong, Chi Chun, Leung, Kam Tong, Wu, Feng, Zhou, Yuhang, Tong, Joanna H. M., Chan, Ronald C. K., Li, Hui, Wang, Yifei, Yan, Huan, Liu, Liping, Wu, William K. K., Chan, Michael W. Y., Cheng, Alfred S. L., Yu, Jun, Wong, Nathalie, Lo, Kwok Wai, To, Ka Fai, Kang, Wei

“…Fibroblast growth factor receptor type 2 (FGFR2) has emerged as a key oncogenic factor that regulates gastric cancer (GC) progression, but the underlying…”
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Stathmin1 plays oncogenic role and is a target of microRNA-223 in gastric cancer by Kang, Wei, Tong, Joanna H M, Chan, Anthony W H, Lung, Raymond W M, Chau, Shuk Ling, Wong, Queenie W L, Wong, Nathalie, Yu, Jun, Cheng, Alfred S L, To, Ka Fai

“…Stathmin1 (STMN1) is a candidate oncoprotein and prognosis marker in several kinds of cancers. This study was aimed to analyze its expression and biological…”
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Targeting of YAP1 by microRNA-15a and microRNA-16-1 exerts tumor suppressor function in gastric adenocarcinoma by Kang, Wei, Tong, Joanna H M, Lung, Raymond W M, Dong, Yujuan, Zhao, Junhong, Liang, Qiaoyi, Zhang, Li, Pan, Yi, Yang, Weiqin, Pang, Jesse C S, Cheng, Alfred S L, Yu, Jun, To, Ka Fai

“…MicroRNAs (miRNAs) have been reported to play an important role in tumorigenesis. In this study, the role of miR-15a and miR-16-1 in gastric adenocarcinoma…”
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Yes-Associated Protein 1 Exhibits Oncogenic Property in Gastric Cancer and Its Nuclear Accumulation Associates with Poor Prognosis by WEI KANG, TONG, Joanna H. M, SUNG, Joseph J. Y, TO, Ka-Fai, CHAN, Anthony W. H, LEE, Tin-Lap, LUNG, Raymond W. M, LEUNG, Patrick P. S, SO, Ken K. Y, KAICHUN WU, DAIMING FAN, JUN YU

“…Yes-associated protein 1 (YAP1) is a multifunctional protein that can interact with different transcription factors to activate gene expression. The role of…”
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Evaluating and Improving Neonatal Gentamicin Pharmacokinetic Models Using Aggregated Routine Clinical Care Data by Tong, Dominic M. H, Hughes, Jasmine H, Keizer, Ron J

“…Model-informed precision dosing (MIPD) can aid dose decision-making for drugs such as gentamicin that have high inter-individual variability, a narrow…”
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Maturation of human embryonic stem cell-derived cardiomyocytes (hESC-CMs) in 3D collagen matrix: Effects of niche cell supplementation and mechanical stimulation by Zhang, W., Kong, C.W., Tong, M.H., Chooi, W.H., Huang, N., Li, R.A., Chan, B.P.

“…[Display omitted] Cardiomyocytes derived from human embryonic stem cells (hESC-CMs) are regarded as a promising source for regenerative medicine, drug testing…”
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Eukaryotic elongation factor-2 kinase expression is an independent prognostic factor in colorectal cancer by Ng, Tung H, Sham, Kathy W Y, Xie, Chuan M, Ng, Simon S M, To, Ka F, Tong, Joanna H M, Liu, Wing Y Z, Zhang, Lin, Chan, Matthew T V, Wu, William K K, Cheng, Christopher H K

“…Prognostication of patients with colorectal cancer (CRC) currently relies on tumor-node-metastasis (TNM) staging but clinical outcomes of patients of the same…”
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TOP2A overexpression in hepatocellular carcinoma correlates with early age onset, shorter patients survival and chemoresistance by Wong, Nathalie, Yeo, Winnie, Wong, Wai‐Lap, Wong, Navy L.‐Y., Chan, Kathy Y.‐Y., Mo, Frankie K.‐F., Koh, Jane, Chan, Stephan Lam, Chan, Anthony T.‐C., Lai, Paul B.‐S., Ching, Arthur K.‐K., Tong, Joanna H.‐M., Ng, Ho‐Keung, Johnson, Philip J., To, Ka‐Fai

“…Genomic gain represents an important mechanism in the activation of proto‐oncogenes. In many instances, induced oncogenes hold clinical implications both as…”
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Isolated Ocular Relapse of Acute Myeloid Leukaemia Post Allogeneic Stem Cell Transplant by Tong, M. H., Kwok, A., Walsh, A., Heydon, P., Koh, E. S., McNamara, N., Bryant, A.

