Search Results - "Tong, Benjamin Chun‐Kit"

A small molecule transcription factor EB activator ameliorates beta‐amyloid precursor protein and Tau pathology in Alzheimer's disease models by Song, Ju‐Xian, Malampati, Sandeep, Zeng, Yu, Durairajan, Siva Sundara Kumar, Yang, Chuan‐Bin, Tong, Benjamin Chun‐Kit, Iyaswamy, Ashok, Shang, Wen‐Bin, Sreenivasmurthy, Sravan Gopalkrishnashetty, Zhu, Zhou, Cheung, King‐Ho, Lu, Jia‐Hong, Tang, Chunzhi, Xu, Nenggui, Li, Min

“…Accumulating studies have suggested that targeting transcription factor EB (TFEB), an essential regulator of autophagy‐lysosomal pathway (ALP), is promising…”
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A Curcumin Derivative Activates TFEB and Protects Against Parkinsonian Neurotoxicity in Vitro by Wang, Ziying, Yang, Chuanbin, Liu, Jia, Chun-Kit Tong, Benjamin, Zhu, Zhou, Malampati, Sandeep, Gopalkrishnashetty Sreenivasmurthy, Sravan, Cheung, King-Ho, Iyaswamy, Ashok, Su, Chengfu, Lu, Jiahong, Song, Juxian, Li, Min

“…bstract TFEB (transcription factor EB), which is a master regulator of autophagy and lysosome biogenesis, is considered to be a new therapeutic target for…”
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Targeting calcium signaling by inositol trisphosphate receptors: A novel mechanism for the anti-asthmatic effects of Houttuynia cordata by Huang, Alexis Shiying, Tong, Benjamin Chun-Kit, Hung, Harry Chun-Hin, Wu, Aston Jiaxi, Ho, Olivia Ka-Yi, Kong, Anna Hau-Yee, Leung, Maggie Ming-Ki, Bai, Jingxuan, Fu, Xiuqiong, Yu, Zhiling, Li, Min, Leung, Ting Fan, Mak, Judith Choi-Wo, Leung, George Pak-Heng, Cheung, King-Ho

“…Asthma is a chronic inflammatory disease characterized by airway hypersensitivity and remodeling. The current treatments provide only short-term benefits and…”
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Targeting Aggrephagy for the Treatment of Alzheimer's Disease by Malampati, Sandeep, Song, Ju-Xian, Chun-Kit Tong, Benjamin, Nalluri, Anusha, Yang, Chuan-Bin, Wang, Ziying, Gopalkrishnashetty Sreenivasmurthy, Sravan, Zhu, Zhou, Liu, Jia, Su, Chengfu, Krishnamoorthi, Senthilkumar, Iyaswamy, Ashok, Cheung, King-Ho, Lu, Jia-Hong, Li, And Min

“…Alzheimer's disease (AD) is one of the most common neurodegenerative diseases in older individuals with specific neuropsychiatric symptoms. It is a…”
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Balancing mTOR Signaling and Autophagy in the Treatment of Parkinson's Disease by Zhu, Zhou, Yang, Chuanbin, Iyaswamy, Ashok, Krishnamoorthi, Senthilkumar, Sreenivasmurthy, Sravan Gopalkrishnashetty, Liu, Jia, Wang, Ziying, Tong, Benjamin Chun-Kit, Song, Juxian, Lu, Jiahong, Cheung, King-Ho, Li, Min

“…The mammalian target of rapamycin (mTOR) signaling pathway plays a critical role in regulating cell growth, proliferation, and life span. mTOR signaling is a…”
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Theranostic F-SLOH mitigates Alzheimer's disease pathology involving TFEB and ameliorates cognitive functions in Alzheimer's disease models by Iyaswamy, Ashok, Wang, Xueli, Krishnamoorthi, Senthilkumar, Kaliamoorthy, Venkatapathy, Sreenivasmurthy, Sravan G., Kumar Durairajan, Siva Sundara, Song, Ju-Xian, Tong, Benjamin Chun-kit, Zhu, Zhou, Su, Cheng-Fu, Liu, Jia, Cheung, King-Ho, Lu, Jia-Hong, Tan, Jie-Qiong, Li, Hung Wing, Wong, Man Shing, Li, Min

