Search Results - "Tong, Huaxiang"

Regulation of Fatty Acid Synthesis by Farnesyl Pyrophosphate by Murthy, Shubha, Tong, Huaxiang, Hohl, Raymond J.

“…Fatty acid biosynthesis is transcriptionally regulated by liver X receptor (LXR) and its gene target, sterol regulatory element binding protein-1c (SREBP-1c)…”
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Quantitative Determination of Geranyl Diphosphate Levels in Cultured Human Cells by Holstein, Sarah A, Tong, Huaxiang, Kuder, Craig H, Hohl, Raymond J

“…Geranyl diphosphate (GPP), a 10-carbon isoprenoid, is a key intermediate in the isoprenoid biosynthetic pathway. This pathway, in addition to leading to sterol…”
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Olefin Isomers of a Triazole Bisphosphonate Synergistically Inhibit Geranylgeranyl Diphosphate Synthase by Allen, Cheryl, Kortagere, Sandhya, Tong, Huaxiang, Matthiesen, Robert A, Metzger, Joseph I, Wiemer, David F, Holstein, Sarah A

“…The isoprenoid donor for protein geranylgeranylation reactions, geranylgeranyl diphosphate (GGDP), is the product of the enzyme GGDP synthase (GGDPS) that…”
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Effects of selective inhibitors of the isoprenoid biosynthetic pathway on androgen‐dependent and independent prostate cancer cells (842.6) by Reilly, Jacqueline, Zhou, Xiang, Tong, Huaxiang, Wiemer, David, Hohl, Raymond

“…The isoprenoid biosynthetic pathway (IBP) provides substrates, such as geranylgeranyl diphosphate (GGDP), which are used to post‐translationally modify…”
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Synergistic Inhibition of Geranylgeranyl Diphosphate Synthase By a Mixture of Olefin Stereoisomers by Allen, Cheryl, Metzger, Joseph I., Wills, Veronica S., Tong, Huaxiang, Kortagere, Sandhya, Wiemer, David F., Holstein, Sarah A.

“…The production of monoclonal protein (MP) by malignant plasma cells is a hallmark of multiple myeloma (MM). We have previously demonstrated that targeting the…”
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Geranylgeranyl diphosphate depletion inhibits breast cancer cell migration by Dudakovic, Amel, Tong, Huaxiang, Hohl, Raymond J.

“…Summary The objective of this study was to determine whether geranylgeranyl diphosphate synthase inhibition, and therefore geranylgeranyl diphosphate…”
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Geranyl and neryl triazole bisphosphonates as inhibitors of geranylgeranyl diphosphate synthase by Zhou, Xiang, Ferree, Sarah D., Wills, Veronica S., Born, Ella J., Tong, Huaxiang, Wiemer, David F., Holstein, Sarah A.

“…When inhibitors of enzymes that utilize isoprenoid pyrophosphates are based on the natural substrates, a significant challenge can be to achieve selective…”
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Mechanisms for autophagy modulation by isoprenoid biosynthetic pathway inhibitors in multiple myeloma cells by Dykstra, Kaitlyn M, Allen, Cheryl, Born, Ella J, Tong, Huaxiang, Holstein, Sarah A

“…Multiple myeloma (MM) is characterized by the production of monoclonal protein (MP). We have shown previously that disruption of the isoprenoid biosynthetic…”
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Targeting geranylgeranylation reduces adrenal gland tumor burden in a murine model of prostate cancer metastasis by Reilly, Jacqueline E., Neighbors, Jeffrey D., Tong, Huaxiang, Henry, Michael D., Hohl, Raymond J.

“…The isoprenoid biosynthetic pathway (IBP) is critical for providing substrates for the post-translational modification of proteins key in regulating malignant…”
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Quantitative determination of isopentenyl diphosphate in cultured mammalian cells by Tong, Huaxiang, Kuder, Craig H., Wasko, Brian M., Hohl, Raymond J.