“…We present a rare case of a 39-year-old female with extramedullary relapse of acute myeloid leukaemia (AML) isolated to the left eye 2 months post allogeneic…”
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Detection of ALK rearrangement by immunohistochemistry in lung adenocarcinoma and the identification of a novel EML4-ALK variant by To, Ka-Fai, Tong, Joanna H M, Yeung, King S F, Lung, Raymond W M, Law, Peggy P Y, Chau, Shuk Ling, Kang, Wei, Tong, Carol Y K, Chow, Chit, Chan, Anthony W H, Leung, Linda K S, Mok, Tony S K

“…The echinoderm microtubule-associated protein-like 4 anaplastic lymphoma kinase (EML4-ALK) fusion gene has been identified as a potent oncogenic driver in…”
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TEAD1/4 exerts oncogenic role and is negatively regulated by miR-4269 in gastric tumorigenesis by Zhou, Y, Huang, T, Zhang, J, Wong, C C, Zhang, B, Dong, Y, Wu, F, Tong, J H M, Wu, W K K, Cheng, A S L, Yu, J, Kang, W, To, K F

“…TEA domain (TEAD) transcription factors are key components of the Hippo–YAP1 signaling pathway, but their functional role and regulatory mechanisms remain…”
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miR-375 is involved in Hippo pathway by targeting YAP1/TEAD4-CTGF axis in gastric carcinogenesis by Kang, Wei, Huang, Tingting, Zhou, Yuhang, Zhang, Jinglin, Lung, Raymond W. M., Tong, Joanna H. M., Chan, Anthony W. H., Zhang, Bin, Wong, Chi Chun, Wu, Feng, Dong, Yujuan, Wang, Shiyan, Yang, Weiqin, Pan, Yi, Chak, Wing Po, Cheung, Alvin H. K., Pang, Jesse C. S., Yu, Jun, Cheng, Alfred S. L., To, Ka Fai

“…miR-375 is a tumor-suppressive microRNA (miRNA) in gastric cancer (GC). However, its molecular mechanism remains unclear. The aim of this study is to…”
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let-7b/g silencing activates AKT signaling to promote gastric carcinogenesis by Kang, Wei, Tong, Joanna H M, Lung, Raymond W M, Dong, Yujuan, Yang, Weiqin, Pan, Yi, Lau, Kin Mang, Yu, Jun, Cheng, Alfred Sl, To, Ka Fai

“…Aberrant AKT activation contributes to gastric cancer cell survival and chemotherapy resistance, however its regulation is poorly understood. microRNAs have…”
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Expression of stemness markers (CD133 and EpCAM) in prognostication of hepatocellular carcinoma by Chan, Anthony W H, Tong, Joanna H M, Chan, Stephen L, Lai, Paul B S, To, Ka-Fai

“…Aims The expression of stemness markers in hepatocellular carcinoma (HCC) is suggested to be associated with poor clinical outcome after surgical resection…”
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EBV‐encoded miRNAs target ATM‐mediated response in nasopharyngeal carcinoma by Lung, Raymond W‐M, Hau, Pok‐Man, Yu, Ken H‐O, Yip, Kevin Y, Tong, Joanna H‐M, Chak, Wing‐Po, Chan, Anthony W‐H, Lam, Ka‐Hei, Lo, Angela Kwok‐Fung, Tin, Edith K‐Y, Chau, Shuk‐Ling, Pang, Jesse C‐S, Kwan, Johnny S‐H, Busson, Pierre, Young, Lawrence S, Yap, Lee‐Fah, Tsao, Sai‐Wah, To, Ka‐Fai, Lo, Kwok‐Wai

“…Nasopharyngeal carcinoma (NPC) is a highly invasive epithelial malignancy that is prevalent in southern China and Southeast Asia. It is consistently associated…”
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Tissue and cellular tropism of the coronavirus associated with severe acute respiratory syndrome: an in-situ hybridization study of fatal cases by To, KF, Tong, Joanna HM, Chan, Paul KS, Au, Florence WL, Chim, Stephen SC, Allen Chan, KC, Cheung, Jo LK, Liu, Esther YM, Tse, Gary MK, Lo, Anthony WI, Dennis Lo, YM, Ng, HK

“…Severe acute respiratory syndrome (SARS) is a new human infectious disease with significant morbidity and mortality. The disease has been shown to be…”
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Clinical decision support for chemotherapy‐induced neutropenia using a hybrid pharmacodynamic/machine learning model by Hughes, Jasmine H., Tong, Dominic M. H., Burns, Vanessa, Daly, Bobby, Razavi, Pedram, Boelens, Jaap J., Goswami, Srijib, Keizer, Ron J.

“…Consensus guidelines recommend use of granulocyte colony stimulating factor in patients deemed at risk of chemotherapy‐induced neutropenia, however, these risk…”
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