“…Accumulation of amyloid-β (Aβ) oligomers and phosphorylated Tau aggregates are crucial pathological events or factors that cause progressive neuronal loss, and…”
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Tetrandrine ameliorates cognitive deficits and mitigates tau aggregation in cell and animal models of tauopathies by Tong, Benjamin Chun-Kit, Huang, Alexis Shiying, Wu, Aston Jiaxi, Iyaswamy, Ashok, Ho, Olivia Ka-Yi, Kong, Anna Hau-Yee, Sreenivasmurthy, Sravan Gopalkrishnashetty, Zhu, Zhou, Su, Chengfu, Liu, Jia, Song, Juxian, Li, Min, Cheung, King-Ho

“…Abstract Background Tauopathies are neurodegenerative diseases that are associated with the pathological accumulation of tau-containing tangles in the brain…”
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A stress response p38 MAP kinase inhibitor SB202190 promoted TFEB/TFE3-dependent autophagy and lysosomal biogenesis independent of p38 by Yang, Chuanbin, Zhu, Zhou, Tong, Benjamin Chun-Kit, Iyaswamy, Ashok, Xie, Wen-Jian, Zhu, Yu, Sreenivasmurthy, Sravan Gopalkrishnashetty, Senthilkumar, Krishnamoorthi, Cheung, King-Ho, Song, Ju-Xian, Zhang, Hong-Jie, Li, Min

“…TFEB (transcription factor EB) and TFE3 (transcription factor E3) are “master regulators” of autophagy and lysosomal biogenesis. The stress response p38…”
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Characterization of Two-Pore Channel 2 by Nuclear Membrane Electrophysiology by Lee, Claire Shuk-Kwan, Tong, Benjamin Chun-Kit, Cheng, Cecily Wing-Hei, Hung, Harry Chun-Hin, Cheung, King-Ho

“…Lysosomal calcium (Ca 2+ ) release mediated by NAADP triggers signalling cascades that regulate many cellular processes. The identification of two-pore channel…”
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Calcium signaling in Alzheimer's disease & therapies by Tong, Benjamin Chun-Kit, Wu, Aston Jiaxi, Li, Min, Cheung, King-Ho

“…Alzheimer's disease (AD) is the most common type of dementia and is characterized by the accumulation of amyloid (Aβ) plaques and neurofibrillary tangles in…”
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Lysosomal TPCN (two pore segment channel) inhibition ameliorates beta-amyloid pathology and mitigates memory impairment in Alzheimer disease by Tong, Benjamin Chun-Kit, Wu, Aston Jiaxi, Huang, Alexis Shiying, Dong, Rui, Malampati, Sandeep, Iyaswamy, Ashok, Krishnamoorthi, Senthilkumar, Sreenivasmurthy, Sravan Gopalkrishnashetty, Zhu, Zhou, Su, Chengfu, Liu, Jia, Song, Juxian, Lu, Jia-Hong, Tan, Jieqiong, Pan, Weidong, Li, Min, Cheung, King-Ho

“…Impairment of the macroautophagy/autophagy-lysosomal pathway (ALP) can lead to amyloid plaque accumulation in Alzheimer disease (AD); however, the underlying…”
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Protopine promotes the proteasomal degradation of pathological tau in Alzheimer's disease models via HDAC6 inhibition by Sreenivasmurthy, Sravan Gopalkrishnashetty, Iyaswamy, Ashok, Krishnamoorthi, Senthilkumar, Senapati, Sanjib, Malampati, Sandeep, Zhu, Zhou, Su, Cheng-Fu, Liu, Jia, Guan, Xin-Jie, Tong, Benjamin Chun-Kit, Cheung, King-Ho, Tan, Jie-Qiong, Lu, Jia-Hong, Durairajan, Siva Sundara Kumar, Song, Ju-Xian, Li, Min

“…•The natural alkaloid protopine is brain-permeable, which improves memory functions in 3xTg-AD and P301S tau transgenic models of AD.•Protopine specifically…”
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Corynoxine B derivative CB6 prevents Parkinsonian toxicity in mice by inducing PIK3C3 complex-dependent autophagy by Zhu, Zhou, Liu, Liang-feng, Su, Cheng-fu, Liu, Jia, Tong, Benjamin Chun-Kit, Iyaswamy, Ashok, Krishnamoorthi, Senthilkumar, Sreenivasmurthy, Sravan Gopalkrishnashetty, Guan, Xin-jie, Kan, Yu-xuan, Xie, Wen-jian, Zhao, Chen-liang, Cheung, King-ho, Lu, Jia-hong, Tan, Jie-qiong, Zhang, Hong-jie, Song, Ju-xian, Li, Min