“…Isopentenyl diphosphate (IPP), an intermediate of the isoprenoid biosynthetic pathway (IBP), has several important biological functions, yet a method to…”
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Dissecting The Effects Of Isoprenoid Pathway Inhibition On Hemostasis and Thrombosis: Differential Effects Of Atorvastatin and Digeranyl Bisphosphonate In Hypercholesterolemic Mice by Bhasin, Neha, Stevens, Jeff, Niki, Masaru, Tong, Huaxiang, Kuder, Craig, Hohl, Raymond J., Lentz, Steven R

“…Statins inhibit HMG-CoA reductase, leading to decreased production of cholesterol and isoprenoid metabolites. There is growing evidence that statins have…”
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Digeranyl bisphosphonate inhibits geranylgeranyl pyrophosphate synthase by Wiemer, Andrew J., Tong, Huaxiang, Swanson, Kelly M., Hohl, Raymond J.

“…A primary cellular target of the clinical nitrogenous bisphosphonates is the isoprenoid biosynthetic pathway. Specifically these drugs inhibit the enzyme…”
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In vitro studies in a myelogenous leukemia cell line suggest an organized binding of geranylgeranyl diphosphate synthase inhibitors by Reilly, Jacqueline E., Zhou, Xiang, Tong, Huaxiang, Kuder, Craig H., Wiemer, David F., Hohl, Raymond J.

“…A small set of isoprenoid bisphosphonates ethers has been tested in the K562 chronic myelogenous leukemia cell line to determine their impact on isoprenoid…”
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Development of selective inhibitors of the isoprenoid biosynthetic pathway and their effects on human‐derived chronic myelogenous leukemia cells by Reilly, Jacqueline E, Zhou, Xiang, Tong, Huaxiang, Wiemer, David, Hohl, Raymond J

“…Abstract only Proteins dependent on post‐translational geranylgeranylation by the isoprenoid biosynthetic pathway (IBP) are key regulators of malignant cell…”
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Synthesis and Structure-Function Relationship Of Novel Triazole Phosphonates As Inhibitors Of Rab Geranylgeranyl Transferase by Ferree, Sarah D., Zhou, Xiang, Wills, Veronica S., Born, Ella J., Tong, Huaxiang, Wiemer, David F., Holstein, Sarah A

“…Multiple myeloma is characterized by the proliferation of malignant plasma cells which secrete large quantities of monoclonal protein (MP). As yet, no…”
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Quantitative determination of farnesyl and geranylgeranyl diphosphate levels in mammalian tissue by Tong, Huaxiang, Wiemer, Andrew J., Neighbors, Jeffrey D., Hohl, Raymond J.

“…Farnesyl diphosphate (FPP) and geranylgeranyl diphosphate (GGPP) are branch point intermediates of isoprenoid biosynthesis. Inhibitors of isoprenoid…”
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Abstract 170: Differential Effects of Atorvastatin and Digeranyl Bisphosphonate on Hemostasis and Thrombosis in Hypercholesterolemic Mice by Bhasin, Neha, Stevens, Jeff W, Niki, Masaru, Tong, Huaxiang, Kuder, Craig H, Hohl, Raymond J, Lentz, Steven R

“…Abstract only…”
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Pleiotropic Effects of a Schweinfurthin on Isoprenoid Homeostasis by Holstein, Sarah A., Kuder, Craig H., Tong, Huaxiang, Hohl, Raymond J.

“…The schweinfurthins, a family of natural products derived from the isoprenoid biosynthetic pathway (IBP), have marked growth inhibitory activity. However, the…”
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2-Amino-3-ketobutyrate-CoA ligase from beef liver mitochondria. Purification and partial sequence by Tong, H, Davis, L

“…2-Amino-3-ketobutyrate-CoA ligase (EC 2.3.1.29), or aminoacetone synthetase, has been purified by a nine-step procedure from 1.0 kg of beef liver to yield 8.8…”
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Differential activities of thalidomide and isoprenoid biosynthetic pathway inhibitors in multiple myeloma cells by Holstein, Sarah A, Tong, Huaxiang, Hohl, Raymond J

“…Abstract Thalidomide has emerged as an effective agent for treating multiple myeloma, however the precise mechanism of action remains unknown. Agents known to…”
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