“…Increasing evidence shows that autophagy impairment is involved in the pathogenesis and progression of neurodegenerative diseases including Parkinson’s disease…”
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Corynoxine promotes TFEB/TFE3-mediated autophagy and alleviates Aβ pathology in Alzheimer’s disease models by Guan, Xin-jie, Deng, Zhi-qiang, Liu, Jia, Su, Cheng-fu, Tong, Benjamin Chun-Kit, Zhu, Zhou, Sreenivasmurthy, Sravan Gopalkrishnashetty, Kan, Yu-xuan, Lu, Ke-jia, Chu, Carol Pui-Kei, Pi, Rong-biao, Cheung, King-ho, Iyaswamy, Ashok, Song, Ju-xian, Li, Min

“…Autophagy impairment is a key factor in Alzheimer’s disease (AD) pathogenesis. TFEB (transcription factor EB) and TFE3 (transcription factor binding to IGHM…”
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TFEB, a master regulator of autophagy and biogenesis, unexpectedly promotes apoptosis in response to the cyclopentenone prostaglandin 15d-PGJ2 by Yang, Chuan-bin, Liu, Jia, Tong, Benjamin Chun-Kit, Wang, Zi-ying, Zhu, Zhou, Su, Cheng-fu, Sreenivasmurthy, Sravan Gopalkrishnashetty, Wu, Jia-xi, Iyaswamy, Ashok, Krishnamoorthi, Senthilkumar, Huang, Shi-ying, Cheung, King-ho, Song, Ju-xian, Tan, Jie-qiong, Lu, Jia-hong, Li, Min

“…Transcriptional factor EB (TFEB), a master regulator of autophagy and lysosomal biogenesis, is generally regarded as a pro-survival factor. Here, we identify…”
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Correction to: InsP3R-SEC5 interaction on phagosomes modulates innate immunity to Candida albicans by promoting cytosolic Ca 2+ elevation and TBK1 activity by Yang, Long, Gu, Wenwen, Cheung, King-Ho, Yan, Lan, Tong, Benjamin Chun-Kit, Jiang, Yuanying, Yang, Jun

“…An amendment to this paper has been published and can be accessed via the original article…”
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NeuroDefend, a novel Chinese medicine, attenuates amyloid-β and tau pathology in experimental Alzheimer's disease models by Iyaswamy, Ashok, Krishnamoorthi, Senthil Kumar, Song, Ju-Xian, Yang, Chuan-Bin, Kaliyamoorthy, Venkatapathy, Zhang, Huan, Sreenivasmurthy, Sravan G., Malampati, Sandeep, Wang, Zi-Ying, Zhu, Zhou, Tong, Benjamin Chun-Kit, Cheung, King-Ho, Lu, Jia-Hong, Durairajan, Siva Sundara Kumar, Li, Min

“…Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder. Amyloid-β (Aβ) and hyper-phosphorylated tau accumulation are accountable…”
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InsP3R-SEC5 interaction on phagosomes modulates innate immunity to Candida albicans by promoting cytosolic Ca2+ elevation and TBK1 activity by Yang, Long, Gu, Wenwen, Cheung, King-Ho, Yan, Lan, Tong, Benjamin Chun-Kit, Jiang, Yuanying, Yang, Jun

“…Abstract Background Candida albicans ( C. albicans ) invasion triggers antifungal innate immunity, and the elevation of cytoplasmic Ca 2+ levels via the…”
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Familial Alzheimer's disease-associated presenilin 1 mutants promote γ-secretase cleavage of STIM1 to impair store-operated Ca2+ entry by Tong, Benjamin Chun-Kit, Lee, Claire Shuk-Kwan, Cheng, Wing-Hei, Lai, Kwok-On, Foskett, J Kevin, Cheung, King-Ho

“…Some forms of familial Alzheimer's disease (FAD) are caused by mutations in presenilins (PSs), catalytic components of a γ-secretase complex that cleaves…”
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Houttuynia Cordata Essential Oil Mitigates Airway Remodeling in Asthma by Rectifying IP3R‐mediated Ca2+ Disruption by Huang, Alexis Shiying, Hung, Chun‐Hin, Tong, Benjamin Chun‐Kit, Wu, Aston Jiaxi, Bai, Jingxuan, Fu, Xiuqiong, Yu, Zhiling, Cheung, King‐Ho

“…Asthma is a common chronic airway inflammatory disease that leads to airway narrowing during the attacks. Beta‐adrenergic agonists provide temporary relaxation…”
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